Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study
BackgroundVagus nerve stimulation (VNS) has been demonstrated to be safe and effective for patients with refractory epilepsy, but there are few reports on the use of VNS for postencephalitic epilepsy (PEE). This retrospective study aimed to evaluate the efficacy of VNS for refractory PEE.MethodsWe r...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.685685/full |
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| author | Yulin Sun Yulin Sun Jian Chen Jian Chen Tie Fang Lin Wan Lin Wan Xiuyu Shi Xiuyu Shi Xiuyu Shi Jing Wang Jing Wang Zhichao Li Zhichao Li Jiaxin Wang Jiaxin Wang Zhiqiang Cui Xin Xu Zhipei Ling Liping Zou Liping Zou Guang Yang Guang Yang Guang Yang |
| author_facet | Yulin Sun Yulin Sun Jian Chen Jian Chen Tie Fang Lin Wan Lin Wan Xiuyu Shi Xiuyu Shi Xiuyu Shi Jing Wang Jing Wang Zhichao Li Zhichao Li Jiaxin Wang Jiaxin Wang Zhiqiang Cui Xin Xu Zhipei Ling Liping Zou Liping Zou Guang Yang Guang Yang Guang Yang |
| author_sort | Yulin Sun |
| collection | DOAJ |
| description | BackgroundVagus nerve stimulation (VNS) has been demonstrated to be safe and effective for patients with refractory epilepsy, but there are few reports on the use of VNS for postencephalitic epilepsy (PEE). This retrospective study aimed to evaluate the efficacy of VNS for refractory PEE.MethodsWe retrospectively studied 20 patients with refractory PEE who underwent VNS between August 2017 and October 2019 in Chinese PLA General Hospital and Beijing Children’s Hospital. VNS efficacy was evaluated based on seizure reduction, effective rate (percentage of cases with seizure reduction ≥ 50%), McHugh classification, modified Early Childhood Epilepsy Severity Scale (E-Chess) score, and Grand Total EEG (GTE) score. The follow-up time points were 3, 6, and 12 months after VNS. Pre- and postoperative data were compared and analyzed.ResultsThe median [interquartile range (IQR)] seizure reduction rates at 3, 6, and 12 months after VNS were 23.72% (0, 55%), 46.61% (0, 79.04%), and 67.99% (0, 93.78%), respectively. The effective rates were 30% at 3 months, 45% at 6 months, and 70% at 12 months. E-chess scores before the operation and at 3, 6, and 12 months after the operation were 10 (10, 10.75), 9 (9, 10), 9 (9, 9.75), and 9 (8.25, 9) (P < 0.05), respectively. GTE scores before surgery and at 12 months after the operation were 11 (9, 13) and 9 (7, 11) (P < 0.05), respectively. The mean intensity of VNS current was 1.76 ± 0.39 (range: 1.0–2.5) mA. No intraoperative complications or severe post-operative adverse effects were reported.ConclusionsOur study shows that VNS can reduce the frequency and severity of seizure in patients with refractory PEE. VNS has a good application prospect in patients with refractory PEE. |
| first_indexed | 2024-12-16T17:57:03Z |
| format | Article |
| id | doaj.art-43854d9abb9d45e4ae4e564f59545c50 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-16T17:57:03Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-43854d9abb9d45e4ae4e564f59545c502022-12-21T22:22:08ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-08-011510.3389/fnins.2021.685685685685Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective StudyYulin Sun0Yulin Sun1Jian Chen2Jian Chen3Tie Fang4Lin Wan5Lin Wan6Xiuyu Shi7Xiuyu Shi8Xiuyu Shi9Jing Wang10Jing Wang11Zhichao Li12Zhichao Li13Jiaxin Wang14Jiaxin Wang15Zhiqiang Cui16Xin Xu17Zhipei Ling18Liping Zou19Liping Zou20Guang Yang21Guang Yang22Guang Yang23Department of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Functional Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurosurgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurosurgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurosurgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatrics, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaBackgroundVagus nerve stimulation (VNS) has been demonstrated to be safe and effective for patients with refractory epilepsy, but there are few reports on the use of VNS for postencephalitic epilepsy (PEE). This retrospective study aimed to evaluate the efficacy of VNS for refractory PEE.MethodsWe retrospectively studied 20 patients with refractory PEE who underwent VNS between August 2017 and October 2019 in Chinese PLA General Hospital and Beijing Children’s Hospital. VNS efficacy was evaluated based on seizure reduction, effective rate (percentage of cases with seizure reduction ≥ 50%), McHugh classification, modified Early Childhood Epilepsy Severity Scale (E-Chess) score, and Grand Total EEG (GTE) score. The follow-up time points were 3, 6, and 12 months after VNS. Pre- and postoperative data were compared and analyzed.ResultsThe median [interquartile range (IQR)] seizure reduction rates at 3, 6, and 12 months after VNS were 23.72% (0, 55%), 46.61% (0, 79.04%), and 67.99% (0, 93.78%), respectively. The effective rates were 30% at 3 months, 45% at 6 months, and 70% at 12 months. E-chess scores before the operation and at 3, 6, and 12 months after the operation were 10 (10, 10.75), 9 (9, 10), 9 (9, 9.75), and 9 (8.25, 9) (P < 0.05), respectively. GTE scores before surgery and at 12 months after the operation were 11 (9, 13) and 9 (7, 11) (P < 0.05), respectively. The mean intensity of VNS current was 1.76 ± 0.39 (range: 1.0–2.5) mA. No intraoperative complications or severe post-operative adverse effects were reported.ConclusionsOur study shows that VNS can reduce the frequency and severity of seizure in patients with refractory PEE. VNS has a good application prospect in patients with refractory PEE.https://www.frontiersin.org/articles/10.3389/fnins.2021.685685/fullvagus nerve stimulationpostencephalitic epilepsyrefractory epilepsyencephalitischildren |
| spellingShingle | Yulin Sun Yulin Sun Jian Chen Jian Chen Tie Fang Lin Wan Lin Wan Xiuyu Shi Xiuyu Shi Xiuyu Shi Jing Wang Jing Wang Zhichao Li Zhichao Li Jiaxin Wang Jiaxin Wang Zhiqiang Cui Xin Xu Zhipei Ling Liping Zou Liping Zou Guang Yang Guang Yang Guang Yang Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study Frontiers in Neuroscience vagus nerve stimulation postencephalitic epilepsy refractory epilepsy encephalitis children |
| title | Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study |
| title_full | Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study |
| title_fullStr | Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study |
| title_full_unstemmed | Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study |
| title_short | Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study |
| title_sort | vagus nerve stimulation therapy for the treatment of seizures in refractory postencephalitic epilepsy a retrospective study |
| topic | vagus nerve stimulation postencephalitic epilepsy refractory epilepsy encephalitis children |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.685685/full |
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