Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation
Purpose: Previous studies showed that genetic variants of the angiotensinogen ( AGT ) gene conferred higher risk for acquired atrial fibrillation (AF). The present study investigated whether AGT variants correlate with the clinical outcome in patients with acquired AF after catheter ablation (CA). M...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320315594315 |
| _version_ | 1797288960033030144 |
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| author | Qunshan Wang Xiaofeng Hu Shuyuan Li Xiaofeng Wang Jun Wang Rui Zhang Jian Sun Pengpai Zhang Xiangfei Feng Yi-Gang Li |
| author_facet | Qunshan Wang Xiaofeng Hu Shuyuan Li Xiaofeng Wang Jun Wang Rui Zhang Jian Sun Pengpai Zhang Xiangfei Feng Yi-Gang Li |
| author_sort | Qunshan Wang |
| collection | DOAJ |
| description | Purpose: Previous studies showed that genetic variants of the angiotensinogen ( AGT ) gene conferred higher risk for acquired atrial fibrillation (AF). The present study investigated whether AGT variants correlate with the clinical outcome in patients with acquired AF after catheter ablation (CA). Methods: A total of 150 acquired symptomatic drug-refractory AF patients (mean age 63.7±11.0 years, 24.6% non-paroxysmal AF) with acquired AF underwent a single CA procedure in our department and were included in this retrospective analysis. Eight tagging single nucleotide polymorphisms (tSNPs) in the AGT gene were genotyped. Standard electrocardiographs (ECGs) and 24-hour Holter recordings were performed during a median follow-up period of 57.5 months to detect AF recurrence. Results: Sixty-one patients (40.7%) suffered AF recurrences after a single CA procedure during follow up. Of the eight tSNPs, the frequency of the M allele of M235T was significantly higher in the recurrence group (28%) compared to the non-recurrence group (18%) ( p =0.042). The recurrence rates of patients with the TT, MT, and MM genotypes were 34.4%, 50%, and 55.6%, respectively ( p trend =0.049). After adjusting for age, sex, body mass index, hypertension, left atrial volume index (LAVI) and other covariates, M235T increased the risk of AF recurrence in additive and dominant models with odds ratios of 2.023 (95% confidence interval (CI): 1.034–3.926, p =0.033) and 2.601 (95% CI: 1.102–6.056, p =0.025), respectively. However, in multiple correction analyses, the p values of multiple comparisons were not statistically significant ( p correct >0.05). Conclusions: The M allele of M235T might be associated with an increased risk of AF recurrence after CA. Genotyping may thus be helpful on identifying patients with higher risks of AF recurrence after CA and developing optimal follow-up strategies. These strategies may differ and should be individualized according to patients’ genotype. Future studies are warranted to validate the potential effect of AGT M235T on AF recurrence post CA. |
| first_indexed | 2024-03-07T18:57:14Z |
| format | Article |
| id | doaj.art-4385ed580ed44aedbb5c046f03b2644c |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:57:14Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-4385ed580ed44aedbb5c046f03b2644c2024-03-02T00:08:16ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320315594315Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillationQunshan Wang0Xiaofeng Hu1Shuyuan Li2Xiaofeng Wang3Jun Wang4Rui Zhang5Jian Sun6Pengpai Zhang7Xiangfei Feng8Yi-Gang Li9Department of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaDepartment of Cardiology, Zhejiang Hospital, ChinaSchool of Life Sciences and Institutes of Biomedical Sciences, Fudan University, ChinaSchool of Life Sciences and Institutes of Biomedical Sciences, Fudan University, ChinaDepartment of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaDepartment of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaDepartment of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaDepartment of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaDepartment of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaDepartment of Cardiology, Shanghai Jiaotong University School of Medicine, ChinaPurpose: Previous studies showed that genetic variants of the angiotensinogen ( AGT ) gene conferred higher risk for acquired atrial fibrillation (AF). The present study investigated whether AGT variants correlate with the clinical outcome in patients with acquired AF after catheter ablation (CA). Methods: A total of 150 acquired symptomatic drug-refractory AF patients (mean age 63.7±11.0 years, 24.6% non-paroxysmal AF) with acquired AF underwent a single CA procedure in our department and were included in this retrospective analysis. Eight tagging single nucleotide polymorphisms (tSNPs) in the AGT gene were genotyped. Standard electrocardiographs (ECGs) and 24-hour Holter recordings were performed during a median follow-up period of 57.5 months to detect AF recurrence. Results: Sixty-one patients (40.7%) suffered AF recurrences after a single CA procedure during follow up. Of the eight tSNPs, the frequency of the M allele of M235T was significantly higher in the recurrence group (28%) compared to the non-recurrence group (18%) ( p =0.042). The recurrence rates of patients with the TT, MT, and MM genotypes were 34.4%, 50%, and 55.6%, respectively ( p trend =0.049). After adjusting for age, sex, body mass index, hypertension, left atrial volume index (LAVI) and other covariates, M235T increased the risk of AF recurrence in additive and dominant models with odds ratios of 2.023 (95% confidence interval (CI): 1.034–3.926, p =0.033) and 2.601 (95% CI: 1.102–6.056, p =0.025), respectively. However, in multiple correction analyses, the p values of multiple comparisons were not statistically significant ( p correct >0.05). Conclusions: The M allele of M235T might be associated with an increased risk of AF recurrence after CA. Genotyping may thus be helpful on identifying patients with higher risks of AF recurrence after CA and developing optimal follow-up strategies. These strategies may differ and should be individualized according to patients’ genotype. Future studies are warranted to validate the potential effect of AGT M235T on AF recurrence post CA.https://doi.org/10.1177/1470320315594315 |
| spellingShingle | Qunshan Wang Xiaofeng Hu Shuyuan Li Xiaofeng Wang Jun Wang Rui Zhang Jian Sun Pengpai Zhang Xiangfei Feng Yi-Gang Li Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation Journal of the Renin-Angiotensin-Aldosterone System |
| title | Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation |
| title_full | Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation |
| title_fullStr | Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation |
| title_full_unstemmed | Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation |
| title_short | Association of the M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation |
| title_sort | association of the m235t polymorphism with recurrence after catheter ablation of acquired atrial fibrillation |
| url | https://doi.org/10.1177/1470320315594315 |
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