Cell Interplay in Osteoarthritis
Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs to be urgently solved. OA affects the cartilage and entire joint tissues, including the subchondral bone, synovium, and infrapatellar fat pads. The physiological and pathological changes in these tissues affe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.720477/full |
| _version_ | 1828916945603264512 |
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| author | Zihao Li Ziyu Huang Lunhao Bai |
| author_facet | Zihao Li Ziyu Huang Lunhao Bai |
| author_sort | Zihao Li |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs to be urgently solved. OA affects the cartilage and entire joint tissues, including the subchondral bone, synovium, and infrapatellar fat pads. The physiological and pathological changes in these tissues affect the occurrence and development of OA. Understanding complex crosstalk among different joint tissues and their roles in OA initiation and progression is critical in elucidating the pathogenic mechanism of OA. In this review, we begin with an overview of the role of chondrocytes, synovial cells (synovial fibroblasts and macrophages), mast cells, osteoblasts, osteoclasts, various stem cells, and engineered cells (induced pluripotent stem cells) in OA pathogenesis. Then, we discuss the various mechanisms by which these cells communicate, including paracrine signaling, local microenvironment, co-culture, extracellular vesicles (exosomes), and cell tissue engineering. We particularly focus on the therapeutic potential and clinical applications of stem cell-derived extracellular vesicles, which serve as modulators of cell-to-cell communication, in the field of regenerative medicine, such as cartilage repair. Finally, the challenges and limitations related to exosome-based treatment for OA are discussed. This article provides a comprehensive summary of key cells that might be targets of future therapies for OA. |
| first_indexed | 2024-12-13T20:41:51Z |
| format | Article |
| id | doaj.art-43864a5a6c13433e976b0c8cfbcc388c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T20:41:51Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-43864a5a6c13433e976b0c8cfbcc388c2022-12-21T23:32:08ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.720477720477Cell Interplay in OsteoarthritisZihao Li0Ziyu Huang1Lunhao Bai2Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaForeign Languages College, Shanghai Normal University, Shanghai, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaOsteoarthritis (OA) is a common chronic disease and a significant health concern that needs to be urgently solved. OA affects the cartilage and entire joint tissues, including the subchondral bone, synovium, and infrapatellar fat pads. The physiological and pathological changes in these tissues affect the occurrence and development of OA. Understanding complex crosstalk among different joint tissues and their roles in OA initiation and progression is critical in elucidating the pathogenic mechanism of OA. In this review, we begin with an overview of the role of chondrocytes, synovial cells (synovial fibroblasts and macrophages), mast cells, osteoblasts, osteoclasts, various stem cells, and engineered cells (induced pluripotent stem cells) in OA pathogenesis. Then, we discuss the various mechanisms by which these cells communicate, including paracrine signaling, local microenvironment, co-culture, extracellular vesicles (exosomes), and cell tissue engineering. We particularly focus on the therapeutic potential and clinical applications of stem cell-derived extracellular vesicles, which serve as modulators of cell-to-cell communication, in the field of regenerative medicine, such as cartilage repair. Finally, the challenges and limitations related to exosome-based treatment for OA are discussed. This article provides a comprehensive summary of key cells that might be targets of future therapies for OA.https://www.frontiersin.org/articles/10.3389/fcell.2021.720477/fullcartilagesubchondral bonesynoviuminfrapatellar fat padstem cellexosome |
| spellingShingle | Zihao Li Ziyu Huang Lunhao Bai Cell Interplay in Osteoarthritis Frontiers in Cell and Developmental Biology cartilage subchondral bone synovium infrapatellar fat pad stem cell exosome |
| title | Cell Interplay in Osteoarthritis |
| title_full | Cell Interplay in Osteoarthritis |
| title_fullStr | Cell Interplay in Osteoarthritis |
| title_full_unstemmed | Cell Interplay in Osteoarthritis |
| title_short | Cell Interplay in Osteoarthritis |
| title_sort | cell interplay in osteoarthritis |
| topic | cartilage subchondral bone synovium infrapatellar fat pad stem cell exosome |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.720477/full |
| work_keys_str_mv | AT zihaoli cellinterplayinosteoarthritis AT ziyuhuang cellinterplayinosteoarthritis AT lunhaobai cellinterplayinosteoarthritis |