Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases
AbstractObjective To describe the reproductive outcomes of patients with diffuse uterine leiomyomatosis (DUL) treated with high-intensity focused ultrasound (HIFU) ablation.Materials and methods Three patients of reproductive age with DUL who underwent HIFU treatment were enrolled, all of whom had a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2234674 |
| _version_ | 1797374212903534592 |
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| author | Chunmei Gong Zhenjiang Lin Yongbin Deng Bing Yang Lian Zhang |
| author_facet | Chunmei Gong Zhenjiang Lin Yongbin Deng Bing Yang Lian Zhang |
| author_sort | Chunmei Gong |
| collection | DOAJ |
| description | AbstractObjective To describe the reproductive outcomes of patients with diffuse uterine leiomyomatosis (DUL) treated with high-intensity focused ultrasound (HIFU) ablation.Materials and methods Three patients of reproductive age with DUL who underwent HIFU treatment were enrolled, all of whom had a strong desire to become pregnant. All patients underwent routine laboratory tests, electrocardiography (ECG), chest X-ray radiography, ultrasound, and magnetic resonance imaging (MRI) examinations after routine medical history collection and physical examination. The treatment time, treatment power, sonication time, and adverse events were recorded. One day after HIFU, MRI was performed to evaluate treatment efficacy. The patients were scheduled for follow-up at 3-, 6-, 12-, and 24-month after HIFU treatment.Results All the three patients completed HIFU treatment successfully without any major complication. Uterine size and menstrual volume significantly decreased with the combination of medical and HIFU treatments. The shrinkage rate of uterine volume was 31–44% and the menstrual volume reduced by 1/2 or returned to normal at 3 months post-HIFU. Three patients had successful conceptions between 3 and 11 months after HIFU with healthy deliveries. No uterine rupture occurred during pregnancy and delivery.Conclusion HIFU ablation may help achieve a successful pregnancy in patients with DUL. |
| first_indexed | 2024-03-08T19:02:39Z |
| format | Article |
| id | doaj.art-4389a86ad6d0498dbffadcb0f84d5178 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:39Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-4389a86ad6d0498dbffadcb0f84d51782023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2023.2234674Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three casesChunmei Gong0Zhenjiang Lin1Yongbin Deng2Bing Yang3Lian Zhang4Department of Gynecology, Chongqing Haifu Hospital, Chongqing, P.R. ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Gynecology, Chongqing Haifu Hospital, Chongqing, P.R. ChinaDepartment of Gynaecology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizou, P.R. ChinaDepartment of Gynecology, Chongqing Haifu Hospital, Chongqing, P.R. ChinaAbstractObjective To describe the reproductive outcomes of patients with diffuse uterine leiomyomatosis (DUL) treated with high-intensity focused ultrasound (HIFU) ablation.Materials and methods Three patients of reproductive age with DUL who underwent HIFU treatment were enrolled, all of whom had a strong desire to become pregnant. All patients underwent routine laboratory tests, electrocardiography (ECG), chest X-ray radiography, ultrasound, and magnetic resonance imaging (MRI) examinations after routine medical history collection and physical examination. The treatment time, treatment power, sonication time, and adverse events were recorded. One day after HIFU, MRI was performed to evaluate treatment efficacy. The patients were scheduled for follow-up at 3-, 6-, 12-, and 24-month after HIFU treatment.Results All the three patients completed HIFU treatment successfully without any major complication. Uterine size and menstrual volume significantly decreased with the combination of medical and HIFU treatments. The shrinkage rate of uterine volume was 31–44% and the menstrual volume reduced by 1/2 or returned to normal at 3 months post-HIFU. Three patients had successful conceptions between 3 and 11 months after HIFU with healthy deliveries. No uterine rupture occurred during pregnancy and delivery.Conclusion HIFU ablation may help achieve a successful pregnancy in patients with DUL.https://www.tandfonline.com/doi/10.1080/02656736.2023.2234674Diffuse uterine leiomyomatosisHIFUGnRHapregnancycomplication |
| spellingShingle | Chunmei Gong Zhenjiang Lin Yongbin Deng Bing Yang Lian Zhang Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases International Journal of Hyperthermia Diffuse uterine leiomyomatosis HIFU GnRHa pregnancy complication |
| title | Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases |
| title_full | Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases |
| title_fullStr | Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases |
| title_full_unstemmed | Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases |
| title_short | Successful pregnancies in women with diffuse uterine leiomyomatosis after high-intensity focused ultrasound ablation: report of three cases |
| title_sort | successful pregnancies in women with diffuse uterine leiomyomatosis after high intensity focused ultrasound ablation report of three cases |
| topic | Diffuse uterine leiomyomatosis HIFU GnRHa pregnancy complication |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2234674 |
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