Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review
Abstract Background Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a non-melanoma skin cancer that is mostly caused by solar ultraviolet radiation exposure. While it usually has an excellent prognosis, a subset of patients (5%) develops nodal metastasis and has poor outcomes. The aim of...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-09-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40463-021-00529-7 |
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| author | Joshua Lubov Mathilde Labbé Krystelle Sioufi Grégoire B. Morand Michael P. Hier Manish Khanna Khalil Sultanem Alex M. Mlynarek |
| author_facet | Joshua Lubov Mathilde Labbé Krystelle Sioufi Grégoire B. Morand Michael P. Hier Manish Khanna Khalil Sultanem Alex M. Mlynarek |
| author_sort | Joshua Lubov |
| collection | DOAJ |
| description | Abstract Background Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a non-melanoma skin cancer that is mostly caused by solar ultraviolet radiation exposure. While it usually has an excellent prognosis, a subset of patients (5%) develops nodal metastasis and has poor outcomes. The aim of this study was to systematically review the literature and evaluate the prognostic factors of HNCSCC in order to better understand which patients are the most likely to develop metastatic disease. Methods A comprehensive literature search was performed on PubMed and EMBASE to identify the studies that evaluated the prognostic factors of HNCSCC. Prognostic factors were deemed significant if they had a reported p-value of < 0.05. Proportions of studies that reported a given factor to be statistically significant were calculated for each prognostic factor. Results The search yielded a total of 958 citations. Forty studies, involving a total of 8535 patients, were included in the final analysis. The pre-operative/clinical prognostic factors with the highest proportion of significance were state of immunosuppression (73.3%) and age (53.3%); while post-operative/pathological prognostic factors of importance were number of lymph nodes involved with carcinoma (70.0%), margins involved with carcinoma (66.7%), and tumor depth (50.0%). Conclusion This systematic review is aimed to aid physicians in assessing the prognosis of HNCSCC and identifying the subsets of patients that are most susceptible to metastasis. It also suggests that immunosuppressed patients with a high-risk feature on biopsy, such as invasion beyond subcutaneous fat, could possibly benefit from a sentinel lymph node biopsy. Graphical abstract |
| first_indexed | 2024-04-11T03:03:45Z |
| format | Article |
| id | doaj.art-438cefb1171c48919648f60058211b8f |
| institution | Directory Open Access Journal |
| issn | 1916-0216 |
| language | English |
| last_indexed | 2025-02-17T07:41:07Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj.art-438cefb1171c48919648f60058211b8f2025-01-03T01:45:48ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162021-09-0150111010.1186/s40463-021-00529-7Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic reviewJoshua Lubov0Mathilde Labbé1Krystelle Sioufi2Grégoire B. Morand3Michael P. Hier4Manish Khanna5Khalil Sultanem6Alex M. Mlynarek7Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityDepartment of Dermatology, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityDepartment of Radiation Oncology, Sir Mortimer B. Davis-Jewish General Hospital, McGill UniversityDepartment of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General HospitalMcGill UniversityAbstract Background Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a non-melanoma skin cancer that is mostly caused by solar ultraviolet radiation exposure. While it usually has an excellent prognosis, a subset of patients (5%) develops nodal metastasis and has poor outcomes. The aim of this study was to systematically review the literature and evaluate the prognostic factors of HNCSCC in order to better understand which patients are the most likely to develop metastatic disease. Methods A comprehensive literature search was performed on PubMed and EMBASE to identify the studies that evaluated the prognostic factors of HNCSCC. Prognostic factors were deemed significant if they had a reported p-value of < 0.05. Proportions of studies that reported a given factor to be statistically significant were calculated for each prognostic factor. Results The search yielded a total of 958 citations. Forty studies, involving a total of 8535 patients, were included in the final analysis. The pre-operative/clinical prognostic factors with the highest proportion of significance were state of immunosuppression (73.3%) and age (53.3%); while post-operative/pathological prognostic factors of importance were number of lymph nodes involved with carcinoma (70.0%), margins involved with carcinoma (66.7%), and tumor depth (50.0%). Conclusion This systematic review is aimed to aid physicians in assessing the prognosis of HNCSCC and identifying the subsets of patients that are most susceptible to metastasis. It also suggests that immunosuppressed patients with a high-risk feature on biopsy, such as invasion beyond subcutaneous fat, could possibly benefit from a sentinel lymph node biopsy. Graphical abstracthttps://doi.org/10.1186/s40463-021-00529-7CarcinomaSquamous cellSentinel lymph node biopsyMohs surgerySkin neoplasmsSquamous cell carcinoma of head and neck |
| spellingShingle | Joshua Lubov Mathilde Labbé Krystelle Sioufi Grégoire B. Morand Michael P. Hier Manish Khanna Khalil Sultanem Alex M. Mlynarek Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review Journal of Otolaryngology - Head and Neck Surgery Carcinoma Squamous cell Sentinel lymph node biopsy Mohs surgery Skin neoplasms Squamous cell carcinoma of head and neck |
| title | Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review |
| title_full | Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review |
| title_fullStr | Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review |
| title_full_unstemmed | Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review |
| title_short | Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review |
| title_sort | prognostic factors of head and neck cutaneous squamous cell carcinoma a systematic review |
| topic | Carcinoma Squamous cell Sentinel lymph node biopsy Mohs surgery Skin neoplasms Squamous cell carcinoma of head and neck |
| url | https://doi.org/10.1186/s40463-021-00529-7 |
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