Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation
Low circulating levels of total 25-hydroxyvitamin D (25(OH)D) have been associated with an increased risk of adverse effects after cardiac surgery. The metabolites, 25(OH)D2 and 25(OH)D3, provide a good index of vitamin D status. In this study, we examined the association between preoperative plasma...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2016-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679015000385/type/journal_article |
| _version_ | 1811155911590281216 |
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| author | G. V. Skuladottir A. Cohen D. O. Arnar D. M. Hougaard B. Torfason R. Palsson O. S. Indridason |
| author_facet | G. V. Skuladottir A. Cohen D. O. Arnar D. M. Hougaard B. Torfason R. Palsson O. S. Indridason |
| author_sort | G. V. Skuladottir |
| collection | DOAJ |
| description | Low circulating levels of total 25-hydroxyvitamin D (25(OH)D) have been associated with an increased risk of adverse effects after cardiac surgery. The metabolites, 25(OH)D2 and 25(OH)D3, provide a good index of vitamin D status. In this study, we examined the association between preoperative plasma levels of total 25(OH)D, 25(OH)D2 and 25(OH)D3 and the risk of postoperative atrial fibrillation (POAF) following open heart surgery. The levels of plasma 25(OH)D2 and 25(OH)D3 in 118 patients, who underwent coronary artery bypass grafting and/or valvular surgery, were measured immediately prior to surgery and on postoperative day 3 by liquid chromatography–tandem mass spectrometry. Patients who developed POAF had higher median plasma levels of 25(OH)D2 than those who remained in sinus rhythm (SR) (P = 0·003), but no significant difference was noted in levels of 25(OH)D3 or total 25(OH)D between the two groups (P > 0·05). By univariate analysis, patients with total 25(OH)D and 25(OH)D2 levels above the median had higher frequency of POAF (P < 0·05) and the incidence of POAF increased significantly with each higher quartile of preoperative plasma levels of 25(OH)D2 (P = 0·001), an association that was independent of confounding factors. In both the SR and POAF groups, the median plasma levels of 25(OH)D2, 25(OH)D3 and total 25(OH)D were lower (P < 0·05) on the third postoperative day compared with preoperatively. Our findings demonstrate that higher plasma levels of 25(OH)D2 are associated with increased risk of POAF, while this is not the case for 25(OH)D3 or total 25(OH)D. The reason for these discrepant results is not clear but warrants further study. |
| first_indexed | 2024-04-10T04:42:43Z |
| format | Article |
| id | doaj.art-438d20d137dc4c3f9aa212ddbfa311d3 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:42:43Z |
| publishDate | 2016-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-438d20d137dc4c3f9aa212ddbfa311d32023-03-09T12:38:49ZengCambridge University PressJournal of Nutritional Science2048-67902016-01-01510.1017/jns.2015.38Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillationG. V. Skuladottir0A. Cohen1D. O. Arnar2D. M. Hougaard3B. Torfason4R. Palsson5O. S. Indridason6Department of Physiology, School of Health Sciences, University of Iceland, Reykjavik, Iceland Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, IcelandDepartment of Congenital Disorders, Statens Serum Institute, Copenhagen, DenmarkFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Internal Medicine Services, Landspitali – The National University Hospital of Iceland, Reykjavik, IcelandDepartment of Congenital Disorders, Statens Serum Institute, Copenhagen, DenmarkFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Surgical Services, Landspitali – The National University Hospital of Iceland, Reykjavik, IcelandFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland Internal Medicine Services, Landspitali – The National University Hospital of Iceland, Reykjavik, IcelandInternal Medicine Services, Landspitali – The National University Hospital of Iceland, Reykjavik, IcelandLow circulating levels of total 25-hydroxyvitamin D (25(OH)D) have been associated with an increased risk of adverse effects after cardiac surgery. The metabolites, 25(OH)D2 and 25(OH)D3, provide a good index of vitamin D status. In this study, we examined the association between preoperative plasma levels of total 25(OH)D, 25(OH)D2 and 25(OH)D3 and the risk of postoperative atrial fibrillation (POAF) following open heart surgery. The levels of plasma 25(OH)D2 and 25(OH)D3 in 118 patients, who underwent coronary artery bypass grafting and/or valvular surgery, were measured immediately prior to surgery and on postoperative day 3 by liquid chromatography–tandem mass spectrometry. Patients who developed POAF had higher median plasma levels of 25(OH)D2 than those who remained in sinus rhythm (SR) (P = 0·003), but no significant difference was noted in levels of 25(OH)D3 or total 25(OH)D between the two groups (P > 0·05). By univariate analysis, patients with total 25(OH)D and 25(OH)D2 levels above the median had higher frequency of POAF (P < 0·05) and the incidence of POAF increased significantly with each higher quartile of preoperative plasma levels of 25(OH)D2 (P = 0·001), an association that was independent of confounding factors. In both the SR and POAF groups, the median plasma levels of 25(OH)D2, 25(OH)D3 and total 25(OH)D were lower (P < 0·05) on the third postoperative day compared with preoperatively. Our findings demonstrate that higher plasma levels of 25(OH)D2 are associated with increased risk of POAF, while this is not the case for 25(OH)D3 or total 25(OH)D. The reason for these discrepant results is not clear but warrants further study.https://www.cambridge.org/core/product/identifier/S2048679015000385/type/journal_articleAtrial fibrillationHeart surgeryPostoperative stateVitamin D |
| spellingShingle | G. V. Skuladottir A. Cohen D. O. Arnar D. M. Hougaard B. Torfason R. Palsson O. S. Indridason Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation Journal of Nutritional Science Atrial fibrillation Heart surgery Postoperative state Vitamin D |
| title | Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation |
| title_full | Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation |
| title_fullStr | Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation |
| title_full_unstemmed | Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation |
| title_short | Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation |
| title_sort | plasma 25 hydroxyvitamin d2 and d3 levels and incidence of postoperative atrial fibrillation |
| topic | Atrial fibrillation Heart surgery Postoperative state Vitamin D |
| url | https://www.cambridge.org/core/product/identifier/S2048679015000385/type/journal_article |
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