HER2 induces expression of leptin in human breast epithelial cells
A close association between the obesity hormone leptin andbreast cancer progression has been suggested. The presentstudy investigated the molecular mechanism for enhancedleptin expression in breast cancer cells and its functionalsignificance in breast cancer aggressiveness. We examinedwhether leptin...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2012-12-01
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| Series: | BMB Reports |
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| Online Access: | http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTE0MTVAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0xMiU1RDEyMTIyNjE2MzJfJTI4NzE5LTcyMyUyOUJNQl8xMi0xNjQucGRm |
| _version_ | 1819126677941256192 |
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| author | Aree Moon |
| author_facet | Aree Moon |
| author_sort | Aree Moon |
| collection | DOAJ |
| description | A close association between the obesity hormone leptin andbreast cancer progression has been suggested. The presentstudy investigated the molecular mechanism for enhancedleptin expression in breast cancer cells and its functionalsignificance in breast cancer aggressiveness. We examinedwhether leptin expression level is affected by the oncoproteinhuman epidermal growth factor receptor2 (HER2), which isoverexpressed in ∼30% of breast tumors. Here, we report, forthe first time, that HER2 induces transcriptional activation ofleptin in MCF10A human breast epithelial cells. We alsoshowed that p38 mitogen-activated protein kinase signalingwas involved in leptin expression induced by HER2. Weshowed a crucial role of leptin in the invasiveness ofHER2-MCF10A cells using an siRNA molecule targeting leptin.Taken together, the results indicate a molecular link betweenHER2 and leptin, providing supporting evidence that leptinrepresents a target for breast cancer therapy. |
| first_indexed | 2024-12-22T07:59:51Z |
| format | Article |
| id | doaj.art-438e040e4d4d4390aebefcd89d410261 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-22T07:59:51Z |
| publishDate | 2012-12-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-438e040e4d4d4390aebefcd89d4102612022-12-21T18:33:17ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2012-12-014512719723HER2 induces expression of leptin in human breast epithelial cellsAree MoonA close association between the obesity hormone leptin andbreast cancer progression has been suggested. The presentstudy investigated the molecular mechanism for enhancedleptin expression in breast cancer cells and its functionalsignificance in breast cancer aggressiveness. We examinedwhether leptin expression level is affected by the oncoproteinhuman epidermal growth factor receptor2 (HER2), which isoverexpressed in ∼30% of breast tumors. Here, we report, forthe first time, that HER2 induces transcriptional activation ofleptin in MCF10A human breast epithelial cells. We alsoshowed that p38 mitogen-activated protein kinase signalingwas involved in leptin expression induced by HER2. Weshowed a crucial role of leptin in the invasiveness ofHER2-MCF10A cells using an siRNA molecule targeting leptin.Taken together, the results indicate a molecular link betweenHER2 and leptin, providing supporting evidence that leptinrepresents a target for breast cancer therapy.http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTE0MTVAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0xMiU1RDEyMTIyNjE2MzJfJTI4NzE5LTcyMyUyOUJNQl8xMi0xNjQucGRmBreast cancerErBb2HER2Leptin |
| spellingShingle | Aree Moon HER2 induces expression of leptin in human breast epithelial cells BMB Reports Breast cancer ErBb2 HER2 Leptin |
| title | HER2 induces expression of leptin in human breast epithelial cells |
| title_full | HER2 induces expression of leptin in human breast epithelial cells |
| title_fullStr | HER2 induces expression of leptin in human breast epithelial cells |
| title_full_unstemmed | HER2 induces expression of leptin in human breast epithelial cells |
| title_short | HER2 induces expression of leptin in human breast epithelial cells |
| title_sort | her2 induces expression of leptin in human breast epithelial cells |
| topic | Breast cancer ErBb2 HER2 Leptin |
| url | http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTE0MTVAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0xMiU1RDEyMTIyNjE2MzJfJTI4NzE5LTcyMyUyOUJNQl8xMi0xNjQucGRm |
| work_keys_str_mv | AT areemoon her2inducesexpressionofleptininhumanbreastepithelialcells |