Evaluation of Inflammatory markers in different stages of Chronic Renal Disease
Background: Chronic kidney disease (CKD) refers to a long-term loss of kidney function. The progression of CKD leads to the damage of other organs including cardiovascular disease which increased the risk of mortality. Early detection of kidney failure can slow down the end-stage renal disease. A...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-05-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/40454 |
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| author | Farha Khan Sangeeta Kapoor Jyoti Rana Saba Khan |
| author_facet | Farha Khan Sangeeta Kapoor Jyoti Rana Saba Khan |
| author_sort | Farha Khan |
| collection | DOAJ |
| description | Background: Chronic kidney disease (CKD) refers to a long-term loss of kidney function. The progression of CKD leads to the damage of other organs including cardiovascular disease which increased the risk of mortality. Early detection of kidney failure can slow down the end-stage renal disease.
Aims and Objectives: To estimate the inflammatory marker Adenosine deaminase (ADA) activity in different stages of CKD. To correlate the level of ADA activity with Serum Creatinine with different stages of CKD on the basis of estimated glomerular filtration rate (eGFR).
Materials and Methods: The participants having age more than 18 and <60 years having CKD have been enrolled as a study group. CKD was confirmed by calculating eGFR using Cockcroft-Gault equation, plasma creatinine estimation done in all the patients. This study was approved by the Ethical Committee of TMMC and RC.
Results: It is observed that the incidence of CKD reaches its maximum strength during middle age. 28% of the young patients, i.e., 45 years of age or younger at the time of CKD, had increased level of ADA. Serum levels of ADA, Creatinine were higher among participants with lower level of eGFR. Inflammation was higher among those with lower eGFR. All biochemical parameter (ADA, CRP, ESR) shows the negative correlation with eGFR. eGFR shows a negative highly significant correlation withESR with a correlation coefficient of r=−4.702 (P<0.001).
Conclusion: With the progression of Kidney disease (CKD stages 1–5) it comes to significantly increase of inflammatory markers as decrease in the eGFR with statistical significance. Inflammatory Biomarkers were inversely associated with the measure of kidney function. It is clear that a single indicator of renal function is not sufficient in evaluating the kidney disease stage. |
| first_indexed | 2024-12-10T09:41:07Z |
| format | Article |
| id | doaj.art-438e2b3016a94274b3f018b974a79fe5 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-10T09:41:07Z |
| publishDate | 2022-05-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-438e2b3016a94274b3f018b974a79fe52022-12-22T01:53:59ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-05-01135100107https://doi.org/10.3126/ajms.v13i5.40454Evaluation of Inflammatory markers in different stages of Chronic Renal DiseaseFarha Khan 0https://orcid.org/0000-0001-8441-6019Sangeeta Kapoor 1Jyoti Rana 2Saba Khan 3Tutor, Department of Biochemistry, All India Institute of Medical Science, Kalyani, West Bengal Professor and Head, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Center, BagadpurTutor, Department of Biochemistry, Varun Arjun Medical College and Rohilkhand Hospital, BantharaTutor, Department of Biochemistry, Autonomous State Medical College Fatehpur, Fatehpur, Uttar Pradesh, IndiaBackground: Chronic kidney disease (CKD) refers to a long-term loss of kidney function. The progression of CKD leads to the damage of other organs including cardiovascular disease which increased the risk of mortality. Early detection of kidney failure can slow down the end-stage renal disease. Aims and Objectives: To estimate the inflammatory marker Adenosine deaminase (ADA) activity in different stages of CKD. To correlate the level of ADA activity with Serum Creatinine with different stages of CKD on the basis of estimated glomerular filtration rate (eGFR). Materials and Methods: The participants having age more than 18 and <60 years having CKD have been enrolled as a study group. CKD was confirmed by calculating eGFR using Cockcroft-Gault equation, plasma creatinine estimation done in all the patients. This study was approved by the Ethical Committee of TMMC and RC. Results: It is observed that the incidence of CKD reaches its maximum strength during middle age. 28% of the young patients, i.e., 45 years of age or younger at the time of CKD, had increased level of ADA. Serum levels of ADA, Creatinine were higher among participants with lower level of eGFR. Inflammation was higher among those with lower eGFR. All biochemical parameter (ADA, CRP, ESR) shows the negative correlation with eGFR. eGFR shows a negative highly significant correlation withESR with a correlation coefficient of r=−4.702 (P<0.001). Conclusion: With the progression of Kidney disease (CKD stages 1–5) it comes to significantly increase of inflammatory markers as decrease in the eGFR with statistical significance. Inflammatory Biomarkers were inversely associated with the measure of kidney function. It is clear that a single indicator of renal function is not sufficient in evaluating the kidney disease stage.https://www.nepjol.info/index.php/AJMS/article/view/40454adenosine deaminasechronic kidney diseaseestimated glomerular filtration ratec-reactive protein |
| spellingShingle | Farha Khan Sangeeta Kapoor Jyoti Rana Saba Khan Evaluation of Inflammatory markers in different stages of Chronic Renal Disease Asian Journal of Medical Sciences adenosine deaminase chronic kidney disease estimated glomerular filtration rate c-reactive protein |
| title | Evaluation of Inflammatory markers in different stages of Chronic Renal Disease |
| title_full | Evaluation of Inflammatory markers in different stages of Chronic Renal Disease |
| title_fullStr | Evaluation of Inflammatory markers in different stages of Chronic Renal Disease |
| title_full_unstemmed | Evaluation of Inflammatory markers in different stages of Chronic Renal Disease |
| title_short | Evaluation of Inflammatory markers in different stages of Chronic Renal Disease |
| title_sort | evaluation of inflammatory markers in different stages of chronic renal disease |
| topic | adenosine deaminase chronic kidney disease estimated glomerular filtration rate c-reactive protein |
| url | https://www.nepjol.info/index.php/AJMS/article/view/40454 |
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