Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial
Abstract. Objectives:. Timing of drain removal and its effects on complications after major pancreatectomy remain controversial. We designed this study to assess whether early drain removal after major pancreatectomy influences the incidence of complications in the patients with low risk of postoper...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2020-06-01
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| Series: | Journal of Pancreatology |
| Online Access: | http://journals.lww.com/10.1097/JP9.0000000000000049 |
| _version_ | 1819135437355089920 |
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| author | Menghua Dai, MD Qiaofei Liu, MD Cheng Xing, MD Jorg Kleeff, MD, FACS Quan Liao, MD Junchao Guo, MD Xianlin Han, MD Qiang Xu, MD Shunda Wang, MD |
| author_facet | Menghua Dai, MD Qiaofei Liu, MD Cheng Xing, MD Jorg Kleeff, MD, FACS Quan Liao, MD Junchao Guo, MD Xianlin Han, MD Qiang Xu, MD Shunda Wang, MD |
| author_sort | Menghua Dai, MD |
| collection | DOAJ |
| description | Abstract. Objectives:. Timing of drain removal and its effects on complications after major pancreatectomy remain controversial. We designed this study to assess whether early drain removal after major pancreatectomy influences the incidence of complications in the patients with low risk of postoperative pancreatic fistula (POPF).
Methods:. This is a single-center randomized controlled trial (RCT). A total of 144 patients undergoing pancreaticoduodenectomy (PD) and distal pancreatectomy (DP) who met the criteria, including drain amylase on postoperative day (POD) 1 and 3 less than 5000 U/L and drain output within POD 3 less than 300 mL/d, were randomly assigned to early drain removal (POD 3) or standard drain removal (≥POD 5). The primary outcome was major complications (Clavien-Dindo grades 2–4), and the secondary outcome was POPF, reintervention treatment, readmission, and total medical expense within 3 months after surgery.
Results:. A total of 5 patients in early drain removal group had at least 1 major complications (grades 2–4), compared to 15 patients in standard drain removal group (P = .028). The incidence of grade B/C pancreatic fistula was not significantly different (2.8% vs 0%). Multivariate analysis demonstrated that early drain removal was an independent factor associated with a reduced risk of major complications (P = .039, odds ratio = 0.314). Majority of major complications occurred in PD patients, and only very few cases occurred in DP patients. Stratified analysis showed that early drain removal significantly reduced the major complications only in the patients undergoing PD.
Conclusion:. This single-center RCT shows early drain removal on POD 3 is safe for both DP and PD patients, under our criteria. Early drain removal could reduce the incidence of major complications in patients undergoing PD. |
| first_indexed | 2024-12-22T10:19:04Z |
| format | Article |
| id | doaj.art-438e7c73fcdf458bbf393000c1fcd888 |
| institution | Directory Open Access Journal |
| issn | 2096-5664 2577-3577 |
| language | English |
| last_indexed | 2024-12-22T10:19:04Z |
| publishDate | 2020-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Journal of Pancreatology |
| spelling | doaj.art-438e7c73fcdf458bbf393000c1fcd8882022-12-21T18:29:39ZengWolters Kluwer Health/LWWJournal of Pancreatology2096-56642577-35772020-06-01329310010.1097/JP9.0000000000000049202006000-00006Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trialMenghua Dai, MDQiaofei Liu, MDCheng Xing, MDJorg Kleeff, MD, FACSQuan Liao, MDJunchao Guo, MDXianlin Han, MDQiang Xu, MDShunda Wang, MDAbstract. Objectives:. Timing of drain removal and its effects on complications after major pancreatectomy remain controversial. We designed this study to assess whether early drain removal after major pancreatectomy influences the incidence of complications in the patients with low risk of postoperative pancreatic fistula (POPF). Methods:. This is a single-center randomized controlled trial (RCT). A total of 144 patients undergoing pancreaticoduodenectomy (PD) and distal pancreatectomy (DP) who met the criteria, including drain amylase on postoperative day (POD) 1 and 3 less than 5000 U/L and drain output within POD 3 less than 300 mL/d, were randomly assigned to early drain removal (POD 3) or standard drain removal (≥POD 5). The primary outcome was major complications (Clavien-Dindo grades 2–4), and the secondary outcome was POPF, reintervention treatment, readmission, and total medical expense within 3 months after surgery. Results:. A total of 5 patients in early drain removal group had at least 1 major complications (grades 2–4), compared to 15 patients in standard drain removal group (P = .028). The incidence of grade B/C pancreatic fistula was not significantly different (2.8% vs 0%). Multivariate analysis demonstrated that early drain removal was an independent factor associated with a reduced risk of major complications (P = .039, odds ratio = 0.314). Majority of major complications occurred in PD patients, and only very few cases occurred in DP patients. Stratified analysis showed that early drain removal significantly reduced the major complications only in the patients undergoing PD. Conclusion:. This single-center RCT shows early drain removal on POD 3 is safe for both DP and PD patients, under our criteria. Early drain removal could reduce the incidence of major complications in patients undergoing PD.http://journals.lww.com/10.1097/JP9.0000000000000049 |
| spellingShingle | Menghua Dai, MD Qiaofei Liu, MD Cheng Xing, MD Jorg Kleeff, MD, FACS Quan Liao, MD Junchao Guo, MD Xianlin Han, MD Qiang Xu, MD Shunda Wang, MD Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial Journal of Pancreatology |
| title | Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial |
| title_full | Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial |
| title_fullStr | Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial |
| title_full_unstemmed | Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial |
| title_short | Early drain removal after major pancreatectomy reduces postoperative complications: a single-center, randomized, controlled trial |
| title_sort | early drain removal after major pancreatectomy reduces postoperative complications a single center randomized controlled trial |
| url | http://journals.lww.com/10.1097/JP9.0000000000000049 |
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