Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease
Abstract Background Parkinson's disease (PD) is one of the most common neurodegenerative disorders that seriously impair the life quality and survival of patients. Herein, we aim to investigate the neuroprotective roles of brain‐derived neurotrophic factor (BDNF) in PD mice and reveal the under...
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2251 |
| _version_ | 1827877374905024512 |
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| author | E Chang Jiongmei Wang |
| author_facet | E Chang Jiongmei Wang |
| author_sort | E Chang |
| collection | DOAJ |
| description | Abstract Background Parkinson's disease (PD) is one of the most common neurodegenerative disorders that seriously impair the life quality and survival of patients. Herein, we aim to investigate the neuroprotective roles of brain‐derived neurotrophic factor (BDNF) in PD mice and reveal the underlying mechanisms. BDNF overexpression was achieved via the injection of adeno‐associated viruses (AAV) with BDNF gene. Methods PD mouse model was established by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) treatment. Tests of rotarod, pole, open field, and novel object recognition were conducted to evaluate the motor and cognitive functions of treated mice. Results Mitochondrial impairment, mitochondrial respiratory chain enzymes, and tyrosine hydroxylase (TH)‐positive dopaminergic neurons were detected to uncover the molecular mechanism. BDNF overexpression attenuated motor deficits and cognitive impairment in MPTP‐induced PD mice. Mechanistically, BDNF mitigated mitochondrial impairment increased the activity of respiratory chain Complex I and Ⅱ+III, and finally alleviated TH‐positive dopaminergic neuron loss in MPTP‐induced PD mice. Conclusion This study highlights the potential of BDNF as a therapeutic candidate for the treatment of mitochondrial impairment‐associated neurodegenerative diseases. |
| first_indexed | 2024-03-12T17:36:31Z |
| format | Article |
| id | doaj.art-438e91ea7c8f4c03957df909745e9d4f |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:36:31Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-438e91ea7c8f4c03957df909745e9d4f2023-08-04T10:56:25ZengWileyBrain and Behavior2162-32792021-08-01118n/an/a10.1002/brb3.2251Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's diseaseE Chang0Jiongmei Wang1Department of Rehabilitation Medicine Cangzhou Central Hospital Cangzhou Hebei ChinaDepartment of Rehabilitation Medicine Cangzhou Central Hospital Cangzhou Hebei ChinaAbstract Background Parkinson's disease (PD) is one of the most common neurodegenerative disorders that seriously impair the life quality and survival of patients. Herein, we aim to investigate the neuroprotective roles of brain‐derived neurotrophic factor (BDNF) in PD mice and reveal the underlying mechanisms. BDNF overexpression was achieved via the injection of adeno‐associated viruses (AAV) with BDNF gene. Methods PD mouse model was established by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) treatment. Tests of rotarod, pole, open field, and novel object recognition were conducted to evaluate the motor and cognitive functions of treated mice. Results Mitochondrial impairment, mitochondrial respiratory chain enzymes, and tyrosine hydroxylase (TH)‐positive dopaminergic neurons were detected to uncover the molecular mechanism. BDNF overexpression attenuated motor deficits and cognitive impairment in MPTP‐induced PD mice. Mechanistically, BDNF mitigated mitochondrial impairment increased the activity of respiratory chain Complex I and Ⅱ+III, and finally alleviated TH‐positive dopaminergic neuron loss in MPTP‐induced PD mice. Conclusion This study highlights the potential of BDNF as a therapeutic candidate for the treatment of mitochondrial impairment‐associated neurodegenerative diseases.https://doi.org/10.1002/brb3.2251BDNFbehaviordopaminergic neuronmitochondriaParkinson's disease |
| spellingShingle | E Chang Jiongmei Wang Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease Brain and Behavior BDNF behavior dopaminergic neuron mitochondria Parkinson's disease |
| title | Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease |
| title_full | Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease |
| title_fullStr | Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease |
| title_full_unstemmed | Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease |
| title_short | Brain‐derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease |
| title_sort | brain derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of parkinson s disease |
| topic | BDNF behavior dopaminergic neuron mitochondria Parkinson's disease |
| url | https://doi.org/10.1002/brb3.2251 |
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