Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy
Abstract The treatment of cancer patients with α‐particle‐emitting therapeutics continues to gain in importance and relevance. The range of radiopharmaceutically relevant α‐emitters is limited to a few radionuclides, as stable chelators or carrier systems for safe transport of the radioactive cargo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2020-08-01
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| Series: | ChemistryOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/open.202000126 |
| _version_ | 1818457713190895616 |
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| author | Falco Reissig Dr. Kristof Zarschler Dr. René Hübner Dr. Hans‐Jürgen Pietzsch Prof. Dr. Klaus Kopka Dr. Constantin Mamat |
| author_facet | Falco Reissig Dr. Kristof Zarschler Dr. René Hübner Dr. Hans‐Jürgen Pietzsch Prof. Dr. Klaus Kopka Dr. Constantin Mamat |
| author_sort | Falco Reissig |
| collection | DOAJ |
| description | Abstract The treatment of cancer patients with α‐particle‐emitting therapeutics continues to gain in importance and relevance. The range of radiopharmaceutically relevant α‐emitters is limited to a few radionuclides, as stable chelators or carrier systems for safe transport of the radioactive cargo are often lacking. Encapsulation of α‐emitters into solid inorganic systems can help to diversify the portfolio of candidate radionuclides, provided, that these nanomaterials effectively retain both the parent and the recoil daughters. We therefore focus on designing stable and defined nanocarrier‐based systems for various clinically relevant radionuclides, including the promising α‐emitting radionuclide 224Ra. Hence, sub‐10 nm barium sulfate nanocontainers were prepared and different radiometals like 89Zr, 111In, 131Ba, 177Lu or 224Ra were incorporated. Our system shows stabilities of >90 % regarding the radiometal release from the BaSO4 matrix. Furthermore, we confirm the presence of surface‐exposed amine functionalities as well as the formation of a biomolecular corona. |
| first_indexed | 2024-12-14T22:46:56Z |
| format | Article |
| id | doaj.art-438f32c0cb654ab9b3871122b6845a96 |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-12-14T22:46:56Z |
| publishDate | 2020-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-438f32c0cb654ab9b3871122b6845a962022-12-21T22:44:49ZengWiley-VCHChemistryOpen2191-13632020-08-019879780510.1002/open.202000126Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha TherapyFalco Reissig0Dr. Kristof Zarschler1Dr. René Hübner2Dr. Hans‐Jürgen Pietzsch3Prof. Dr. Klaus Kopka4Dr. Constantin Mamat5Institute of Radiopharmaceutical Cancer Research Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 400 01328 Dresden GermanyInstitute of Radiopharmaceutical Cancer Research Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 400 01328 Dresden GermanyInstitute of Ion Beam Physics and Materials Research Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 400 01328 Dresden GermanyInstitute of Radiopharmaceutical Cancer Research Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 400 01328 Dresden GermanyInstitute of Radiopharmaceutical Cancer Research Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 400 01328 Dresden GermanyInstitute of Radiopharmaceutical Cancer Research Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 400 01328 Dresden GermanyAbstract The treatment of cancer patients with α‐particle‐emitting therapeutics continues to gain in importance and relevance. The range of radiopharmaceutically relevant α‐emitters is limited to a few radionuclides, as stable chelators or carrier systems for safe transport of the radioactive cargo are often lacking. Encapsulation of α‐emitters into solid inorganic systems can help to diversify the portfolio of candidate radionuclides, provided, that these nanomaterials effectively retain both the parent and the recoil daughters. We therefore focus on designing stable and defined nanocarrier‐based systems for various clinically relevant radionuclides, including the promising α‐emitting radionuclide 224Ra. Hence, sub‐10 nm barium sulfate nanocontainers were prepared and different radiometals like 89Zr, 111In, 131Ba, 177Lu or 224Ra were incorporated. Our system shows stabilities of >90 % regarding the radiometal release from the BaSO4 matrix. Furthermore, we confirm the presence of surface‐exposed amine functionalities as well as the formation of a biomolecular corona.https://doi.org/10.1002/open.202000126radiolabelingradiumnanoencapsulationradiooncologybariumtherapeutic applications |
| spellingShingle | Falco Reissig Dr. Kristof Zarschler Dr. René Hübner Dr. Hans‐Jürgen Pietzsch Prof. Dr. Klaus Kopka Dr. Constantin Mamat Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy ChemistryOpen radiolabeling radium nanoencapsulation radiooncology barium therapeutic applications |
| title | Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy |
| title_full | Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy |
| title_fullStr | Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy |
| title_full_unstemmed | Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy |
| title_short | Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy |
| title_sort | sub 10 nm radiolabeled barium sulfate nanoparticles as carriers for theranostic applications and targeted alpha therapy |
| topic | radiolabeling radium nanoencapsulation radiooncology barium therapeutic applications |
| url | https://doi.org/10.1002/open.202000126 |
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