Transcriptomic studies of systemic lupus erythematosus
Abstract The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and treatment strategies for SLE, previous microarray and RNA sequencing studies have...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Inflammation and Regeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41232-021-00161-y |
| _version_ | 1818937435495596032 |
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| author | Masahiro Nakano Yukiko Iwasaki Keishi Fujio |
| author_facet | Masahiro Nakano Yukiko Iwasaki Keishi Fujio |
| author_sort | Masahiro Nakano |
| collection | DOAJ |
| description | Abstract The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and treatment strategies for SLE, previous microarray and RNA sequencing studies have demonstrated several disease-relevant signatures in SLE. Of these, the interferon (IFN) signature is complex, involving IFNβ- and IFNγ-response genes in addition to IFNα-response genes. Some studies revealed that myeloid lineage/neutrophil and plasma cell signatures as well as the IFN signature were correlated with disease activity, lupus nephritis, and complications of pregnancy, although some of these findings remain controversial. Cell-type-specific gene expression analysis revealed the importance of an exhaustion signature in CD8+ T cells for SLE outcome. Recent single-cell RNA sequencing analyses of SLE blood and tissues demonstrated molecular heterogeneity and identified several distinct subpopulations as key players in SLE pathogenesis. Further studies are required to identify novel treatment targets and determine precise patient stratification in SLE. In this review, we discuss the findings and limitations of SLE transcriptomic studies. |
| first_indexed | 2024-12-20T05:51:55Z |
| format | Article |
| id | doaj.art-438f401b2fdf4cf79fb2ab40ac0f7f7f |
| institution | Directory Open Access Journal |
| issn | 1880-8190 |
| language | English |
| last_indexed | 2024-12-20T05:51:55Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Inflammation and Regeneration |
| spelling | doaj.art-438f401b2fdf4cf79fb2ab40ac0f7f7f2022-12-21T19:51:08ZengBMCInflammation and Regeneration1880-81902021-04-014111810.1186/s41232-021-00161-yTranscriptomic studies of systemic lupus erythematosusMasahiro Nakano0Yukiko Iwasaki1Keishi Fujio2Department of Allergy and Rheumatology, Graduate School of Medicine, The University of TokyoDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of TokyoDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of TokyoAbstract The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and treatment strategies for SLE, previous microarray and RNA sequencing studies have demonstrated several disease-relevant signatures in SLE. Of these, the interferon (IFN) signature is complex, involving IFNβ- and IFNγ-response genes in addition to IFNα-response genes. Some studies revealed that myeloid lineage/neutrophil and plasma cell signatures as well as the IFN signature were correlated with disease activity, lupus nephritis, and complications of pregnancy, although some of these findings remain controversial. Cell-type-specific gene expression analysis revealed the importance of an exhaustion signature in CD8+ T cells for SLE outcome. Recent single-cell RNA sequencing analyses of SLE blood and tissues demonstrated molecular heterogeneity and identified several distinct subpopulations as key players in SLE pathogenesis. Further studies are required to identify novel treatment targets and determine precise patient stratification in SLE. In this review, we discuss the findings and limitations of SLE transcriptomic studies.https://doi.org/10.1186/s41232-021-00161-ySystemic lupus erythematosusLupus nephritisTranscriptomeReview |
| spellingShingle | Masahiro Nakano Yukiko Iwasaki Keishi Fujio Transcriptomic studies of systemic lupus erythematosus Inflammation and Regeneration Systemic lupus erythematosus Lupus nephritis Transcriptome Review |
| title | Transcriptomic studies of systemic lupus erythematosus |
| title_full | Transcriptomic studies of systemic lupus erythematosus |
| title_fullStr | Transcriptomic studies of systemic lupus erythematosus |
| title_full_unstemmed | Transcriptomic studies of systemic lupus erythematosus |
| title_short | Transcriptomic studies of systemic lupus erythematosus |
| title_sort | transcriptomic studies of systemic lupus erythematosus |
| topic | Systemic lupus erythematosus Lupus nephritis Transcriptome Review |
| url | https://doi.org/10.1186/s41232-021-00161-y |
| work_keys_str_mv | AT masahironakano transcriptomicstudiesofsystemiclupuserythematosus AT yukikoiwasaki transcriptomicstudiesofsystemiclupuserythematosus AT keishifujio transcriptomicstudiesofsystemiclupuserythematosus |