Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review
Several rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid art...
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MDPI AG
2023-10-01
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Online Access: | https://www.mdpi.com/2079-7737/12/10/1320 |
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author | Francesco Orsini Chiara Crotti Gilberto Cincinelli Raffaele Di Taranto Andrea Amati Matteo Ferrito Massimo Varenna Roberto Caporali |
author_facet | Francesco Orsini Chiara Crotti Gilberto Cincinelli Raffaele Di Taranto Andrea Amati Matteo Ferrito Massimo Varenna Roberto Caporali |
author_sort | Francesco Orsini |
collection | DOAJ |
description | Several rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Given the immunological and systemic nature of these diseases, in this review, we report an overview of the pathogenic mechanisms underlying specific bone involvement, focusing on the complex interactions that occur between bone tissue’s own cells and the molecular and cellular actors of the immune system, a recent and fascinating field of interest defined as osteoimmunology. Specifically, we comprehensively elaborate on the distinct pathogenic mechanisms of bone erosion seen in both rheumatoid arthritis and spondyloarthritis, as well as the characteristic process of aberrant bone formation observed in spondyloarthritis. Lastly, chronic inflammatory arthritis leads to systemic bone involvement, resulting in systemic bone loss and consequent osteoporosis, along with increased skeletal fragility. |
first_indexed | 2024-03-10T21:25:18Z |
format | Article |
id | doaj.art-438fa9afe9544aaebe2198359aa043e1 |
institution | Directory Open Access Journal |
issn | 2079-7737 |
language | English |
last_indexed | 2024-03-10T21:25:18Z |
publishDate | 2023-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Biology |
spelling | doaj.art-438fa9afe9544aaebe2198359aa043e12023-11-19T15:43:38ZengMDPI AGBiology2079-77372023-10-011210132010.3390/biology12101320Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated ReviewFrancesco Orsini0Chiara Crotti1Gilberto Cincinelli2Raffaele Di Taranto3Andrea Amati4Matteo Ferrito5Massimo Varenna6Roberto Caporali7Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyBone Diseases Unit, Department of Rheumatology and Medical Sciences, ASST G.Pini-CTO, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyBone Diseases Unit, Department of Rheumatology and Medical Sciences, ASST G.Pini-CTO, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalySeveral rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Given the immunological and systemic nature of these diseases, in this review, we report an overview of the pathogenic mechanisms underlying specific bone involvement, focusing on the complex interactions that occur between bone tissue’s own cells and the molecular and cellular actors of the immune system, a recent and fascinating field of interest defined as osteoimmunology. Specifically, we comprehensively elaborate on the distinct pathogenic mechanisms of bone erosion seen in both rheumatoid arthritis and spondyloarthritis, as well as the characteristic process of aberrant bone formation observed in spondyloarthritis. Lastly, chronic inflammatory arthritis leads to systemic bone involvement, resulting in systemic bone loss and consequent osteoporosis, along with increased skeletal fragility.https://www.mdpi.com/2079-7737/12/10/1320osteoimmunologyrheumatoid arthritiserosionsspondyloarthritisbone tissuenew bone formation |
spellingShingle | Francesco Orsini Chiara Crotti Gilberto Cincinelli Raffaele Di Taranto Andrea Amati Matteo Ferrito Massimo Varenna Roberto Caporali Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review Biology osteoimmunology rheumatoid arthritis erosions spondyloarthritis bone tissue new bone formation |
title | Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review |
title_full | Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review |
title_fullStr | Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review |
title_full_unstemmed | Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review |
title_short | Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review |
title_sort | bone involvement in rheumatoid arthritis and spondyloartritis an updated review |
topic | osteoimmunology rheumatoid arthritis erosions spondyloarthritis bone tissue new bone formation |
url | https://www.mdpi.com/2079-7737/12/10/1320 |
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