An overview of traditional Chinese medicine affecting gut microbiota in obesity
Obesity, a chronic metabolic disease with a complex pathophysiology, is caused by several variables. High-fat diets lead to the disruption of the gut microbiota and impaired gut barrier function in obese people. The dysbiosis and its metabolites through the intestinal barrier lead to an imbalance in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1149751/full |
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| author | Donghui Li Weiwei Tang Yanyan Wang Qi Gao Hongwei Zhang Yu Zhang Yuliang Wang Yongyi Yang Yingming Zhou Yike Zhang Haonan Li Shuo Li Hong Zhao |
| author_facet | Donghui Li Weiwei Tang Yanyan Wang Qi Gao Hongwei Zhang Yu Zhang Yuliang Wang Yongyi Yang Yingming Zhou Yike Zhang Haonan Li Shuo Li Hong Zhao |
| author_sort | Donghui Li |
| collection | DOAJ |
| description | Obesity, a chronic metabolic disease with a complex pathophysiology, is caused by several variables. High-fat diets lead to the disruption of the gut microbiota and impaired gut barrier function in obese people. The dysbiosis and its metabolites through the intestinal barrier lead to an imbalance in energy metabolism and inflammatory response, which eventually contributes to the development of chronic diseases such as diabetes, hypertension, and cardiovascular disease. Current medicines are therapeutic to obesity in the short term; however, they may bring significant physical and emotional problems to patients as major side effects. Therefore, it is urgent to explore new therapeutic methods that have definite efficacy, can be taken for a long time, and have mild adverse effects. Numerous studies have demonstrated that traditional Chinese medicine (TCM) can control the gut microbiota in a multi-targeted and comprehensive manner, thereby restoring flora homeostasis, repairing damaged intestinal mucosal barriers, and eventually curbing the development of obesity. The active ingredients and compounds of TCM can restore the normal physiological function of the intestinal mucosal barrier by regulating gut microbiota to regulate energy metabolism, inhibit fat accumulation, affect food appetite, and reduce intestinal mucosal inflammatory response, thereby effectively promoting weight loss and providing new strategies for obesity prevention and treatment. Although there are some studies on the regulation of gut microbiota by TCM to prevent and treat obesity, all of them have the disadvantage of being systematic and comprehensive. Therefore, this work comprehensively describes the molecular mechanism of obesity mediated by gut microbiota based on the research state of obesity, gut microbiota, and TCM. A comprehensive and systematic summary of TCM targeting the regulation of gut microbiota for the treatment of obesity should be conducted in order to provide new strategies and ideas for the treatment of obesity. |
| first_indexed | 2024-04-10T06:31:45Z |
| format | Article |
| id | doaj.art-4394b8bd3fea43cd8433f200cf45f63c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T06:31:45Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4394b8bd3fea43cd8433f200cf45f63c2023-03-01T06:50:49ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11497511149751An overview of traditional Chinese medicine affecting gut microbiota in obesityDonghui Li0Weiwei Tang1Yanyan Wang2Qi Gao3Hongwei Zhang4Yu Zhang5Yuliang Wang6Yongyi Yang7Yingming Zhou8Yike Zhang9Haonan Li10Shuo Li11Hong Zhao12College of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaDepartment of Emergency Surgery, The First Affiliated Hospital of Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, ChinaObesity, a chronic metabolic disease with a complex pathophysiology, is caused by several variables. High-fat diets lead to the disruption of the gut microbiota and impaired gut barrier function in obese people. The dysbiosis and its metabolites through the intestinal barrier lead to an imbalance in energy metabolism and inflammatory response, which eventually contributes to the development of chronic diseases such as diabetes, hypertension, and cardiovascular disease. Current medicines are therapeutic to obesity in the short term; however, they may bring significant physical and emotional problems to patients as major side effects. Therefore, it is urgent to explore new therapeutic methods that have definite efficacy, can be taken for a long time, and have mild adverse effects. Numerous studies have demonstrated that traditional Chinese medicine (TCM) can control the gut microbiota in a multi-targeted and comprehensive manner, thereby restoring flora homeostasis, repairing damaged intestinal mucosal barriers, and eventually curbing the development of obesity. The active ingredients and compounds of TCM can restore the normal physiological function of the intestinal mucosal barrier by regulating gut microbiota to regulate energy metabolism, inhibit fat accumulation, affect food appetite, and reduce intestinal mucosal inflammatory response, thereby effectively promoting weight loss and providing new strategies for obesity prevention and treatment. Although there are some studies on the regulation of gut microbiota by TCM to prevent and treat obesity, all of them have the disadvantage of being systematic and comprehensive. Therefore, this work comprehensively describes the molecular mechanism of obesity mediated by gut microbiota based on the research state of obesity, gut microbiota, and TCM. A comprehensive and systematic summary of TCM targeting the regulation of gut microbiota for the treatment of obesity should be conducted in order to provide new strategies and ideas for the treatment of obesity.https://www.frontiersin.org/articles/10.3389/fendo.2023.1149751/fulltraditional Chinese medicinegut microbiotaobesityshort-chain fatty acids (SCFAs)active ingredients |
| spellingShingle | Donghui Li Weiwei Tang Yanyan Wang Qi Gao Hongwei Zhang Yu Zhang Yuliang Wang Yongyi Yang Yingming Zhou Yike Zhang Haonan Li Shuo Li Hong Zhao An overview of traditional Chinese medicine affecting gut microbiota in obesity Frontiers in Endocrinology traditional Chinese medicine gut microbiota obesity short-chain fatty acids (SCFAs) active ingredients |
| title | An overview of traditional Chinese medicine affecting gut microbiota in obesity |
| title_full | An overview of traditional Chinese medicine affecting gut microbiota in obesity |
| title_fullStr | An overview of traditional Chinese medicine affecting gut microbiota in obesity |
| title_full_unstemmed | An overview of traditional Chinese medicine affecting gut microbiota in obesity |
| title_short | An overview of traditional Chinese medicine affecting gut microbiota in obesity |
| title_sort | overview of traditional chinese medicine affecting gut microbiota in obesity |
| topic | traditional Chinese medicine gut microbiota obesity short-chain fatty acids (SCFAs) active ingredients |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1149751/full |
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