Expansion of hematopoietic stem cells for transplantation: current perspectives
<p>Abstract</p> <p>Hematopoietic stem cells (HSCs) are rare cells that have the unique ability to self-renew and differentiate into cells of all hematopoietic lineages. The expansion of HSCs has remained an important goal to develop advanced cell therapies for bone marrow transplan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | http://www.ehoonline.org/content/1/1/12 |
| _version_ | 1818640565373239296 |
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| author | Schuster Jessica A Stupnikov Maria R Ma Gina Liao Wenbin Lai Raymond Ma Yupo Aguila Jerell R |
| author_facet | Schuster Jessica A Stupnikov Maria R Ma Gina Liao Wenbin Lai Raymond Ma Yupo Aguila Jerell R |
| author_sort | Schuster Jessica A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Hematopoietic stem cells (HSCs) are rare cells that have the unique ability to self-renew and differentiate into cells of all hematopoietic lineages. The expansion of HSCs has remained an important goal to develop advanced cell therapies for bone marrow transplantation and many blood disorders. Over the last several decades, there have been numerous attempts to expand HSCs in vitro using purified growth factors that are known to regulate HSCs. However, these attempts have been met with limited success for clinical applications. New developments in the HSC expansion field coupled with gene therapy and stem cell transplant should encourage progression in attractive treatment options for many disorders including hematologic conditions, immunodeficiencies, and genetic disorders.</p> |
| first_indexed | 2024-12-16T23:13:17Z |
| format | Article |
| id | doaj.art-4394ca0c390a4ea7a1f96596e0e6b027 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-16T23:13:17Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-4394ca0c390a4ea7a1f96596e0e6b0272022-12-21T22:12:22ZengBMCExperimental Hematology & Oncology2162-36192012-05-01111210.1186/2162-3619-1-12Expansion of hematopoietic stem cells for transplantation: current perspectivesSchuster Jessica AStupnikov Maria RMa GinaLiao WenbinLai RaymondMa YupoAguila Jerell R<p>Abstract</p> <p>Hematopoietic stem cells (HSCs) are rare cells that have the unique ability to self-renew and differentiate into cells of all hematopoietic lineages. The expansion of HSCs has remained an important goal to develop advanced cell therapies for bone marrow transplantation and many blood disorders. Over the last several decades, there have been numerous attempts to expand HSCs in vitro using purified growth factors that are known to regulate HSCs. However, these attempts have been met with limited success for clinical applications. New developments in the HSC expansion field coupled with gene therapy and stem cell transplant should encourage progression in attractive treatment options for many disorders including hematologic conditions, immunodeficiencies, and genetic disorders.</p>http://www.ehoonline.org/content/1/1/12Stem cell expansionGene therapyEpigeneticsUmbilical cord bloodHOXB4SALL4Notch signaling |
| spellingShingle | Schuster Jessica A Stupnikov Maria R Ma Gina Liao Wenbin Lai Raymond Ma Yupo Aguila Jerell R Expansion of hematopoietic stem cells for transplantation: current perspectives Experimental Hematology & Oncology Stem cell expansion Gene therapy Epigenetics Umbilical cord blood HOXB4 SALL4 Notch signaling |
| title | Expansion of hematopoietic stem cells for transplantation: current perspectives |
| title_full | Expansion of hematopoietic stem cells for transplantation: current perspectives |
| title_fullStr | Expansion of hematopoietic stem cells for transplantation: current perspectives |
| title_full_unstemmed | Expansion of hematopoietic stem cells for transplantation: current perspectives |
| title_short | Expansion of hematopoietic stem cells for transplantation: current perspectives |
| title_sort | expansion of hematopoietic stem cells for transplantation current perspectives |
| topic | Stem cell expansion Gene therapy Epigenetics Umbilical cord blood HOXB4 SALL4 Notch signaling |
| url | http://www.ehoonline.org/content/1/1/12 |
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