FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
Abstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα production was preserved at normal level. NO production by D...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/113 |
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| author | L. V. Sakhno O. Yu. Leplina Zh. M. Raspay M. A. Tikhonova E. V. Kurganova I. P. Gileva S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh |
| author_facet | L. V. Sakhno O. Yu. Leplina Zh. M. Raspay M. A. Tikhonova E. V. Kurganova I. P. Gileva S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh |
| author_sort | L. V. Sakhno |
| collection | DOAJ |
| description | Abstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα production was preserved at normal level. NO production by DCs from the patients was also reduced. In addition, it has been shown, that DCs of PT patients were characterized by low allostimulatory activity in mixed lymphocyte reaction (MLR), and this defect was more marked in the patients with PPD-anergy. As compared to healthy donors, DCs from the patients with PT (in particular, with PPD-anergy) exhibited a decreased capacity for induction of intracellular expression and production of IFNγ by T-cells. However, DCs from the patients with PPD-anergy were able to stimulate intracellular expression of IL-4 in CD3+T-cell subset. Hence, the results suggest that functional activity of DCs in the patients with PT is altered, and some of these changes are distinctly associated with decreased antigen-specific response. (Med. Immunol., 2008, vol. 10, N 2-3, pp 151-158). |
| first_indexed | 2024-03-08T05:51:28Z |
| format | Article |
| id | doaj.art-439743640c8e490cadd03ac88cadc002 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:20Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-439743640c8e490cadd03ac88cadc0022024-04-22T13:07:33ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01102-315115810.15789/1563-0625-2008-2-3-151-158110FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSISL. V. Sakhno0O. Yu. Leplina1Zh. M. Raspay2M. A. Tikhonova3E. V. Kurganova4I. P. Gileva5S. D. Nikonov6O. A. Zhdanov7A. A. Ostanin8E. R. Chernykh9ГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскОГУЗ Новосибирская клиническая туберкулезная больница № 1ОГУЗ Новосибирская клиническая туберкулезная больница № 1ОГУЗ Новосибирская клиническая туберкулезная больница № 1ГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскAbstract. Some functional properties of IFNα-induced dendritic cells (DCs) from the patients with pulmonary tuberculosis (PT) were under study. It was revealed that production of IFNγ and IFNα by DCs of the patients was decreased, but TNFα production was preserved at normal level. NO production by DCs from the patients was also reduced. In addition, it has been shown, that DCs of PT patients were characterized by low allostimulatory activity in mixed lymphocyte reaction (MLR), and this defect was more marked in the patients with PPD-anergy. As compared to healthy donors, DCs from the patients with PT (in particular, with PPD-anergy) exhibited a decreased capacity for induction of intracellular expression and production of IFNγ by T-cells. However, DCs from the patients with PPD-anergy were able to stimulate intracellular expression of IL-4 in CD3+T-cell subset. Hence, the results suggest that functional activity of DCs in the patients with PT is altered, and some of these changes are distinctly associated with decreased antigen-specific response. (Med. Immunol., 2008, vol. 10, N 2-3, pp 151-158).https://www.mimmun.ru/mimmun/article/view/113dendritic cellscytokinesth1/th2pulmonary tuberculosis |
| spellingShingle | L. V. Sakhno O. Yu. Leplina Zh. M. Raspay M. A. Tikhonova E. V. Kurganova I. P. Gileva S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS Медицинская иммунология dendritic cells cytokines th1/th2 pulmonary tuberculosis |
| title | FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full | FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_fullStr | FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full_unstemmed | FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_short | FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_sort | functional properties of ifnα induced dendritic cells in the patients with pulmonary tuberculosis |
| topic | dendritic cells cytokines th1/th2 pulmonary tuberculosis |
| url | https://www.mimmun.ru/mimmun/article/view/113 |
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