Temporal interference stimulation targets deep primate brain
Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains and whether the electric field produced under traditional sa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811924000764 |
| _version_ | 1797215948384501760 |
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| author | Ruobing Liu Guanyu Zhu Zhengping Wu Yifei Gan Jianguo Zhang Jiali Liu Liang Wang |
| author_facet | Ruobing Liu Guanyu Zhu Zhengping Wu Yifei Gan Jianguo Zhang Jiali Liu Liang Wang |
| author_sort | Ruobing Liu |
| collection | DOAJ |
| description | Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains and whether the electric field produced under traditional safety currents can penetrate deep regions as observed in mice. Despite recent model-based simulation studies offering positive evidence at both macro- and micro-scale levels, the absence of electrophysiological data from actual brains hinders comprehensive understanding and potential application of TI. This study aims to directly measure the spatiotemporal properties of the interfered electric field in the rhesus monkey brain and to validate the effects of TI on the human brain. Two monkeys were involved in the measurement, with implantation of several stereo-electroencephalography (SEEG) depth electrodes. TI stimulation was applied to anesthetized monkeys using two pairs of surface electrodes at differing stimulation parameters. Model-based simulations were also conducted and subsequently compared with actual recordings. Additionally, TI stimulation was administered to patients with motor disorders to validate its effects on motor symptoms.Through the integration of computational electric field simulation with empirical measurements, it was determined that the temporally interfering electric fields in the deep central regions are capable of attaining a magnitude sufficient to induce a subthreshold modulation effect on neural signals. Additionally, an improvement in movement disorders was observed as a result of TI stimulation. This study is the first to systematically measure the TI electric field in living non-human primates, offering empirical evidence that TI holds promise as a more focal and precise method for modulating neural activities in deep regions of a large brain. This advancement paves the way for future applications of TI in treating neuropsychiatric disorders. |
| first_indexed | 2024-04-24T11:38:10Z |
| format | Article |
| id | doaj.art-43975bfa51e9415d8a7dfce09fe081ae |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-24T11:38:10Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-43975bfa51e9415d8a7dfce09fe081ae2024-04-10T04:28:38ZengElsevierNeuroImage1095-95722024-05-01291120581Temporal interference stimulation targets deep primate brainRuobing Liu0Guanyu Zhu1Zhengping Wu2Yifei Gan3Jianguo Zhang4Jiali Liu5Liang Wang6CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR ChinaSchool of Innovations, Sanjiang University, Nanjing, PR ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China; Correspondence: CAS Key Lab of Mental Health, Institute of Psychology, 16 Lincui Rd., Chaoyang District, Beijing 100101, PR China.Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains and whether the electric field produced under traditional safety currents can penetrate deep regions as observed in mice. Despite recent model-based simulation studies offering positive evidence at both macro- and micro-scale levels, the absence of electrophysiological data from actual brains hinders comprehensive understanding and potential application of TI. This study aims to directly measure the spatiotemporal properties of the interfered electric field in the rhesus monkey brain and to validate the effects of TI on the human brain. Two monkeys were involved in the measurement, with implantation of several stereo-electroencephalography (SEEG) depth electrodes. TI stimulation was applied to anesthetized monkeys using two pairs of surface electrodes at differing stimulation parameters. Model-based simulations were also conducted and subsequently compared with actual recordings. Additionally, TI stimulation was administered to patients with motor disorders to validate its effects on motor symptoms.Through the integration of computational electric field simulation with empirical measurements, it was determined that the temporally interfering electric fields in the deep central regions are capable of attaining a magnitude sufficient to induce a subthreshold modulation effect on neural signals. Additionally, an improvement in movement disorders was observed as a result of TI stimulation. This study is the first to systematically measure the TI electric field in living non-human primates, offering empirical evidence that TI holds promise as a more focal and precise method for modulating neural activities in deep regions of a large brain. This advancement paves the way for future applications of TI in treating neuropsychiatric disorders.http://www.sciencedirect.com/science/article/pii/S1053811924000764Temporal interferenceDeep brain stimulationIntracranial eegmodel-based simulationelectric field |
| spellingShingle | Ruobing Liu Guanyu Zhu Zhengping Wu Yifei Gan Jianguo Zhang Jiali Liu Liang Wang Temporal interference stimulation targets deep primate brain NeuroImage Temporal interference Deep brain stimulation Intracranial eeg model-based simulation electric field |
| title | Temporal interference stimulation targets deep primate brain |
| title_full | Temporal interference stimulation targets deep primate brain |
| title_fullStr | Temporal interference stimulation targets deep primate brain |
| title_full_unstemmed | Temporal interference stimulation targets deep primate brain |
| title_short | Temporal interference stimulation targets deep primate brain |
| title_sort | temporal interference stimulation targets deep primate brain |
| topic | Temporal interference Deep brain stimulation Intracranial eeg model-based simulation electric field |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924000764 |
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