Anomeric Spironucleosides of β-<span style="font-variant: small-caps">d</span>-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase

Anomeric Spironucleosides of β-<span style="font-variant: small-caps">d</span>-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase

In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production by the liver. Anomeric spironucleosides, such as hydantocidin, present a rich synthetic chemistry...

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Bibliographic Details
Main Authors: Aggeliki Stathi, Michael Mamais, Evangelia D. Chrysina, Thanasis Gimisis
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
type 2 diabetes
glycogen phosphorylase
anomeric spironucleosides
1,6-dioxa-4-azaspiro[4.5]decane
[1,5]-radical translocation
Online Access:https://www.mdpi.com/1420-3049/24/12/2327

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