Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives

Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential io...

Full description

Bibliographic Details
Main Authors: Beatrice Oehler, Alexander Brack, Robert Blum, Heike L. Rittner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Endocrinology
Subjects:
oxidized phospholipids
TRP channel
ion channel
analgesia
pain therapy
nociception
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.613868/full

Similar Items

Similar Items