Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis. As pathway misregulation has been extensively linked to pathological processes including malignant tumors, a thorough und...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.631623/full |
| _version_ | 1818720023775019008 |
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| author | Yagmur Azbazdar Yagmur Azbazdar Mustafa Karabicici Mustafa Karabicici Esra Erdal Esra Erdal Gunes Ozhan Gunes Ozhan |
| author_facet | Yagmur Azbazdar Yagmur Azbazdar Mustafa Karabicici Mustafa Karabicici Esra Erdal Esra Erdal Gunes Ozhan Gunes Ozhan |
| author_sort | Yagmur Azbazdar |
| collection | DOAJ |
| description | Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis. As pathway misregulation has been extensively linked to pathological processes including malignant tumors, a thorough understanding of pathway regulation is essential for development of effective therapeutic approaches. A prominent feature of cancer cells is that they significantly differ from healthy cells with respect to their plasma membrane composition and lipid organization. Here, we review the key role of membrane composition and lipid order in activation of Wnt signaling pathway by tightly regulating formation and interactions of the Wnt-receptor complex. We also discuss in detail how plasma membrane components, in particular the ligands, (co)receptors and extracellular or membrane-bound modulators, of Wnt pathways are affected in lung, colorectal, liver and breast cancers that have been associated with abnormal activation of Wnt signaling. Wnt-receptor complex components and their modulators are frequently misexpressed in these cancers and this appears to correlate with metastasis and cancer progression. Thus, composition and organization of the plasma membrane can be exploited to develop new anticancer drugs that are targeted in a highly specific manner to the Wnt-receptor complex, rendering a more effective therapeutic outcome possible. |
| first_indexed | 2024-12-17T20:16:15Z |
| format | Article |
| id | doaj.art-439b81bb8ff14491bf325eb0905f2e99 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T20:16:15Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-439b81bb8ff14491bf325eb0905f2e992022-12-21T21:34:05ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01910.3389/fcell.2021.631623631623Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in CancerYagmur Azbazdar0Yagmur Azbazdar1Mustafa Karabicici2Mustafa Karabicici3Esra Erdal4Esra Erdal5Gunes Ozhan6Gunes Ozhan7Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, İzmir, TurkeyIzmir International Biomedicine and Genome Institute (IBG-Izmir), Dokuz Eylul University, İzmir, TurkeyIzmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, İzmir, TurkeyIzmir International Biomedicine and Genome Institute (IBG-Izmir), Dokuz Eylul University, İzmir, TurkeyIzmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, İzmir, TurkeyDepartment of Medical Biology and Genetics, Faculty of Medicine, Dokuz Eylul University, İzmir, TurkeyIzmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, İzmir, TurkeyIzmir International Biomedicine and Genome Institute (IBG-Izmir), Dokuz Eylul University, İzmir, TurkeyWnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis. As pathway misregulation has been extensively linked to pathological processes including malignant tumors, a thorough understanding of pathway regulation is essential for development of effective therapeutic approaches. A prominent feature of cancer cells is that they significantly differ from healthy cells with respect to their plasma membrane composition and lipid organization. Here, we review the key role of membrane composition and lipid order in activation of Wnt signaling pathway by tightly regulating formation and interactions of the Wnt-receptor complex. We also discuss in detail how plasma membrane components, in particular the ligands, (co)receptors and extracellular or membrane-bound modulators, of Wnt pathways are affected in lung, colorectal, liver and breast cancers that have been associated with abnormal activation of Wnt signaling. Wnt-receptor complex components and their modulators are frequently misexpressed in these cancers and this appears to correlate with metastasis and cancer progression. Thus, composition and organization of the plasma membrane can be exploited to develop new anticancer drugs that are targeted in a highly specific manner to the Wnt-receptor complex, rendering a more effective therapeutic outcome possible.https://www.frontiersin.org/articles/10.3389/fcell.2021.631623/fullWntfrizzledplasma membranecancerlipid raft |
| spellingShingle | Yagmur Azbazdar Yagmur Azbazdar Mustafa Karabicici Mustafa Karabicici Esra Erdal Esra Erdal Gunes Ozhan Gunes Ozhan Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer Frontiers in Cell and Developmental Biology Wnt frizzled plasma membrane cancer lipid raft |
| title | Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer |
| title_full | Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer |
| title_fullStr | Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer |
| title_full_unstemmed | Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer |
| title_short | Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer |
| title_sort | regulation of wnt signaling pathways at the plasma membrane and their misregulation in cancer |
| topic | Wnt frizzled plasma membrane cancer lipid raft |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.631623/full |
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