RUNX3: A Location-oriented Genome Coordinator
Transcription factors are key components in gene expression and are associated with various diseases. Transcription factors maintain the stability of gene transcription and cell function. Among the transcription factors, the Runt-related transcription factor (RUNX) family regulates growth and develo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2023-05-01
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| Series: | BIO Integration |
| Subjects: | |
| Online Access: | https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000001/art00005 |
| _version_ | 1797826681834045440 |
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| author | Tianshu Xu Yancan Liang Zhiquan Huang Zixian Huang |
| author_facet | Tianshu Xu Yancan Liang Zhiquan Huang Zixian Huang |
| author_sort | Tianshu Xu |
| collection | DOAJ |
| description | Transcription factors are key components in gene expression and are associated with various diseases. Transcription factors maintain the stability of gene transcription and cell function. Among the transcription factors, the Runt-related transcription factor (RUNX) family regulates growth and development in a tissue-specific manner and is involved in tumorigenesis. The function of an important member of the RUNX family, RUNX3, was shown to be closely related to its subcellular localization. Normally, RUNX3 promotes or represses gene transcription in the nucleus; however, when RUNX3 is restricted in the cytoplasm, RUNX3 fails to function and only has a minor effect o gene expression. Hence, the risk of tumorigenesis cannot simply be equated with the level of RUNX3 expression, which makes the diagnosis and treatment of cancer more complicated. The cytoplasmic localization of RUNX3 has been shown to be associated with a variety of tumors. Herein we have summarized the current information on RUNX3 mis-localization and RUNX3 promotion of tumorigenesis, thus providing new insight for future investigations to elucidate the mechanisms by which RUNX3 regulates tumorigenesis. |
| first_indexed | 2024-04-09T12:36:18Z |
| format | Article |
| id | doaj.art-439bb001be884536b54507363a1679d4 |
| institution | Directory Open Access Journal |
| issn | 2712-0082 |
| language | English |
| last_indexed | 2024-04-09T12:36:18Z |
| publishDate | 2023-05-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | BIO Integration |
| spelling | doaj.art-439bb001be884536b54507363a1679d42023-05-15T09:42:07ZengCompuscript LtdBIO Integration2712-00822023-05-0141303710.15212/bioi-2023-0003RUNX3: A Location-oriented Genome CoordinatorTianshu Xu0Yancan Liang1Zhiquan Huang2Zixian Huang3Department of Stomatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Stomatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th, Yanjiang Xi Road, Guangzhou, Guangdong, ChinaDepartment of Stomatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaTranscription factors are key components in gene expression and are associated with various diseases. Transcription factors maintain the stability of gene transcription and cell function. Among the transcription factors, the Runt-related transcription factor (RUNX) family regulates growth and development in a tissue-specific manner and is involved in tumorigenesis. The function of an important member of the RUNX family, RUNX3, was shown to be closely related to its subcellular localization. Normally, RUNX3 promotes or represses gene transcription in the nucleus; however, when RUNX3 is restricted in the cytoplasm, RUNX3 fails to function and only has a minor effect o gene expression. Hence, the risk of tumorigenesis cannot simply be equated with the level of RUNX3 expression, which makes the diagnosis and treatment of cancer more complicated. The cytoplasmic localization of RUNX3 has been shown to be associated with a variety of tumors. Herein we have summarized the current information on RUNX3 mis-localization and RUNX3 promotion of tumorigenesis, thus providing new insight for future investigations to elucidate the mechanisms by which RUNX3 regulates tumorigenesis.https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000001/art00005cytoplasmic localizationmis-localizationrunx3tumorigenesis |
| spellingShingle | Tianshu Xu Yancan Liang Zhiquan Huang Zixian Huang RUNX3: A Location-oriented Genome Coordinator BIO Integration cytoplasmic localization mis-localization runx3 tumorigenesis |
| title | RUNX3: A Location-oriented Genome Coordinator |
| title_full | RUNX3: A Location-oriented Genome Coordinator |
| title_fullStr | RUNX3: A Location-oriented Genome Coordinator |
| title_full_unstemmed | RUNX3: A Location-oriented Genome Coordinator |
| title_short | RUNX3: A Location-oriented Genome Coordinator |
| title_sort | runx3 a location oriented genome coordinator |
| topic | cytoplasmic localization mis-localization runx3 tumorigenesis |
| url | https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000001/art00005 |
| work_keys_str_mv | AT tianshuxu runx3alocationorientedgenomecoordinator AT yancanliang runx3alocationorientedgenomecoordinator AT zhiquanhuang runx3alocationorientedgenomecoordinator AT zixianhuang runx3alocationorientedgenomecoordinator |