Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review
Cancer is one of the leading causes of morbidity and mortality around the globe and is likely to become the major cause of global death in the coming years. As per World Health Organization (WHO) report, every year there are over 10 and 9 million new cases and deaths from this disease. Chemotherapy,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6608 |
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| author | Suhail Ahmad Mir Laraibah Hamid Ghulam Nabi Bader Ambreen Shoaib Mohamed Rahamathulla Mohammad Y. Alshahrani Prawez Alam Faiyaz Shakeel |
| author_facet | Suhail Ahmad Mir Laraibah Hamid Ghulam Nabi Bader Ambreen Shoaib Mohamed Rahamathulla Mohammad Y. Alshahrani Prawez Alam Faiyaz Shakeel |
| author_sort | Suhail Ahmad Mir |
| collection | DOAJ |
| description | Cancer is one of the leading causes of morbidity and mortality around the globe and is likely to become the major cause of global death in the coming years. As per World Health Organization (WHO) report, every year there are over 10 and 9 million new cases and deaths from this disease. Chemotherapy, radiotherapy, and surgery are the three basic approaches to treating cancer. These approaches are aiming at eradicating all cancer cells with minimum off-target effects on other cell types. Most drugs have serious adverse effects due to the lack of target selectivity. On the other hand, resistance to already available drugs has emerged as a major obstacle in cancer chemotherapy, allowing cancer to proliferate irrespective of the chemotherapeutic agent. Consequently, it leads to multidrug resistance (MDR), a growing concern in the scientific community. To overcome this problem, in recent years, nanotechnology-based drug therapies have been explored and have shown great promise in overcoming resistance, with most nano-based drugs being explored at the clinical level. Through this review, we try to explain various mechanisms involved in multidrug resistance in cancer and the role nanotechnology has played in overcoming or reversing this resistance. |
| first_indexed | 2024-03-09T21:23:33Z |
| format | Article |
| id | doaj.art-439c3d7984f44d4bbe775fb0a28a2f80 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:23:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-439c3d7984f44d4bbe775fb0a28a2f802023-11-23T21:14:14ZengMDPI AGMolecules1420-30492022-10-012719660810.3390/molecules27196608Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A ReviewSuhail Ahmad Mir0Laraibah Hamid1Ghulam Nabi Bader2Ambreen Shoaib3Mohamed Rahamathulla4Mohammad Y. Alshahrani5Prawez Alam6Faiyaz Shakeel7Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, IndiaDepartment of Zoology, University of Kashmir, Hazratbal, Srinagar 190006, IndiaDepartment of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, IndiaDepartment of Pharmacy Practice, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaCancer is one of the leading causes of morbidity and mortality around the globe and is likely to become the major cause of global death in the coming years. As per World Health Organization (WHO) report, every year there are over 10 and 9 million new cases and deaths from this disease. Chemotherapy, radiotherapy, and surgery are the three basic approaches to treating cancer. These approaches are aiming at eradicating all cancer cells with minimum off-target effects on other cell types. Most drugs have serious adverse effects due to the lack of target selectivity. On the other hand, resistance to already available drugs has emerged as a major obstacle in cancer chemotherapy, allowing cancer to proliferate irrespective of the chemotherapeutic agent. Consequently, it leads to multidrug resistance (MDR), a growing concern in the scientific community. To overcome this problem, in recent years, nanotechnology-based drug therapies have been explored and have shown great promise in overcoming resistance, with most nano-based drugs being explored at the clinical level. Through this review, we try to explain various mechanisms involved in multidrug resistance in cancer and the role nanotechnology has played in overcoming or reversing this resistance.https://www.mdpi.com/1420-3049/27/19/6608cancerchemotherapymultidrug resistancenanotechnologynanomedicine |
| spellingShingle | Suhail Ahmad Mir Laraibah Hamid Ghulam Nabi Bader Ambreen Shoaib Mohamed Rahamathulla Mohammad Y. Alshahrani Prawez Alam Faiyaz Shakeel Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review Molecules cancer chemotherapy multidrug resistance nanotechnology nanomedicine |
| title | Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review |
| title_full | Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review |
| title_fullStr | Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review |
| title_full_unstemmed | Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review |
| title_short | Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review |
| title_sort | role of nanotechnology in overcoming the multidrug resistance in cancer therapy a review |
| topic | cancer chemotherapy multidrug resistance nanotechnology nanomedicine |
| url | https://www.mdpi.com/1420-3049/27/19/6608 |
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