Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instabilit...

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Bibliographic Details
Main Authors: Federico Tommaso Bianchi, Chiara Tocco, Gianmarco Pallavicini, Yifan Liu, Fiammetta Vernì, Chiara Merigliano, Silvia Bonaccorsi, Nadia El-Assawy, Lorenzo Priano, Marta Gai, Gaia Elena Berto, Alessandra Maria Adelaide Chiotto, Francesco Sgrò, Alessia Caramello, Laura Tasca, Ugo Ala, Francesco Neri, Salvatore Oliviero, Alessandro Mauro, Stephan Geley, Maurizio Gatti, Ferdinando Di Cunto
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
citron kinase
microcephaly
genome instability
cytokinesis
DNA damage
double strand breaks
RAD51
apoptosis
TP53
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301110

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