| Summary: | Macromolecular engineering has benefited the fabrication of drug delivery systems, owing to the versatile and tunable physical and chemical properties of the polymeric carriers as needed. However, the slow excretion rate of the macromolecule carriers has raised safety concerns and discouraged the clinical application of drug delivery systems based on Macromolecular engineering. Recently in Matter, Q Qian et al. synthesized a PEG-based nanomedicine platform achieving fast excretion of drug carriers through degradation without losing the superiority of high-molecular-weight PEG. Therefore, the author provided a novel strategy to construct both safe and efficient drug delivery systems.
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