The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
Abstract Background The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lip...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01135-y |
| _version_ | 1811297541257428992 |
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| author | Worapaka Manosroi Pitchaporn Phudphong Pichitchai Atthakomol Mattabhorn Phimphilai |
| author_facet | Worapaka Manosroi Pitchaporn Phudphong Pichitchai Atthakomol Mattabhorn Phimphilai |
| author_sort | Worapaka Manosroi |
| collection | DOAJ |
| description | Abstract Background The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lipid profiles including triglyceride (TG), total cholesterol (TC), LDL and HDL levels in PA patients and EH patients. Methods A search of published studies was performed using PubMed, Embase and Scopus databases from their inception through August 2022. Thirty studies involving 11,175 patients were identified. Inclusion criteria included 1) observational studies which contained data on any of the lipid profiles of interest (TG, TC, LDL and HDL) which could be acquired from baseline data or the outcomes, 2) data which should be compared between adult PA and EH patients and 3) the use of appropriate methods to diagnose PA. Standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated to assess effect size by using STATA program version 15.0. Risk of bias was assessed by Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional, cohort and case-control studies. Results Levels of the lipid parameters TG (SMD − 0.16 mmol/L; 95%CI (− 0.25, − 0.07)), TC (SMD − 0.30 mmol/L; 95%CI (− 0.41, − 0.19)) and LDL (SMD − 0.17 mmol/L; 95%CI (− 0.27, − 0.08)) were significantly lower in PA than in EH patients. There was no statistically significant difference in HDL between PA and EH patients (SMD − 0.08 mmol/L; 96%CI (− 0.23,0.07)). High levels of heterogeneity for TG, TC, HDL and LDL were observed in all studies. Risk of bias among the studies was low to moderate. Conclusion Lower levels of TG, TC and LDL were observed in PA than in EH patients. Further study should be conducted to address the underlying mechanisms of lipid alteration in PA. |
| first_indexed | 2024-04-13T06:05:58Z |
| format | Article |
| id | doaj.art-43a039a4695349b7af469537a32d4256 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-13T06:05:58Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-43a039a4695349b7af469537a32d42562022-12-22T02:59:15ZengBMCBMC Endocrine Disorders1472-68232022-08-0122111410.1186/s12902-022-01135-yThe differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic reviewWorapaka Manosroi0Pitchaporn Phudphong1Pichitchai Atthakomol2Mattabhorn Phimphilai3Department of Internal Medicine, Faculty of Medicine, Chiang Mai UniversityDepartment of Internal Medicine, Faculty of Medicine, Chiang Mai UniversityOrthopaedics Department, Faculty of Medicine, Chiang Mai University, Muang Chiang MaiDepartment of Internal Medicine, Faculty of Medicine, Chiang Mai UniversityAbstract Background The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lipid profiles including triglyceride (TG), total cholesterol (TC), LDL and HDL levels in PA patients and EH patients. Methods A search of published studies was performed using PubMed, Embase and Scopus databases from their inception through August 2022. Thirty studies involving 11,175 patients were identified. Inclusion criteria included 1) observational studies which contained data on any of the lipid profiles of interest (TG, TC, LDL and HDL) which could be acquired from baseline data or the outcomes, 2) data which should be compared between adult PA and EH patients and 3) the use of appropriate methods to diagnose PA. Standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated to assess effect size by using STATA program version 15.0. Risk of bias was assessed by Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional, cohort and case-control studies. Results Levels of the lipid parameters TG (SMD − 0.16 mmol/L; 95%CI (− 0.25, − 0.07)), TC (SMD − 0.30 mmol/L; 95%CI (− 0.41, − 0.19)) and LDL (SMD − 0.17 mmol/L; 95%CI (− 0.27, − 0.08)) were significantly lower in PA than in EH patients. There was no statistically significant difference in HDL between PA and EH patients (SMD − 0.08 mmol/L; 96%CI (− 0.23,0.07)). High levels of heterogeneity for TG, TC, HDL and LDL were observed in all studies. Risk of bias among the studies was low to moderate. Conclusion Lower levels of TG, TC and LDL were observed in PA than in EH patients. Further study should be conducted to address the underlying mechanisms of lipid alteration in PA.https://doi.org/10.1186/s12902-022-01135-yPrimary aldosteronismEssential hypertensionLipid profilesTriglyceridesCholesterolHDL |
| spellingShingle | Worapaka Manosroi Pitchaporn Phudphong Pichitchai Atthakomol Mattabhorn Phimphilai The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review BMC Endocrine Disorders Primary aldosteronism Essential hypertension Lipid profiles Triglycerides Cholesterol HDL |
| title | The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review |
| title_full | The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review |
| title_fullStr | The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review |
| title_full_unstemmed | The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review |
| title_short | The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review |
| title_sort | differences of serum lipid profiles between primary aldosteronism and essential hypertension a meta analysis and systematic review |
| topic | Primary aldosteronism Essential hypertension Lipid profiles Triglycerides Cholesterol HDL |
| url | https://doi.org/10.1186/s12902-022-01135-y |
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