Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell
The global incidence of genital Chlamydia trachomatis infection increased rapidly as the primary available treatment of C. trachomatis infection being the use of antibiotics. However, the development of antibiotics resistant stain and other treatment failures are often observed in patients. Conseque...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002029/full |
| _version_ | 1798001331142656000 |
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| author | Xueying Yu Xueying Yu Qingqing Xu Wentao Chen Wentao Chen Zhida Mai Lijun Mo Xin Su Jiangli Ou Yinyuan Lan Heping Zheng Heping Zheng Yaohua Xue Yaohua Xue |
| author_facet | Xueying Yu Xueying Yu Qingqing Xu Wentao Chen Wentao Chen Zhida Mai Lijun Mo Xin Su Jiangli Ou Yinyuan Lan Heping Zheng Heping Zheng Yaohua Xue Yaohua Xue |
| author_sort | Xueying Yu |
| collection | DOAJ |
| description | The global incidence of genital Chlamydia trachomatis infection increased rapidly as the primary available treatment of C. trachomatis infection being the use of antibiotics. However, the development of antibiotics resistant stain and other treatment failures are often observed in patients. Consequently, novel therapeutics are urgently required. Rhein is a monomer derivative of anthraquinone compounds with an anti-infection activity. This study investigated the effects of rhein on treating C. trachomatis infection. Rhein showed significant inhibitory effects on the growth of C. trachomatis in multiple serovars of C. trachomatis, including D, E, F and L1, and in various host cells, including HeLa, McCoy and Vero. Rhein could not directly inactivate C. trachomatis but could inhibit the growth of C. trachomatis by regulating pathogen-host cell interactions. Combined with azithromycin, the inhibitory effect of rehin was synergistic both in vitro and in vivo. Together these findings suggest that rhein could be developed for the treatment of C. trachomatis infections. |
| first_indexed | 2024-04-11T11:34:24Z |
| format | Article |
| id | doaj.art-43a152df48984a758d5f5675a3c9e358 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T11:34:24Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-43a152df48984a758d5f5675a3c9e3582022-12-22T04:26:01ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-09-011010.3389/fpubh.2022.10020291002029Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cellXueying Yu0Xueying Yu1Qingqing Xu2Wentao Chen3Wentao Chen4Zhida Mai5Lijun Mo6Xin Su7Jiangli Ou8Yinyuan Lan9Heping Zheng10Heping Zheng11Yaohua Xue12Yaohua Xue13Department of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaGuangzhou Key Laboratory for Sexually Transmitted Diseases Control, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaGuangzhou Key Laboratory for Sexually Transmitted Diseases Control, Guangzhou, ChinaDepartment of Clinical Laboratory, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaGuangzhou Key Laboratory for Sexually Transmitted Diseases Control, Guangzhou, ChinaThe global incidence of genital Chlamydia trachomatis infection increased rapidly as the primary available treatment of C. trachomatis infection being the use of antibiotics. However, the development of antibiotics resistant stain and other treatment failures are often observed in patients. Consequently, novel therapeutics are urgently required. Rhein is a monomer derivative of anthraquinone compounds with an anti-infection activity. This study investigated the effects of rhein on treating C. trachomatis infection. Rhein showed significant inhibitory effects on the growth of C. trachomatis in multiple serovars of C. trachomatis, including D, E, F and L1, and in various host cells, including HeLa, McCoy and Vero. Rhein could not directly inactivate C. trachomatis but could inhibit the growth of C. trachomatis by regulating pathogen-host cell interactions. Combined with azithromycin, the inhibitory effect of rehin was synergistic both in vitro and in vivo. Together these findings suggest that rhein could be developed for the treatment of C. trachomatis infections.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002029/fullChlamydia trachomatisantibacterial activityrheinhost-directed therapyazithromycinin vivo |
| spellingShingle | Xueying Yu Xueying Yu Qingqing Xu Wentao Chen Wentao Chen Zhida Mai Lijun Mo Xin Su Jiangli Ou Yinyuan Lan Heping Zheng Heping Zheng Yaohua Xue Yaohua Xue Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell Frontiers in Public Health Chlamydia trachomatis antibacterial activity rhein host-directed therapy azithromycin in vivo |
| title | Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell |
| title_full | Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell |
| title_fullStr | Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell |
| title_full_unstemmed | Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell |
| title_short | Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell |
| title_sort | rhein inhibits chlamydia trachomatis infection by regulating pathogen host cell |
| topic | Chlamydia trachomatis antibacterial activity rhein host-directed therapy azithromycin in vivo |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002029/full |
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