Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study
Background: NIRSIT, a functional near-infrared spectroscopy (fNIRS) device with 204 channels, can measure oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in non-pulsatile blood flow non-invasively using the absorption difference between HbO2 and HbR at a wavelength of 700–1,000 nm and can display the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00898/full |
| _version_ | 1818840228551458816 |
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| author | Hyuksool Kwon Kyuseok Kim You Hwan Jo You Hwan Jo Min Ji Park Sang-Bae Ko Tae Jung Kim Jihoon Kang Hyeon-Min Bae Ji Eun Lee |
| author_facet | Hyuksool Kwon Kyuseok Kim You Hwan Jo You Hwan Jo Min Ji Park Sang-Bae Ko Tae Jung Kim Jihoon Kang Hyeon-Min Bae Ji Eun Lee |
| author_sort | Hyuksool Kwon |
| collection | DOAJ |
| description | Background: NIRSIT, a functional near-infrared spectroscopy (fNIRS) device with 204 channels, can measure oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in non-pulsatile blood flow non-invasively using the absorption difference between HbO2 and HbR at a wavelength of 700–1,000 nm and can display the perfusion status in real time.Objective: We applied NIRSIT to patients with stroke to evaluate the usefulness of NIRSIT as an fNIRS device for the early detection of stroke.Methods: We performed a prospective pilot study in an emergency department (ED). Adult patients who had suspected symptoms and signs of stroke within 12 h of the first abnormal time and who underwent intravenous thrombolysis (IVT) or intra-arterial thrombectomy with acute middle cerebral artery (MCA) or internal carotid artery (ICA) infarction were enrolled. NIRSIT was applied to the patients before the imaging study, and the perfusion status of the brain was displayed in real time at the bedside. We compared the NIRSIT results with the mean transit time (MTT) map from perfusion computed tomography (PCT) and the time-to-peak (TTP) map from perfusion-weighted magnetic resonance imaging (PWI).Results: Six male and three female patients were enrolled, and the median age was 74 years. The most common symptom was unilateral extremity weakness (77.8%), followed by dysarthria (33.3%) and aphasia (11.1%). The median National Institutes of Health Stroke Scale (NIHSS) score was 17. All cases of MCA infarction showed different cerebral oxygen saturation values between bilateral lobes of the brain in fNIRS imaging, and these values matched the PCT and PWI results.Conclusions: The brain hemisphere with low oxygen saturation on fNIRS showed hypoperfusion on PCT or PWI. The fNIRS device could be useful in assessing the perfusion status of the brain and detecting MCA or ICA infarction in real time at the bedside. |
| first_indexed | 2024-12-19T04:06:51Z |
| format | Article |
| id | doaj.art-43a1eb4a2df34466aef6ab505a911d58 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T04:06:51Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-43a1eb4a2df34466aef6ab505a911d582022-12-21T20:36:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-11-01910.3389/fneur.2018.00898400183Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot StudyHyuksool Kwon0Kyuseok Kim1You Hwan Jo2You Hwan Jo3Min Ji Park4Sang-Bae Ko5Tae Jung Kim6Jihoon Kang7Hyeon-Min Bae8Ji Eun Lee9Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, South KoreaDepartment of Emergency Medicine, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, South KoreaDepartment of Emergency Medicine, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Emergency Medicine, Mediplex Sejong Hospital, Incheon, South KoreaDepartment of Neurology, Seoul National University Hospital, Seoul, South KoreaDepartment of Neurology, Seoul National University Hospital, Seoul, South KoreaDepartment of Neurology, Seoul National University Bundang Hospital, Sungnam-si, South KoreaDepartment of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South KoreaDepartment of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, South KoreaBackground: NIRSIT, a functional near-infrared spectroscopy (fNIRS) device with 204 channels, can measure oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in non-pulsatile blood flow non-invasively using the absorption difference between HbO2 and HbR at a wavelength of 700–1,000 nm and can display the perfusion status in real time.Objective: We applied NIRSIT to patients with stroke to evaluate the usefulness of NIRSIT as an fNIRS device for the early detection of stroke.Methods: We performed a prospective pilot study in an emergency department (ED). Adult patients who had suspected symptoms and signs of stroke within 12 h of the first abnormal time and who underwent intravenous thrombolysis (IVT) or intra-arterial thrombectomy with acute middle cerebral artery (MCA) or internal carotid artery (ICA) infarction were enrolled. NIRSIT was applied to the patients before the imaging study, and the perfusion status of the brain was displayed in real time at the bedside. We compared the NIRSIT results with the mean transit time (MTT) map from perfusion computed tomography (PCT) and the time-to-peak (TTP) map from perfusion-weighted magnetic resonance imaging (PWI).Results: Six male and three female patients were enrolled, and the median age was 74 years. The most common symptom was unilateral extremity weakness (77.8%), followed by dysarthria (33.3%) and aphasia (11.1%). The median National Institutes of Health Stroke Scale (NIHSS) score was 17. All cases of MCA infarction showed different cerebral oxygen saturation values between bilateral lobes of the brain in fNIRS imaging, and these values matched the PCT and PWI results.Conclusions: The brain hemisphere with low oxygen saturation on fNIRS showed hypoperfusion on PCT or PWI. The fNIRS device could be useful in assessing the perfusion status of the brain and detecting MCA or ICA infarction in real time at the bedside.https://www.frontiersin.org/article/10.3389/fneur.2018.00898/fullcerebral infarctionperfusionmiddle cerebral arterycomputed tomographymagnetic resonance imaging |
| spellingShingle | Hyuksool Kwon Kyuseok Kim You Hwan Jo You Hwan Jo Min Ji Park Sang-Bae Ko Tae Jung Kim Jihoon Kang Hyeon-Min Bae Ji Eun Lee Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study Frontiers in Neurology cerebral infarction perfusion middle cerebral artery computed tomography magnetic resonance imaging |
| title | Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study |
| title_full | Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study |
| title_fullStr | Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study |
| title_full_unstemmed | Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study |
| title_short | Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study |
| title_sort | early detection of cerebral infarction with middle cerebral artery occlusion with functional near infrared spectroscopy a pilot study |
| topic | cerebral infarction perfusion middle cerebral artery computed tomography magnetic resonance imaging |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00898/full |
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