Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse
Diabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species (ROS) production, leading to deleterious complications, such as nephropathy, atherosclerosis and cardiac dysfunction, and target major organs in the body. The aim of this study was to investigate the effect of ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/11/3262 |
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| author | Nada Oršolić Damir Sirovina Dyana Odeh Goran Gajski Vedran Balta Lidija Šver Maja Jazvinšćak Jembrek |
| author_facet | Nada Oršolić Damir Sirovina Dyana Odeh Goran Gajski Vedran Balta Lidija Šver Maja Jazvinšćak Jembrek |
| author_sort | Nada Oršolić |
| collection | DOAJ |
| description | Diabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species (ROS) production, leading to deleterious complications, such as nephropathy, atherosclerosis and cardiac dysfunction, and target major organs in the body. The aim of this study was to investigate the effect of caffeic acid (CA) on mouse weight and survival, serum level of fasting blood glucose (FBG), serum lipid parameters and atherogenic indices, oxidative damage in blood, liver and kidney tissue, pathophysiological changes and their function markers in healthy and alloxan-induced type 1 diabetic mice. Diabetes was induced in mice with a single intravenous injection of alloxan (75 mg kg<sup>−1</sup>). Two days later, CA (50 mg kg<sup>−1</sup>) was given intraperitoneally for seven days in diabetic mice. Diabetes affected glucose level, lipid profile, hematological and biochemical parameters, induced DNA damage and apoptotic/necrotic death in whole blood cells, liver and kidney, leading to weight loss and a decreased lifespan. CA treatment of diabetic mice revealed a protective effect on the liver and kidney, hypoglycemic and hypolipidemic properties and high protection against atherogenic outcomes. The obtained results suggest that CA is a safe and potent agent against diabetes that acts as an effective antioxidant in reducing serum glucose, lipid profile and atherogenic indices, leading to increased lifespan in mice. |
| first_indexed | 2024-03-10T10:55:27Z |
| format | Article |
| id | doaj.art-43a39eeee498401188cd9b57553aa27f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:55:27Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-43a39eeee498401188cd9b57553aa27f2023-11-21T21:52:50ZengMDPI AGMolecules1420-30492021-05-012611326210.3390/molecules26113262Efficacy of Caffeic Acid on Diabetes and Its Complications in the MouseNada Oršolić0Damir Sirovina1Dyana Odeh2Goran Gajski3Vedran Balta4Lidija Šver5Maja Jazvinšćak Jembrek6Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, CroatiaDepartment of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, CroatiaDepartment of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, CroatiaMutagenesis Unit, Institute for Medical Research and Occupational Health, HR-10000 Zagreb, CroatiaDepartment of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, CroatiaDepartment of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, CroatiaLaboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10 000 Zagreb, CroatiaDiabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species (ROS) production, leading to deleterious complications, such as nephropathy, atherosclerosis and cardiac dysfunction, and target major organs in the body. The aim of this study was to investigate the effect of caffeic acid (CA) on mouse weight and survival, serum level of fasting blood glucose (FBG), serum lipid parameters and atherogenic indices, oxidative damage in blood, liver and kidney tissue, pathophysiological changes and their function markers in healthy and alloxan-induced type 1 diabetic mice. Diabetes was induced in mice with a single intravenous injection of alloxan (75 mg kg<sup>−1</sup>). Two days later, CA (50 mg kg<sup>−1</sup>) was given intraperitoneally for seven days in diabetic mice. Diabetes affected glucose level, lipid profile, hematological and biochemical parameters, induced DNA damage and apoptotic/necrotic death in whole blood cells, liver and kidney, leading to weight loss and a decreased lifespan. CA treatment of diabetic mice revealed a protective effect on the liver and kidney, hypoglycemic and hypolipidemic properties and high protection against atherogenic outcomes. The obtained results suggest that CA is a safe and potent agent against diabetes that acts as an effective antioxidant in reducing serum glucose, lipid profile and atherogenic indices, leading to increased lifespan in mice.https://www.mdpi.com/1420-3049/26/11/3262alloxandiabetesmicecaffeic acidbloodliver and kidney damage |
| spellingShingle | Nada Oršolić Damir Sirovina Dyana Odeh Goran Gajski Vedran Balta Lidija Šver Maja Jazvinšćak Jembrek Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse Molecules alloxan diabetes mice caffeic acid blood liver and kidney damage |
| title | Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse |
| title_full | Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse |
| title_fullStr | Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse |
| title_full_unstemmed | Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse |
| title_short | Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse |
| title_sort | efficacy of caffeic acid on diabetes and its complications in the mouse |
| topic | alloxan diabetes mice caffeic acid blood liver and kidney damage |
| url | https://www.mdpi.com/1420-3049/26/11/3262 |
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