Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline
Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289524000018 |
| _version_ | 1827315536911925248 |
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| author | Laurel R. Seemiller Julio Flores-Cuadra Keith R. Griffith Grace C. Smith Nicole A. Crowley |
| author_facet | Laurel R. Seemiller Julio Flores-Cuadra Keith R. Griffith Grace C. Smith Nicole A. Crowley |
| author_sort | Laurel R. Seemiller |
| collection | DOAJ |
| description | Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD. |
| first_indexed | 2024-03-08T16:09:13Z |
| format | Article |
| id | doaj.art-43a5e825c5644f3baa23628192eac7df |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-04-24T22:56:56Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-43a5e825c5644f3baa23628192eac7df2024-03-18T04:33:59ZengElsevierNeurobiology of Stress2352-28952024-03-0129100605Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive declineLaurel R. Seemiller0Julio Flores-Cuadra1Keith R. Griffith2Grace C. Smith3Nicole A. Crowley4Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park, PA, 16802, USADepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA; Neuroscience Graduate Program, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USADepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USADepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USADepartment of Biology, The Pennsylvania State University, University Park, PA, 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; Neuroscience Graduate Program, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; Corresponding author. 326 Mueller Lab, Penn State University, University Park, PA, 16802, USA.Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.http://www.sciencedirect.com/science/article/pii/S2352289524000018Alzheimer's DiseaseStressAlcoholNeurodegenerationCognitive declineLifespan |
| spellingShingle | Laurel R. Seemiller Julio Flores-Cuadra Keith R. Griffith Grace C. Smith Nicole A. Crowley Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline Neurobiology of Stress Alzheimer's Disease Stress Alcohol Neurodegeneration Cognitive decline Lifespan |
| title | Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline |
| title_full | Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline |
| title_fullStr | Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline |
| title_full_unstemmed | Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline |
| title_short | Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline |
| title_sort | alcohol and stress exposure across the lifespan are key risk factors for alzheimer s disease and cognitive decline |
| topic | Alzheimer's Disease Stress Alcohol Neurodegeneration Cognitive decline Lifespan |
| url | http://www.sciencedirect.com/science/article/pii/S2352289524000018 |
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