Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity
Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, inclu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1175575/full |
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| author | Azat Nasretdinov Sebastian A. Barrientos Sebastian A. Barrientos Ivani Brys Ivani Brys Ivani Brys Pär Halje Per Petersson Per Petersson |
| author_facet | Azat Nasretdinov Sebastian A. Barrientos Sebastian A. Barrientos Ivani Brys Ivani Brys Ivani Brys Pär Halje Per Petersson Per Petersson |
| author_sort | Azat Nasretdinov |
| collection | DOAJ |
| description | Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connectivity between various brain nodes. In addition, animal studies using invasive recordings, have suggested synchronous high-frequency oscillations involving several brain regions as another key feature of the psychedelic brain state. To better understand how the imaging data might be related to high-resolution electrophysiological measurements, we have here analyzed the aperiodic part of the local field potential (LFP) in rodents treated with a classic psychedelic (LSD) or a dissociative anesthetic (ketamine). In addition, functional connectivity, as quantified by mutual information measures in the LFP time series, has been assessed with in and between different structures. Our data suggest that the altered brain states of LSD and ketamine are caused by different underlying mechanisms, where LFP power shifts indicate increased neuronal activity but reduced connectivity following ketamine, while LSD also leads to reduced connectivity but without an accompanying change in LFP broadband power. |
| first_indexed | 2024-03-13T10:02:02Z |
| format | Article |
| id | doaj.art-43a61b3429744034be934ddd31a09de6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T10:02:02Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-43a61b3429744034be934ddd31a09de62023-05-23T05:00:38ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-05-011710.3389/fnins.2023.11755751175575Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivityAzat Nasretdinov0Sebastian A. Barrientos1Sebastian A. Barrientos2Ivani Brys3Ivani Brys4Ivani Brys5Pär Halje6Per Petersson7Per Petersson8The Group for Integrative Neurophysiology, Department of Integrative Medical Biology, Umeå University, Umeå, SwedenThe Group for Integrative Neurophysiology, Department of Integrative Medical Biology, Umeå University, Umeå, SwedenThe Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, SwedenThe Group for Integrative Neurophysiology, Department of Integrative Medical Biology, Umeå University, Umeå, SwedenThe Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, SwedenPostgraduate Program in Psychology, Health, and Biological Sciences, Federal University of Vale do São Francisco (UNIVASF), Petrolina, BrazilThe Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, SwedenThe Group for Integrative Neurophysiology, Department of Integrative Medical Biology, Umeå University, Umeå, SwedenThe Group for Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Science, Lund University, Lund, SwedenPsychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connectivity between various brain nodes. In addition, animal studies using invasive recordings, have suggested synchronous high-frequency oscillations involving several brain regions as another key feature of the psychedelic brain state. To better understand how the imaging data might be related to high-resolution electrophysiological measurements, we have here analyzed the aperiodic part of the local field potential (LFP) in rodents treated with a classic psychedelic (LSD) or a dissociative anesthetic (ketamine). In addition, functional connectivity, as quantified by mutual information measures in the LFP time series, has been assessed with in and between different structures. Our data suggest that the altered brain states of LSD and ketamine are caused by different underlying mechanisms, where LFP power shifts indicate increased neuronal activity but reduced connectivity following ketamine, while LSD also leads to reduced connectivity but without an accompanying change in LFP broadband power.https://www.frontiersin.org/articles/10.3389/fnins.2023.1175575/fullpsychedelicsdissociative anestheticsin vivoneurophysiologyLFP |
| spellingShingle | Azat Nasretdinov Sebastian A. Barrientos Sebastian A. Barrientos Ivani Brys Ivani Brys Ivani Brys Pär Halje Per Petersson Per Petersson Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity Frontiers in Neuroscience psychedelics dissociative anesthetics in vivo neurophysiology LFP |
| title | Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity |
| title_full | Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity |
| title_fullStr | Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity |
| title_full_unstemmed | Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity |
| title_short | Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity |
| title_sort | systems level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity |
| topic | psychedelics dissociative anesthetics in vivo neurophysiology LFP |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1175575/full |
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