GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder
Background Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. Aims To simultaneously examine effects...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2016-09-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472400001757/type/journal_article |
| _version_ | 1811157076387299328 |
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| author | Chih-Ken Chen Chau-Shoun Lee Hsuan-Yu Chen Lawrence Shih-Hsin Wu Jung-Chen Chang Chia-Yih Liu Andrew Tai-Ann Cheng |
| author_facet | Chih-Ken Chen Chau-Shoun Lee Hsuan-Yu Chen Lawrence Shih-Hsin Wu Jung-Chen Chang Chia-Yih Liu Andrew Tai-Ann Cheng |
| author_sort | Chih-Ken Chen |
| collection | DOAJ |
| description |
Background
Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders.
Aims
To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder.
Method
Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n = 215).
Results
GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence.
Conclusions
GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients.
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| first_indexed | 2024-04-10T05:01:13Z |
| format | Article |
| id | doaj.art-43a630c5ea484e42b0431a8c510289c4 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:01:13Z |
| publishDate | 2016-09-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-43a630c5ea484e42b0431a8c510289c42023-03-09T12:28:39ZengCambridge University PressBJPsych Open2056-47242016-09-01230130610.1192/bjpo.bp.116.002881GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorderChih-Ken Chen0Chau-Shoun Lee1Hsuan-Yu Chen2Lawrence Shih-Hsin Wu3Jung-Chen Chang4Chia-Yih Liu5Andrew Tai-Ann Cheng6Chang Gung University School of Medicine, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, TaiwanDepartment of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Psychiatry, Mackay Memorial Hospital, Taipei, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei, TaiwanInstitute of Medical Sciences, Tzu Chi University, Hualien, TaiwanSchool of Nursing, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, Chang Gung Medical Center at Linkou, Chang Gung University, Taoyuan, Taiwan; Chang Gung University School of Medicine, Taoyuan, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Background Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. Aims To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. Method Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n = 215). Results GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence. Conclusions GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients. https://www.cambridge.org/core/product/identifier/S2056472400001757/type/journal_article |
| spellingShingle | Chih-Ken Chen Chau-Shoun Lee Hsuan-Yu Chen Lawrence Shih-Hsin Wu Jung-Chen Chang Chia-Yih Liu Andrew Tai-Ann Cheng GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder BJPsych Open |
| title | GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder |
| title_full | GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder |
| title_fullStr | GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder |
| title_full_unstemmed | GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder |
| title_short | GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder |
| title_sort | gadl1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar i disorder |
| url | https://www.cambridge.org/core/product/identifier/S2056472400001757/type/journal_article |
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