Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach.
Airway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung. These diseases are associated with the dysregulation of multiple molecular pat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4076832?pdf=render |
| _version_ | 1819075417526501376 |
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| author | Ali Najafi Ali Najafi Ali Masoudi-Nejad Mostafa Ghanei Mohamad-Reza Nourani Ali Moeini |
| author_facet | Ali Najafi Ali Najafi Ali Masoudi-Nejad Mostafa Ghanei Mohamad-Reza Nourani Ali Moeini |
| author_sort | Ali Najafi |
| collection | DOAJ |
| description | Airway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung. These diseases are associated with the dysregulation of multiple molecular pathways in the airway cells. Little progress has so far been made in discovering the molecular causes of complex disease in a holistic systems manner. Therefore, pathway and network reconstruction is an essential part of a systems biology approach to solve this challenging problem. In this paper, multiple data sources were used to construct the molecular process of airway remodeling pathway in mustard lung as a model of airway disease. We first compiled a master list of genes that change with airway remodeling in the mustard lung disease and then reconstructed the pathway by generating and merging the protein-protein interaction and the gene regulatory networks. Experimental observations and literature mining were used to identify and validate the master list. The outcome of this paper can provide valuable information about closely related chronic obstructive airway diseases which are of great importance for biologists and their future research. Reconstructing the airway remodeling interactome provides a starting point and reference for the future experimental study of mustard lung, and further analysis and development of these maps will be critical to understanding airway diseases in patients. |
| first_indexed | 2024-12-21T18:25:05Z |
| format | Article |
| id | doaj.art-43a77debca034cdf82b2474b0a4e88c8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T18:25:05Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-43a77debca034cdf82b2474b0a4e88c82022-12-21T18:54:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e10009410.1371/journal.pone.0100094Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach.Ali NajafiAli NajafiAli Masoudi-NejadMostafa GhaneiMohamad-Reza NouraniAli MoeiniAirway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung. These diseases are associated with the dysregulation of multiple molecular pathways in the airway cells. Little progress has so far been made in discovering the molecular causes of complex disease in a holistic systems manner. Therefore, pathway and network reconstruction is an essential part of a systems biology approach to solve this challenging problem. In this paper, multiple data sources were used to construct the molecular process of airway remodeling pathway in mustard lung as a model of airway disease. We first compiled a master list of genes that change with airway remodeling in the mustard lung disease and then reconstructed the pathway by generating and merging the protein-protein interaction and the gene regulatory networks. Experimental observations and literature mining were used to identify and validate the master list. The outcome of this paper can provide valuable information about closely related chronic obstructive airway diseases which are of great importance for biologists and their future research. Reconstructing the airway remodeling interactome provides a starting point and reference for the future experimental study of mustard lung, and further analysis and development of these maps will be critical to understanding airway diseases in patients.http://europepmc.org/articles/PMC4076832?pdf=render |
| spellingShingle | Ali Najafi Ali Najafi Ali Masoudi-Nejad Mostafa Ghanei Mohamad-Reza Nourani Ali Moeini Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. PLoS ONE |
| title | Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. |
| title_full | Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. |
| title_fullStr | Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. |
| title_full_unstemmed | Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. |
| title_short | Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. |
| title_sort | pathway reconstruction of airway remodeling in chronic lung diseases a systems biology approach |
| url | http://europepmc.org/articles/PMC4076832?pdf=render |
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