Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module

Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module

IntroductionObscurin (720–870 kDa) is a giant cytoskeletal and signaling protein that possesses both structural and regulatory functions in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin bind to a diverse set of proteins that are essential for the proper structure and function...

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Bibliographic Details
Main Authors: Alyssa Grogan, Weiliang Huang, Annie Brong, Maureen A. Kane, Aikaterini Kontrogianni-Konstantopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
obscurin
atrial fibrillation
arrhythmia
Z-disk
Ca2+ cycling
cytoskeleton
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1085840/full

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