Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study
ABSTRACT Objective: To describe clinical characteristics, resource use, outcomes, and to identify predictors of in-hospital mortality of patients with COVID-19 admitted to the intensive care unit. Methods: Retrospective single-center cohort study conducted at a private hospital in São Paulo (SP),...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2021-12-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100251&tlng=pt |
| _version_ | 1798021568235831296 |
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| author | Thiago Domingos Corrêa Thais Dias Midega Karina Tavares Timenetsky Ricardo Luiz Cordioli Carmen Silvia Valente Barbas Moacyr Silva Júnior Bruno de Arruda Bravim Bruno Caldin Silva Gustavo Faissol Janot de Matos Ricardo Kenji Nawa Fabrício Rodrigues Torres de Carvalho Verônica Neves Fialho Queiroz Roberto Rabello Filho Felipe Maia de Toledo Piza Adriano José Pereira Marcele Liliane Pesavento Raquel Afonso Caserta Eid Bento Fortunato Cardoso dos Santos Andreia Pardini Vanessa Damázio Teich Claudia Regina Laselva Miguel Cendoroglo Neto Sidney Klajner Leonardo José Rolim Ferraz |
| author_facet | Thiago Domingos Corrêa Thais Dias Midega Karina Tavares Timenetsky Ricardo Luiz Cordioli Carmen Silvia Valente Barbas Moacyr Silva Júnior Bruno de Arruda Bravim Bruno Caldin Silva Gustavo Faissol Janot de Matos Ricardo Kenji Nawa Fabrício Rodrigues Torres de Carvalho Verônica Neves Fialho Queiroz Roberto Rabello Filho Felipe Maia de Toledo Piza Adriano José Pereira Marcele Liliane Pesavento Raquel Afonso Caserta Eid Bento Fortunato Cardoso dos Santos Andreia Pardini Vanessa Damázio Teich Claudia Regina Laselva Miguel Cendoroglo Neto Sidney Klajner Leonardo José Rolim Ferraz |
| author_sort | Thiago Domingos Corrêa |
| collection | DOAJ |
| description | ABSTRACT Objective: To describe clinical characteristics, resource use, outcomes, and to identify predictors of in-hospital mortality of patients with COVID-19 admitted to the intensive care unit. Methods: Retrospective single-center cohort study conducted at a private hospital in São Paulo (SP), Brazil. All consecutive adult (≥18 years) patients admitted to the intensive care unit, between March 4, 2020 and February 28, 2021 were included in this study. Patients were categorized between survivors and non-survivors according to hospital discharge. Results: During the study period, 1,296 patients [median (interquartile range) age: 66 (53-77) years] with COVID-19 were admitted to the intensive care unit. Out of those, 170 (13.6%) died at hospital (non-survivors) and 1,078 (86.4%) were discharged (survivors). Compared to survivors, non-survivors were older [80 (70-88) versus 63 (50-74) years; p<0.001], had a higher Simplified Acute Physiology Score 3 [59 (54-66) versus 47 (42-53) points; p<0.001], and presented comorbidities more frequently. During the intensive care unit stay, 56.6% of patients received noninvasive ventilation, 32.9% received mechanical ventilation, 31.3% used high flow nasal cannula, 11.7% received renal replacement therapy, and 1.5% used extracorporeal membrane oxygenation. Independent predictors of in-hospital mortality included age, Sequential Organ Failure Assessment score, Charlson Comorbidity Index, need for mechanical ventilation, high flow nasal cannula, renal replacement therapy, and extracorporeal membrane oxygenation support. Conclusion: Patients with severe COVID-19 admitted to the intensive care unit exhibited a considerable morbidity and mortality, demanding substantial organ support, and prolonged intensive care unit and hospital stay. |
| first_indexed | 2024-04-11T17:15:40Z |
| format | Article |
| id | doaj.art-43a85a62117445799ca9397f2db6f434 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-11T17:15:40Z |
| publishDate | 2021-12-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-43a85a62117445799ca9397f2db6f4342022-12-22T04:12:40ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852021-12-011910.31744/einstein_journal/2021ao6739Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort studyThiago Domingos Corrêahttps://orcid.org/0000-0001-9546-3910Thais Dias Midegahttps://orcid.org/0000-0002-1010-3711Karina Tavares Timenetskyhttps://orcid.org/0000-0002-4176-2445Ricardo Luiz Cordiolihttps://orcid.org/0000-0001-7521-399XCarmen Silvia Valente Barbashttps://orcid.org/0000-0002-3922-6256Moacyr Silva Júniorhttps://orcid.org/0000-0002-6479-1708Bruno de Arruda Bravimhttps://orcid.org/0000-0001-8290-8554Bruno Caldin Silvahttps://orcid.org/0000-0001-9568-0974Gustavo Faissol Janot de Matoshttps://orcid.org/0000-0001-9996-7040Ricardo Kenji Nawahttps://orcid.org/0000-0002-0852-7013Fabrício Rodrigues Torres de Carvalhohttps://orcid.org/0000-0001-8712-269XVerônica Neves Fialho Queirozhttps://orcid.org/0000-0001-5213-0147Roberto Rabello Filhohttps://orcid.org/0000-0001-7018-224XFelipe Maia de Toledo Pizahttps://orcid.org/0000-0002-7729-9579Adriano José Pereirahttps://orcid.org/0000-0002-9467-6516Marcele Liliane Pesaventohttps://orcid.org/0000-0001-7391-8208Raquel Afonso Caserta Eidhttps://orcid.org/0000-0002-8241-3241Bento Fortunato Cardoso dos Santoshttps://orcid.org/0000-0002-4662-1959Andreia Pardinihttps://orcid.org/0000-0002-9810-0100Vanessa Damázio Teichhttps://orcid.org/0000-0002-8539-6037Claudia Regina Laselvahttps://orcid.org/0000-0001-8285-9633Miguel Cendoroglo Netohttps://orcid.org/0000-0002-8163-4392Sidney Klajnerhttps://orcid.org/0000-0003-4120-1047Leonardo José Rolim Ferrazhttps://orcid.org/0000-0003-1822-1568ABSTRACT Objective: To describe clinical characteristics, resource use, outcomes, and to identify predictors of in-hospital mortality of patients with COVID-19 admitted to the intensive care unit. Methods: Retrospective single-center cohort study conducted at a private hospital in São Paulo (SP), Brazil. All consecutive adult (≥18 years) patients admitted to the intensive care unit, between March 4, 2020 and February 28, 2021 were included in this study. Patients were categorized between survivors and non-survivors according to hospital discharge. Results: During the study period, 1,296 patients [median (interquartile range) age: 66 (53-77) years] with COVID-19 were admitted to the intensive care unit. Out of those, 170 (13.6%) died at hospital (non-survivors) and 1,078 (86.4%) were discharged (survivors). Compared to survivors, non-survivors were older [80 (70-88) versus 63 (50-74) years; p<0.001], had a higher Simplified Acute Physiology Score 3 [59 (54-66) versus 47 (42-53) points; p<0.001], and presented comorbidities more frequently. During the intensive care unit stay, 56.6% of patients received noninvasive ventilation, 32.9% received mechanical ventilation, 31.3% used high flow nasal cannula, 11.7% received renal replacement therapy, and 1.5% used extracorporeal membrane oxygenation. Independent predictors of in-hospital mortality included age, Sequential Organ Failure Assessment score, Charlson Comorbidity Index, need for mechanical ventilation, high flow nasal cannula, renal replacement therapy, and extracorporeal membrane oxygenation support. Conclusion: Patients with severe COVID-19 admitted to the intensive care unit exhibited a considerable morbidity and mortality, demanding substantial organ support, and prolonged intensive care unit and hospital stay.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100251&tlng=ptCoronavirusCOVID-19Coronavirus infectionsSARS-CoV-2BetacoronavirusIntensive care unitsRespiration, artificialNoninvasive ventilationExtracorporeal membrane oxygenationCritical care outcomesMortality |
| spellingShingle | Thiago Domingos Corrêa Thais Dias Midega Karina Tavares Timenetsky Ricardo Luiz Cordioli Carmen Silvia Valente Barbas Moacyr Silva Júnior Bruno de Arruda Bravim Bruno Caldin Silva Gustavo Faissol Janot de Matos Ricardo Kenji Nawa Fabrício Rodrigues Torres de Carvalho Verônica Neves Fialho Queiroz Roberto Rabello Filho Felipe Maia de Toledo Piza Adriano José Pereira Marcele Liliane Pesavento Raquel Afonso Caserta Eid Bento Fortunato Cardoso dos Santos Andreia Pardini Vanessa Damázio Teich Claudia Regina Laselva Miguel Cendoroglo Neto Sidney Klajner Leonardo José Rolim Ferraz Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study Einstein (São Paulo) Coronavirus COVID-19 Coronavirus infections SARS-CoV-2 Betacoronavirus Intensive care units Respiration, artificial Noninvasive ventilation Extracorporeal membrane oxygenation Critical care outcomes Mortality |
| title | Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study |
| title_full | Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study |
| title_fullStr | Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study |
| title_full_unstemmed | Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study |
| title_short | Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study |
| title_sort | clinical characteristics and outcomes of covid 19 patients admitted to the intensive care unit during the first year of the pandemic in brazil a single center retrospective cohort study |
| topic | Coronavirus COVID-19 Coronavirus infections SARS-CoV-2 Betacoronavirus Intensive care units Respiration, artificial Noninvasive ventilation Extracorporeal membrane oxygenation Critical care outcomes Mortality |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100251&tlng=pt |
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