Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria

Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria

Microbial cleavage of dimethylsulfoniopropionate (DMSP) producing dimethyl sulfide (DMS) and acrylate is an important step in global sulfur cycling. Acrylate is toxic for cells, and thus should be metabolized effectively for detoxification. There are two proposed pathways for acrylate metabolism in...

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Bibliographic Details
Main Authors: Hai-Yan Cao, Peng Wang, Fei Xu, Ping-Yi Li, Bin-Bin Xie, Qi-Long Qin, Yu-Zhong Zhang, Chun-Yang Li, Xiu-Lan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Microbiology
Subjects:
DMSP
acrylate
detoxification
acryloyl-CoA hydratase
catalytic mechanism
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02034/full

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