Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children
Abstract Background This study aimed to identify an initial screening tool for congenital ectopia lentis (CEL) by comparing ocular biological parameters in children with myopia. Methods A retrospective case-control study was conducted at one tertiary referral centre, from October 2020 to June 2022....
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-03230-7 |
| _version_ | 1797415685074190336 |
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| author | Jiaona Jing Qingwei Meng Wei Gu Haixia Cheng Kun Li Yuming Li Qinghuai Liu |
| author_facet | Jiaona Jing Qingwei Meng Wei Gu Haixia Cheng Kun Li Yuming Li Qinghuai Liu |
| author_sort | Jiaona Jing |
| collection | DOAJ |
| description | Abstract Background This study aimed to identify an initial screening tool for congenital ectopia lentis (CEL) by comparing ocular biological parameters in children with myopia. Methods A retrospective case-control study was conducted at one tertiary referral centre, from October 2020 to June 2022. Axial length (AL), corneal curvature (CC), refractive astigmatism (RA), corneal astigmatism (CA), internal astigmatism (IA), the difference between the axis of RA and CA [AXIS(RA-CA)], white-to-white corneal diameter (WTW), and axial length-corneal radius ratio (AL/CR) were compared in 28 eyes of CEL patients, and 60 eyes of myopic patients matched for age and refraction. The spherical equivalent of each eye was < -3.00 D. Area under the curve (AUC) of the receiver operating characteristic curves were calculated. Results The differences in RA, AL, mean keratometry (Kmed), maximum keratometry (Kmax), minimum keratometry (Kmin), CA, IA, AXIS(RA-CA), WTW, and AL/CR between the CEL and myopic groups were statistically significant (p < 0.05; p < 0.001; p < 0.001; p < 0.001; p < 0.001; p < 0.05; p < 0.001; p < 0.001; p < 0.001; p < 0.001, respectively). In logistic regression analysis RA, IA, AXIS(RA-CA), and AL/CR were significantly associated with CEL (p < 0.05). AUCs for RA, IA, AXIS(RA-CA), and AL/CR were 0.694, 0.853, 0.814, and 0.960, respectively. AUCs for AL/CR in SE< -6.00 D subgroup was 0.970, and 0.990 in -6.00 D ≤ SE < -3.00 D group. An AL/CR < 3.024 was the optimal cut-off point differentiating the CEL and control groups (sensitivity, 92.9%; specificity, 88.30%). Conclusions A smaller AL/CR could identify CEL in children with myopia. An AL/CR cut-off value of 3.024 may be the most sensitive and specific parameter for the differential diagnosis of CEL in patients with mild to high myopia. |
| first_indexed | 2024-03-09T05:53:04Z |
| format | Article |
| id | doaj.art-43a888dbd59a4000b79a2df28e77561d |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-09T05:53:04Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj.art-43a888dbd59a4000b79a2df28e77561d2023-12-03T12:15:49ZengBMCBMC Ophthalmology1471-24152023-11-012311910.1186/s12886-023-03230-7Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool childrenJiaona Jing0Qingwei Meng1Wei Gu2Haixia Cheng3Kun Li4Yuming Li5Qinghuai Liu6Department of Ophthalmology, Children’s Hospital of Nanjing Medical UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Kunming Medical UniversityDepartment of Medical, Children’s Hospital of Nanjing Medical UniversityDepartment of Ophthalmology, Children’s Hospital of Nanjing Medical UniversityDepartment of Ophthalmology, Children’s Hospital of Nanjing Medical UniversityHarris Laboratory, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Background This study aimed to identify an initial screening tool for congenital ectopia lentis (CEL) by comparing ocular biological parameters in children with myopia. Methods A retrospective case-control study was conducted at one tertiary referral centre, from October 2020 to June 2022. Axial length (AL), corneal curvature (CC), refractive astigmatism (RA), corneal astigmatism (CA), internal astigmatism (IA), the difference between the axis of RA and CA [AXIS(RA-CA)], white-to-white corneal diameter (WTW), and axial length-corneal radius ratio (AL/CR) were compared in 28 eyes of CEL patients, and 60 eyes of myopic patients matched for age and refraction. The spherical equivalent of each eye was < -3.00 D. Area under the curve (AUC) of the receiver operating characteristic curves were calculated. Results The differences in RA, AL, mean keratometry (Kmed), maximum keratometry (Kmax), minimum keratometry (Kmin), CA, IA, AXIS(RA-CA), WTW, and AL/CR between the CEL and myopic groups were statistically significant (p < 0.05; p < 0.001; p < 0.001; p < 0.001; p < 0.001; p < 0.05; p < 0.001; p < 0.001; p < 0.001; p < 0.001, respectively). In logistic regression analysis RA, IA, AXIS(RA-CA), and AL/CR were significantly associated with CEL (p < 0.05). AUCs for RA, IA, AXIS(RA-CA), and AL/CR were 0.694, 0.853, 0.814, and 0.960, respectively. AUCs for AL/CR in SE< -6.00 D subgroup was 0.970, and 0.990 in -6.00 D ≤ SE < -3.00 D group. An AL/CR < 3.024 was the optimal cut-off point differentiating the CEL and control groups (sensitivity, 92.9%; specificity, 88.30%). Conclusions A smaller AL/CR could identify CEL in children with myopia. An AL/CR cut-off value of 3.024 may be the most sensitive and specific parameter for the differential diagnosis of CEL in patients with mild to high myopia.https://doi.org/10.1186/s12886-023-03230-7Congenital ectopia lentisMyopiaBiological parametersAxial length-corneal radius ratioPreschool children |
| spellingShingle | Jiaona Jing Qingwei Meng Wei Gu Haixia Cheng Kun Li Yuming Li Qinghuai Liu Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children BMC Ophthalmology Congenital ectopia lentis Myopia Biological parameters Axial length-corneal radius ratio Preschool children |
| title | Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children |
| title_full | Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children |
| title_fullStr | Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children |
| title_full_unstemmed | Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children |
| title_short | Initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children |
| title_sort | initial screening for occult congenital ectopia lentis based on ocular biological parameters in preschool children |
| topic | Congenital ectopia lentis Myopia Biological parameters Axial length-corneal radius ratio Preschool children |
| url | https://doi.org/10.1186/s12886-023-03230-7 |
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