Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules
Tissue engineering needs bioactive drug delivery scaffolds capable of guiding cell biosynthesis and tissue morphogenesis in three dimensions. Several strategies have been developed to design and fabricate ECM-mimicking scaffolds suitable for directing in vitro cell/scaffold interaction, and controll...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/14/2/101 |
| _version_ | 1797620113971609600 |
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| author | Aurelio Salerno Paolo Antonio Netti |
| author_facet | Aurelio Salerno Paolo Antonio Netti |
| author_sort | Aurelio Salerno |
| collection | DOAJ |
| description | Tissue engineering needs bioactive drug delivery scaffolds capable of guiding cell biosynthesis and tissue morphogenesis in three dimensions. Several strategies have been developed to design and fabricate ECM-mimicking scaffolds suitable for directing in vitro cell/scaffold interaction, and controlling tissue morphogenesis in vivo. Among these strategies, emerging computer aided design and manufacturing processes, such as modular tissue unit patterning, promise to provide unprecedented control over the generation of biologically and biomechanically competent tissue analogues. This review discusses recent studies and highlights the role of scaffold microstructural properties and their drug release capability in cell fate control and tissue morphogenesis. Furthermore, the work highlights recent advances in the bottom-up fabrication of porous scaffolds and hybrid constructs through the computer-aided assembly of cell-free and/or cell-laden micro-modules. The advantages, current limitations, and future challenges of these strategies are described and discussed. |
| first_indexed | 2024-03-11T08:37:03Z |
| format | Article |
| id | doaj.art-43aa5ef842684d5baf1dcf6289aac539 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T08:37:03Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-43aa5ef842684d5baf1dcf6289aac5392023-11-16T21:24:40ZengMDPI AGJournal of Functional Biomaterials2079-49832023-02-0114210110.3390/jfb14020101Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-ModulesAurelio Salerno0Paolo Antonio Netti1Department of Chemical, Materials, and Industrial Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, ItalyDepartment of Chemical, Materials, and Industrial Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, ItalyTissue engineering needs bioactive drug delivery scaffolds capable of guiding cell biosynthesis and tissue morphogenesis in three dimensions. Several strategies have been developed to design and fabricate ECM-mimicking scaffolds suitable for directing in vitro cell/scaffold interaction, and controlling tissue morphogenesis in vivo. Among these strategies, emerging computer aided design and manufacturing processes, such as modular tissue unit patterning, promise to provide unprecedented control over the generation of biologically and biomechanically competent tissue analogues. This review discusses recent studies and highlights the role of scaffold microstructural properties and their drug release capability in cell fate control and tissue morphogenesis. Furthermore, the work highlights recent advances in the bottom-up fabrication of porous scaffolds and hybrid constructs through the computer-aided assembly of cell-free and/or cell-laden micro-modules. The advantages, current limitations, and future challenges of these strategies are described and discussed.https://www.mdpi.com/2079-4983/14/2/101CAD scaffoldmicro-modulesmodular tissue engineeringtissue spheroids |
| spellingShingle | Aurelio Salerno Paolo Antonio Netti Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules Journal of Functional Biomaterials CAD scaffold micro-modules modular tissue engineering tissue spheroids |
| title | Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules |
| title_full | Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules |
| title_fullStr | Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules |
| title_full_unstemmed | Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules |
| title_short | Review on Bioinspired Design of ECM-Mimicking Scaffolds by Computer-Aided Assembly of Cell-Free and Cell Laden Micro-Modules |
| title_sort | review on bioinspired design of ecm mimicking scaffolds by computer aided assembly of cell free and cell laden micro modules |
| topic | CAD scaffold micro-modules modular tissue engineering tissue spheroids |
| url | https://www.mdpi.com/2079-4983/14/2/101 |
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