Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample
This study examined the association between genetic variations in the Vitamin D Receptor (VDR) gene and the composition of gut microbiota in a Spanish population. The VDR gene plays a role in mediating the effects of vitamin D on gut microbiota composition. We analyzed 87 healthy participants from t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/29/1/4 |
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| author | Rocío González Soltero Carlo Bressa Mariangela Tabone Sara Clemente Mar Larrosa María Bailén |
| author_facet | Rocío González Soltero Carlo Bressa Mariangela Tabone Sara Clemente Mar Larrosa María Bailén |
| author_sort | Rocío González Soltero |
| collection | DOAJ |
| description | This study examined the association between genetic variations in the Vitamin D Receptor (VDR) gene and the composition of gut microbiota in a Spanish population. The VDR gene plays a role in mediating the effects of vitamin D on gut microbiota composition. We analyzed 87 healthy participants from the Spanish Caucasian population and found that the genetic variations were in Hardy–Weinberg equilibrium. Through metataxonomic sequencing, we identified that the GG genotype from the VDR polymorphism rs731236 seems to be associated with the opportunistic genus <i>Solobacterium</i>, indicating that genetic variations may influence the composition of gut microbiota. |
| first_indexed | 2024-04-24T18:28:56Z |
| format | Article |
| id | doaj.art-43ac62df8ff04be4b03cb6d5bf74c3d4 |
| institution | Directory Open Access Journal |
| issn | 2673-9976 |
| language | English |
| last_indexed | 2024-04-24T18:28:56Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj.art-43ac62df8ff04be4b03cb6d5bf74c3d42024-03-27T13:28:31ZengMDPI AGBiology and Life Sciences Forum2673-99762023-10-01291410.3390/IECN2023-15530Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population SampleRocío González Soltero0Carlo Bressa1Mariangela Tabone2Sara Clemente3Mar Larrosa4María Bailén5Department of Biosciences, European University of Madrid, 28670 Madrid, SpainDepartment of Biomedicine, Universidad Francisco de Vitoria, 28223 Madrid, SpainPre-Clinical Dentistry Department, European University of Madrid, 28670 Madrid, SpainPre-Clinical Dentistry Department, European University of Madrid, 28670 Madrid, SpainNutrition and Food Sciences Department, Faculty of Pharmacy, University Complutense of Madrid, 28040 Madrid, SpainPreventive Medicine and Public Health and Microbiology Center, Faculty of Medicine, University Autónoma of Madrid, 28049 Madrid, SpainThis study examined the association between genetic variations in the Vitamin D Receptor (VDR) gene and the composition of gut microbiota in a Spanish population. The VDR gene plays a role in mediating the effects of vitamin D on gut microbiota composition. We analyzed 87 healthy participants from the Spanish Caucasian population and found that the genetic variations were in Hardy–Weinberg equilibrium. Through metataxonomic sequencing, we identified that the GG genotype from the VDR polymorphism rs731236 seems to be associated with the opportunistic genus <i>Solobacterium</i>, indicating that genetic variations may influence the composition of gut microbiota.https://www.mdpi.com/2673-9976/29/1/4Vitamin D Receptor (VDR) polymorphismsgut microbiotaSpanish populationrs2731236Lefse |
| spellingShingle | Rocío González Soltero Carlo Bressa Mariangela Tabone Sara Clemente Mar Larrosa María Bailén Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample Biology and Life Sciences Forum Vitamin D Receptor (VDR) polymorphisms gut microbiota Spanish population rs2731236 Lefse |
| title | Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample |
| title_full | Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample |
| title_fullStr | Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample |
| title_full_unstemmed | Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample |
| title_short | Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample |
| title_sort | associations between vitamin d receptor vdr polymorphisms and gut microbiota in a spanish population sample |
| topic | Vitamin D Receptor (VDR) polymorphisms gut microbiota Spanish population rs2731236 Lefse |
| url | https://www.mdpi.com/2673-9976/29/1/4 |
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