Case report: Intraneural perineurioma in dogs: a case series and brief literature review
Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural peri...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1233230/full |
| _version_ | 1797357695516278784 |
|---|---|
| author | Ji-Hang Yin Brittani Sexton Tom Jukier Amy B. Yanke Merrilee Holland Andrew D. Miller Lauren Stranahan Aline Rodrigues Hoffmann Maninder Sandey |
| author_facet | Ji-Hang Yin Brittani Sexton Tom Jukier Amy B. Yanke Merrilee Holland Andrew D. Miller Lauren Stranahan Aline Rodrigues Hoffmann Maninder Sandey |
| author_sort | Ji-Hang Yin |
| collection | DOAJ |
| description | Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance. Clinical signs associated with intraneural perineurioma in dogs include spinal pain, lameness, and paresis, resulting from the involvement of spinal nerve roots of the pelvic limbs, brachial plexus, or distal part of the median nerve. Most neoplasms had characteristic pseudo-onion bulb patterns on histopathology. Neoplastic perineurial cells, in most cases, expressed laminin and claudin-1, and NF200 consistently highlighted the central axon. While the immunohistochemical (IHC) profile of intraneural perineurioma in veterinary medicine remains incompletely characterized, the available IHC data from all reported cases suggest that a combination of laminin and claudin-1 immunomarkers, along with distinctive histological features, can assist in establishing a definitive diagnosis of intraneural perineurioma. |
| first_indexed | 2024-03-08T14:48:51Z |
| format | Article |
| id | doaj.art-43acd5d9ab3a47dba266ece0754ff0b3 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-08T14:48:51Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-43acd5d9ab3a47dba266ece0754ff0b32024-01-11T04:54:05ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-01-011010.3389/fvets.2023.12332301233230Case report: Intraneural perineurioma in dogs: a case series and brief literature reviewJi-Hang Yin0Brittani Sexton1Tom Jukier2Amy B. Yanke3Merrilee Holland4Andrew D. Miller5Lauren Stranahan6Aline Rodrigues Hoffmann7Maninder Sandey8Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesDepartment of Population Medicine and Diagnostic Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, United StatesDepartment of Veterinary Pathobiology, Texas A&M School of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Veterinary Pathobiology, Texas A&M School of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesIntraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance. Clinical signs associated with intraneural perineurioma in dogs include spinal pain, lameness, and paresis, resulting from the involvement of spinal nerve roots of the pelvic limbs, brachial plexus, or distal part of the median nerve. Most neoplasms had characteristic pseudo-onion bulb patterns on histopathology. Neoplastic perineurial cells, in most cases, expressed laminin and claudin-1, and NF200 consistently highlighted the central axon. While the immunohistochemical (IHC) profile of intraneural perineurioma in veterinary medicine remains incompletely characterized, the available IHC data from all reported cases suggest that a combination of laminin and claudin-1 immunomarkers, along with distinctive histological features, can assist in establishing a definitive diagnosis of intraneural perineurioma.https://www.frontiersin.org/articles/10.3389/fvets.2023.1233230/fullcaninespinal nerve rootsintraneural perineuriomaimmunohistochemistrybrief literature review |
| spellingShingle | Ji-Hang Yin Brittani Sexton Tom Jukier Amy B. Yanke Merrilee Holland Andrew D. Miller Lauren Stranahan Aline Rodrigues Hoffmann Maninder Sandey Case report: Intraneural perineurioma in dogs: a case series and brief literature review Frontiers in Veterinary Science canine spinal nerve roots intraneural perineurioma immunohistochemistry brief literature review |
| title | Case report: Intraneural perineurioma in dogs: a case series and brief literature review |
| title_full | Case report: Intraneural perineurioma in dogs: a case series and brief literature review |
| title_fullStr | Case report: Intraneural perineurioma in dogs: a case series and brief literature review |
| title_full_unstemmed | Case report: Intraneural perineurioma in dogs: a case series and brief literature review |
| title_short | Case report: Intraneural perineurioma in dogs: a case series and brief literature review |
| title_sort | case report intraneural perineurioma in dogs a case series and brief literature review |
| topic | canine spinal nerve roots intraneural perineurioma immunohistochemistry brief literature review |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1233230/full |
| work_keys_str_mv | AT jihangyin casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT brittanisexton casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT tomjukier casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT amybyanke casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT merrileeholland casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT andrewdmiller casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT laurenstranahan casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT alinerodrigueshoffmann casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview AT manindersandey casereportintraneuralperineuriomaindogsacaseseriesandbriefliteraturereview |