Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient
Strongyloides stercoralis hyperinfection syndrome is classically associated with impaired host response and implies in an overburden of larvae in its usual cycle. It has been recognized as a severe and potentially fatal condition in immunocompromised individuals, especially those using oral corticos...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2012-12-01
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| Series: | Autopsy and Case Reports |
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| Online Access: | http://www.revistas.usp.br/autopsy/article/view/48323 |
| _version_ | 1828901464721850368 |
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| author | Rodrigo Martins Brandão Renata Paula Martins Brandão Amanda Cristina Maria Aparecida Gonçalves Lorena Silva Laborda Patricia Picciarelli de Lima Fernando Peixoto Ferraz de Campos |
| author_facet | Rodrigo Martins Brandão Renata Paula Martins Brandão Amanda Cristina Maria Aparecida Gonçalves Lorena Silva Laborda Patricia Picciarelli de Lima Fernando Peixoto Ferraz de Campos |
| author_sort | Rodrigo Martins Brandão |
| collection | DOAJ |
| description | Strongyloides stercoralis hyperinfection syndrome is classically associated with impaired host response and implies in an overburden of larvae in its usual cycle. It has been recognized as a severe and potentially fatal condition in immunocompromised individuals, especially those using oral corticosteroids. Infection with Schistosoma mansoni not only increases the susceptibility to HIV infection, but also promotes progression to disease. The association of the most severe forms of strongyloidiasis and AIDS is scarcely described, even more when S. mansoni is also associated. The authors describe a case of a 34-year-old previously healthy male, admitted to the emergency department with a history of hematemesis associated with dyspnea, hemoptysis, and fever. He referred homosexual relations for 6 years. Physical examination showed an ill-looking patient, and was remarkable for tachycardia, tachypnea, diaphoresis, and pulse oximetry of 70% in room air. Lungs examination revealed the presence of rales in the left base. Chest radiography showed a diffuse and bilateral reticulo-nodular pattern. HIV serology was positive. Empirical antimicrobial therapy and corticosteroids were initiated. On the third day of hospitalization, petechiae appeared over the periumbilical area, but no further investigation was undertaken because the patient died soon after. The autopsy findings were compatible with S. stercoralis disseminated infection, a hepatic intestinal chronic form of schistosomiasis, and septic shock as the primary cause of death. The authors call attention to this infrequent association. |
| first_indexed | 2024-12-13T16:00:59Z |
| format | Article |
| id | doaj.art-43ae2b9e43e0497ea9e497fd951a86f2 |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-13T16:00:59Z |
| publishDate | 2012-12-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-43ae2b9e43e0497ea9e497fd951a86f22022-12-21T23:39:10ZengUniversity of São PauloAutopsy and Case Reports2236-19602012-12-012448016Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patientRodrigo Martins Brandão0Renata Paula Martins Brandão1Amanda Cristina Maria Aparecida Gonçalves2Lorena Silva Laborda3Patricia Picciarelli de Lima4Fernando Peixoto Ferraz de Campos5Department of Internal Medicine, Hospital Universitário, Universidade de São PauloDepartment of Nephrology, Beneficência Portuguesa de São PauloNursing Departament, Hospital Israelita Albert EinsteinDepartment of Internal Medicine, Hospital Universitário, Universidade de São PauloAnatomic Pathology Service, Hospital Universitário, Universidade de São PauloDepartment of Internal Medicine, Hospital Universitário, Universidade de São PauloStrongyloides stercoralis hyperinfection syndrome is classically associated with impaired host response and implies in an overburden of larvae in its usual cycle. It has been recognized as a severe and potentially fatal condition in immunocompromised individuals, especially those using oral corticosteroids. Infection with Schistosoma mansoni not only increases the susceptibility to HIV infection, but also promotes progression to disease. The association of the most severe forms of strongyloidiasis and AIDS is scarcely described, even more when S. mansoni is also associated. The authors describe a case of a 34-year-old previously healthy male, admitted to the emergency department with a history of hematemesis associated with dyspnea, hemoptysis, and fever. He referred homosexual relations for 6 years. Physical examination showed an ill-looking patient, and was remarkable for tachycardia, tachypnea, diaphoresis, and pulse oximetry of 70% in room air. Lungs examination revealed the presence of rales in the left base. Chest radiography showed a diffuse and bilateral reticulo-nodular pattern. HIV serology was positive. Empirical antimicrobial therapy and corticosteroids were initiated. On the third day of hospitalization, petechiae appeared over the periumbilical area, but no further investigation was undertaken because the patient died soon after. The autopsy findings were compatible with S. stercoralis disseminated infection, a hepatic intestinal chronic form of schistosomiasis, and septic shock as the primary cause of death. The authors call attention to this infrequent association.http://www.revistas.usp.br/autopsy/article/view/48323Acquired immunodeficiency syndromeStrongyloides stercoralisSchistosoma mansoniRespiratory insufficiencyAutopsy. |
| spellingShingle | Rodrigo Martins Brandão Renata Paula Martins Brandão Amanda Cristina Maria Aparecida Gonçalves Lorena Silva Laborda Patricia Picciarelli de Lima Fernando Peixoto Ferraz de Campos Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient Autopsy and Case Reports Acquired immunodeficiency syndrome Strongyloides stercoralis Schistosoma mansoni Respiratory insufficiency Autopsy. |
| title | Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient |
| title_full | Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient |
| title_fullStr | Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient |
| title_full_unstemmed | Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient |
| title_short | Strongyloides stercoralis disseminated infection and schistosomiasis in an AIDS patient |
| title_sort | strongyloides stercoralis disseminated infection and schistosomiasis in an aids patient |
| topic | Acquired immunodeficiency syndrome Strongyloides stercoralis Schistosoma mansoni Respiratory insufficiency Autopsy. |
| url | http://www.revistas.usp.br/autopsy/article/view/48323 |
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