Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3

Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that contributes to cancer progression through multiple processes of cancer development, which makes it an attractive target for cancer therapy. The IL-6/STAT3 pathway is associated with an advanced stage in colorec...

Full description

Bibliographic Details
Main Authors:	Xin Qi, Meng Li, Xiao-min Zhang, Xiu-fen Dai, Jian Cui, De-hai Li, Qian-qun Gu, Zhi-hua Lv, Jing Li
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	Molecules
Subjects:	cancer trichothecin STAT3 inhibitor HCT 116
Online Access:	https://www.mdpi.com/1420-3049/25/10/2306

Similar Items

DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma
by: Xiangjian Luo, et al.
Published: (2019-07-01)

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia
by: Joshua R. Huot, et al.
Published: (2020-01-01)

Berberine Inhibits Telomerase Activity and Induces Cell Cycle Arrest and Telomere Erosion in Colorectal Cancer Cell Line, HCT 116
by: Muhammad Azizan Samad, et al.
Published: (2021-01-01)

Anti-migration Effect of Aaptos suberitoides Fraction in HCT-116 Colorectal Cancer Cell Line
by: Dany Muhammad Daffa, et al.
Published: (2021-03-01)

Cytotoxic Effects of Lactobacilli Isolated from Azerbaijan Traditional Cheeses on Colorectal Tumor Cells HCT 116 and Identification of Paramount Strains
by: Mitra Rabiei, et al.
Published: (2018-07-01)

Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents
by: Tian Luan, et al.
Published: (2018-12-01)

Exploring the effect of silver nanoparticles on gene expression in colon cancer cell line HCT116
by: Alobaid Hussah M., et al.
Published: (2022-12-01)

Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
by: Xiaobo Nie, et al.
Published: (2019-10-01)

Micropropagation of Rare <i>Scutellaria havanensis</i> Jacq. and Preliminary Studies on Antioxidant Capacity and Anti-Cancer Potential
by: Lani Irvin, et al.
Published: (2021-09-01)

The Inhibitory Effects of Lactobacillus Reuteri’s Cell Wall on Cell Proliferation in the HCT-116 Colorectal Cancer Cell Line
by: Zahra Rafiei Atani, et al.
Published: (2018-08-01)

Bcl-2-associated athanogene 3(BAG3) is associated with tumor cell proliferation, migration, invasion and chemoresistance in colorectal cancer
by: Ning Li, et al.
Published: (2018-08-01)

Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
by: Boqiao Fu, et al.
Published: (2021-02-01)

Lactobacillus casei UT1 Isolated from Northwest of Iran Traditional Curd Exerts Anti-proliferative and Apoptosis Inducing Effects in Human Colorectal Tumor HCT 116 Cells
by: Mitra Rabiei, et al.
Published: (2020-01-01)

Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway
by: Wen Zhang, et al.
Published: (2021-11-01)

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
by: Su M, et al.
Published: (2017-11-01)

Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116
by: Sala Cesare, et al.
Published: (2023-06-01)

Regulatory Effects of Apatinib in Combination with Piperine on MDM-2 Gene Expression, Glutathione Peroxidase Activity and Nitric Oxide level as Mechanisms of Cytotoxicity in Colorectal Cancer Cells
by: Mahshid Mohammadian, et al.
Published: (2022-03-01)

Role of the transient receptor potential melastatin 4 in inhibition effect of arsenic trioxide on the tumor biological features of colorectal cancer cell
by: Zhan Gao, et al.
Published: (2024-06-01)

Expression of T399I and D299G polymorphisms of TLR4 gene in colorectal cancer cell line by flowcytometery
by: Davoodi H, et al.
Published: (2013-06-01)

Induction of autophagy by oleifolioside A in HCT-116 human colorectal cancer cells
by: So-Young An, et al.
Published: (2023-06-01)

Mesenchymal stem cells- derived exosomes inhibit the expression of Aquaporin-5 and EGFR in HCT-116 human colorectal carcinoma cell line
by: Amir Hossein Mansourabadi, et al.
Published: (2022-09-01)

Expression of β-Catenin Marker in Colorectal Cancer Cells after Treatment with Royal Jelly
by: Milena M. Jovanović, et al.
Published: (2022-11-01)

Isolation and identification of anti-colorectal cancer peptides from walnut proteins and associated in silico analysis
by: Jing Xie, et al.
Published: (2024-01-01)

Decreasing the ability of HCT116 cells to escape from therapy induced senescence by increasing the duration of doxorubicin treatment
by: N. A. Persiyantseva, et al.
Published: (2024-04-01)

Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
by: Katsuhiro Ueda, et al.
Published: (2008-03-01)

Salidroside promotes apoptosis of human HCT116 colon cancer cells by regulating Wnt/β-catenin signaling pathway
by: Lijuan Cui, et al.
Published: (2022-06-01)

A Novel N-Sulfonylamidine-Based Derivative Inhibits Proliferation, Migration, and Invasion in Human Colorectal Cancer Cells by Suppressing Wnt/β-Catenin Signaling Pathway
by: Xingming Zhao, et al.
Published: (2021-05-01)

Cytotoxic effects of the newly-developed chemotherapeutic agents 17-AAG in combination with oxaliplatin and capecitabine in colorectal cancer cell lines
by: Mahshid Mohammadian, et al.
Published: (2017-01-01)

Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy
by: Ram Siripuram, et al.
Published: (2022-03-01)

Effect and mechanism of miR-135b on apoptosis of HCT116 colon cancer cells
by: Xiao-hong ZHANG, et al.
Published: (2022-06-01)

GB7 acetate, a galbulimima alkaloid from Galbulimima belgraveana, possesses anticancer effects in colorectal cancer cells
by: Ziyin Li, et al.
Published: (2022-04-01)

Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene)bis(pyrimidin-2-amine) derivatives
by: Sanjiv Kumar, et al.
Published: (2018-06-01)

Investigation of presence of folate on physicochemical and anticancer properties of beta-lactoglobulin nanocapsules against human colon cancer cell line of HTC116
by: Mahdieh Garshasbi, et al.
Published: (2021-10-01)

Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Argyreia nervosa Extract in Colorectal Cancer Cells
by: Fayyaz Rasool, et al.
Published: (2021-09-01)

Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway
by: Lei C, et al.
Published: (2019-09-01)

Chitinase inhibits growth of human breast and colorectal cancer cells in vitro and Ehrlich ascites carcinoma cells in vivo
by: Syed Rashel Kabir, et al.
Published: (2022-11-01)

Novel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway
by: Yuying Li, et al.
Published: (2020-04-01)

Effects of NDUFA4 Overexpression on Growth of Human Colon Cancer Cells in vitro
by: LIU Shiming, et al.
Published: (2019-05-01)

Artemisia monosperma induces ROS-mediated cell death in human colorectal carcinoma cells via modulating apoptotic genes
by: Nida N. Farshori, et al.
Published: (2023-08-01)

Design, synthesis and antitumor activity of 3,4,5-Trisubstituted Isoxazoles
by: Kanghui Duan, et al.
Published: (2024-12-01)