Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain
Chronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/8057854 |
| _version_ | 1827008391204044800 |
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| author | Jie Liu Jingyao Huang Zhenjiang Zhang Rui Zhang Zhihao Zhang Yongxin Liu Baoyu Ma |
| author_facet | Jie Liu Jingyao Huang Zhenjiang Zhang Rui Zhang Zhihao Zhang Yongxin Liu Baoyu Ma |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Chronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly localized in the outer mitochondrial membrane. Recent and increasing studies have found changes in TSPO and its ligands in various chronic pain models. Reversing their expressions has been shown to alleviate chronic pain in these models, illustrating the effects of TSPO and its ligands. Herein, we review recent evidence and the mechanisms of TSPO in the development of chronic pain associated with peripheral nerve injury, spinal cord injury, cancer, and inflammatory responses. The cumulative evidence indicates that TSPO-based therapy may become an alternative strategy for treating chronic pain. |
| first_indexed | 2024-04-11T09:57:04Z |
| format | Article |
| id | doaj.art-43afb48384c64d9eb63052fe0262165a |
| institution | Directory Open Access Journal |
| issn | 1687-5443 |
| language | English |
| last_indexed | 2025-02-18T12:33:06Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj.art-43afb48384c64d9eb63052fe0262165a2024-11-02T04:15:21ZengHindawi LimitedNeural Plasticity1687-54432022-01-01202210.1155/2022/8057854Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic PainJie Liu0Jingyao Huang1Zhenjiang Zhang2Rui Zhang3Zhihao Zhang4Yongxin Liu5Baoyu Ma6Shandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaDepartment of Thoracic SurgeryShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaChronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly localized in the outer mitochondrial membrane. Recent and increasing studies have found changes in TSPO and its ligands in various chronic pain models. Reversing their expressions has been shown to alleviate chronic pain in these models, illustrating the effects of TSPO and its ligands. Herein, we review recent evidence and the mechanisms of TSPO in the development of chronic pain associated with peripheral nerve injury, spinal cord injury, cancer, and inflammatory responses. The cumulative evidence indicates that TSPO-based therapy may become an alternative strategy for treating chronic pain.http://dx.doi.org/10.1155/2022/8057854 |
| spellingShingle | Jie Liu Jingyao Huang Zhenjiang Zhang Rui Zhang Zhihao Zhang Yongxin Liu Baoyu Ma Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain Neural Plasticity |
| title | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
| title_full | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
| title_fullStr | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
| title_full_unstemmed | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
| title_short | Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain |
| title_sort | translocator protein 18 kda tspo as a novel therapeutic target for chronic pain |
| url | http://dx.doi.org/10.1155/2022/8057854 |
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