Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases
Abstract Background Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient’s risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV ge...
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| Format: | Article |
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BMC
2021-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-021-06853-7 |
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| author | Ruizhe Chen Yunfeng Fu Bingbing You Ying Li Yeli Yao Xinyu Wang Xiaodong Cheng |
| author_facet | Ruizhe Chen Yunfeng Fu Bingbing You Ying Li Yeli Yao Xinyu Wang Xiaodong Cheng |
| author_sort | Ruizhe Chen |
| collection | DOAJ |
| description | Abstract Background Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient’s risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV genotypes is an important component of evaluation of cervical lesion. Data and evidence are necessary to gain a deeper understanding of the pathogenicity of different HPV genotypes. The present study investigated the clinical characteristics of patients infected with single human papillomavirus (HPV) 53. Methods This retrospective study analyzed the clinical data of patients who underwent cervical colposcopy guided biopsy between October 2015 and January 2021. The clinical outcomes and the follow-up results of the patients with single HPV53 infection were described. Results 82.3% of the initial histological results of all 419 patients with single HPV53 infection showed negative (Neg). The number of patients with cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, vaginal intraepithelial neoplasia (VaIN)1, CIN1 + VaIN1, CIN1 + VaIN2, and CIN2 + VaIN2 was 45, 10, 2, 9, 6, 1, and 1, respectively. Cancer was not detected in any patient. When the cytology was negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL), we observed a significant difference in the distribution of histological results (P < 0.05). 95 patients underwent follow-up with cytology according to the exclusion criteria. No progression of high-grade lesions was observed during the follow-up period of 3–34 months. Conclusions The lesion caused by HPV53 infection progressed slowly. The pathogenicity of a single HPV53 infection was low. |
| first_indexed | 2024-12-13T16:58:40Z |
| format | Article |
| id | doaj.art-43b0c9e3949b45409b1c17d61cc193c7 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T16:58:40Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-43b0c9e3949b45409b1c17d61cc193c72022-12-21T23:37:51ZengBMCBMC Infectious Diseases1471-23342021-11-012111710.1186/s12879-021-06853-7Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 casesRuizhe Chen0Yunfeng Fu1Bingbing You2Ying Li3Yeli Yao4Xinyu Wang5Xiaodong Cheng6Women’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineWomen’s Hospital, Zhejiang University School of MedicineAbstract Background Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient’s risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV genotypes is an important component of evaluation of cervical lesion. Data and evidence are necessary to gain a deeper understanding of the pathogenicity of different HPV genotypes. The present study investigated the clinical characteristics of patients infected with single human papillomavirus (HPV) 53. Methods This retrospective study analyzed the clinical data of patients who underwent cervical colposcopy guided biopsy between October 2015 and January 2021. The clinical outcomes and the follow-up results of the patients with single HPV53 infection were described. Results 82.3% of the initial histological results of all 419 patients with single HPV53 infection showed negative (Neg). The number of patients with cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, vaginal intraepithelial neoplasia (VaIN)1, CIN1 + VaIN1, CIN1 + VaIN2, and CIN2 + VaIN2 was 45, 10, 2, 9, 6, 1, and 1, respectively. Cancer was not detected in any patient. When the cytology was negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL), we observed a significant difference in the distribution of histological results (P < 0.05). 95 patients underwent follow-up with cytology according to the exclusion criteria. No progression of high-grade lesions was observed during the follow-up period of 3–34 months. Conclusions The lesion caused by HPV53 infection progressed slowly. The pathogenicity of a single HPV53 infection was low.https://doi.org/10.1186/s12879-021-06853-7Human papillomavirusCervical intraepithelial neoplasiaSingle infectionGenotype |
| spellingShingle | Ruizhe Chen Yunfeng Fu Bingbing You Ying Li Yeli Yao Xinyu Wang Xiaodong Cheng Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases BMC Infectious Diseases Human papillomavirus Cervical intraepithelial neoplasia Single infection Genotype |
| title | Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases |
| title_full | Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases |
| title_fullStr | Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases |
| title_full_unstemmed | Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases |
| title_short | Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases |
| title_sort | clinical characteristics of single human papillomavirus 53 infection a retrospective study of 419 cases |
| topic | Human papillomavirus Cervical intraepithelial neoplasia Single infection Genotype |
| url | https://doi.org/10.1186/s12879-021-06853-7 |
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