Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis
BackgroundCircular RNAs (circRNAs) are receiving increasing attention as novel biomarkers. Our goal was to investigate the diagnostic, clinicopathological, and prognostic utility of circRNAs in prostate cancer (PCa).MethodsRelevant literature was searched in PubMed, Web of Science, and EMBASE. Sensi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.945143/full |
| _version_ | 1798043882133389312 |
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| author | Jingling Xie Hui Jiang Yuanqing Zhao Xin rui Jin Baolin Li Zixin Zhu Limei Zhang Jinbo Liu |
| author_facet | Jingling Xie Hui Jiang Yuanqing Zhao Xin rui Jin Baolin Li Zixin Zhu Limei Zhang Jinbo Liu |
| author_sort | Jingling Xie |
| collection | DOAJ |
| description | BackgroundCircular RNAs (circRNAs) are receiving increasing attention as novel biomarkers. Our goal was to investigate the diagnostic, clinicopathological, and prognostic utility of circRNAs in prostate cancer (PCa).MethodsRelevant literature was searched in PubMed, Web of Science, and EMBASE. Sensitivity, specificity, diagnostic odds ratio (DOR), negative likelihood ratio (NLR), positive likelihood ratio (PLR), and the area under the curve (AUC) were calculated to evaluate the diagnostic accuracy of circRNA expression. circRNAs’ clinical, pathological, and prognostic value was examined using pooled odds ratios (ORs) and hazard ratios (HRs).ResultsThis meta-analysis included 23 studies, with 5 for diagnosis, 16 for clinicopathological parameters, and 10 for prognosis. For diagnostic value, the pooled sensitivity, pooled specificity, PLR, NLR, DOR, and AUC were 0.82, 0.62, 2.17, 0.29, 7.37, and 0.81, respectively. Upregulation of carcinogenic circRNAs was associated with poor clinical parameters (Gleason score: OR = 0.222, 95% CI: 0.145–0.340; T classification: OR = 0.274, 95% CI: 0.175–0.430; lymph node metastasis: OR = 0.353, 95% CI: 0.175–0.716; tumor size: OR = 0.226, 95% CI: 0.099–0.518) and could predict poor survival outcomes (HR = 2.408, 95% CI: 1.559–3.720, p < 0.001). Conversely, downregulation of tumor-suppressor circRNAs was also associated with poor clinical parameters (Gleason score: OR = 1.689, 95% CI: 1.144–2.493; T classification: OR = 2.586, 95% CI: 1.779–3.762) and worse prognosis (HR = 1.739, 95% CI: 1.147–2.576, p = 0.006).ConclusionOur results showed that circRNAs might be useful biomarkers for the diagnosis and prognosis of PCa.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021284785. |
| first_indexed | 2024-04-11T22:56:11Z |
| format | Article |
| id | doaj.art-43b3e811808947f2b818734170f831fe |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T22:56:11Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-43b3e811808947f2b818734170f831fe2022-12-22T03:58:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.945143945143Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysisJingling XieHui JiangYuanqing ZhaoXin rui JinBaolin LiZixin ZhuLimei ZhangJinbo LiuBackgroundCircular RNAs (circRNAs) are receiving increasing attention as novel biomarkers. Our goal was to investigate the diagnostic, clinicopathological, and prognostic utility of circRNAs in prostate cancer (PCa).MethodsRelevant literature was searched in PubMed, Web of Science, and EMBASE. Sensitivity, specificity, diagnostic odds ratio (DOR), negative likelihood ratio (NLR), positive likelihood ratio (PLR), and the area under the curve (AUC) were calculated to evaluate the diagnostic accuracy of circRNA expression. circRNAs’ clinical, pathological, and prognostic value was examined using pooled odds ratios (ORs) and hazard ratios (HRs).ResultsThis meta-analysis included 23 studies, with 5 for diagnosis, 16 for clinicopathological parameters, and 10 for prognosis. For diagnostic value, the pooled sensitivity, pooled specificity, PLR, NLR, DOR, and AUC were 0.82, 0.62, 2.17, 0.29, 7.37, and 0.81, respectively. Upregulation of carcinogenic circRNAs was associated with poor clinical parameters (Gleason score: OR = 0.222, 95% CI: 0.145–0.340; T classification: OR = 0.274, 95% CI: 0.175–0.430; lymph node metastasis: OR = 0.353, 95% CI: 0.175–0.716; tumor size: OR = 0.226, 95% CI: 0.099–0.518) and could predict poor survival outcomes (HR = 2.408, 95% CI: 1.559–3.720, p < 0.001). Conversely, downregulation of tumor-suppressor circRNAs was also associated with poor clinical parameters (Gleason score: OR = 1.689, 95% CI: 1.144–2.493; T classification: OR = 2.586, 95% CI: 1.779–3.762) and worse prognosis (HR = 1.739, 95% CI: 1.147–2.576, p = 0.006).ConclusionOur results showed that circRNAs might be useful biomarkers for the diagnosis and prognosis of PCa.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021284785.https://www.frontiersin.org/articles/10.3389/fonc.2022.945143/fullcircular RNAsprostate cancerdiagnosisprognosisclinicopathological features |
| spellingShingle | Jingling Xie Hui Jiang Yuanqing Zhao Xin rui Jin Baolin Li Zixin Zhu Limei Zhang Jinbo Liu Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis Frontiers in Oncology circular RNAs prostate cancer diagnosis prognosis clinicopathological features |
| title | Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis |
| title_full | Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis |
| title_fullStr | Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis |
| title_short | Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis |
| title_sort | prognostic and diagnostic value of circrna expression in prostate cancer a systematic review and meta analysis |
| topic | circular RNAs prostate cancer diagnosis prognosis clinicopathological features |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.945143/full |
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