Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT
ABSTRACTThe purpose of this study was to develop an effective and non-invasive nomogram for evaluating liver obvious inflammation in untreated HBeAg positive patients with chronic hepatitis B virus (HBV) infection. A nomogram was established on a model cohort of 292 treatment-naïve HBeAg positive pa...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2022.2158710 |
| _version_ | 1797367187731644416 |
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| author | Lu Zhang Liu Yang Yuanjiao Gao Xiaoyue Bi Yanjie Lin Wen Deng Tingting Jiang Yao Lu Hongxiao Hao Gang Wan Wei Yi Yao Xie Minghui Li |
| author_facet | Lu Zhang Liu Yang Yuanjiao Gao Xiaoyue Bi Yanjie Lin Wen Deng Tingting Jiang Yao Lu Hongxiao Hao Gang Wan Wei Yi Yao Xie Minghui Li |
| author_sort | Lu Zhang |
| collection | DOAJ |
| description | ABSTRACTThe purpose of this study was to develop an effective and non-invasive nomogram for evaluating liver obvious inflammation in untreated HBeAg positive patients with chronic hepatitis B virus (HBV) infection. A nomogram was established on a model cohort of 292 treatment-naïve HBeAg positive patients with normal alanine aminotransferase (ALT ≤40 U/L) at Beijing Ditan Hospital from January 2008 to March 2018. Then the nomogram was prospectively validated in a cohort of 88 patients from July 2019 to May 2021. Calibration curves and Concordance index were used to evaluate the accuracy of prediction and identification performance of the model. In untreated HBeAg positive chronic hepatitis B virus infection patients with normal ALT, the formula for predicting liver inflammation was Logit (P) =-0.91-0.41×log10 (qHBeAg)+0.11×AST-0.01×PLT. The nomogram had C-index of 0.751 (95% CI, 0.688–0.815), indicating a good consistency between prediction and real observation on the model cohort. The validation cohort confirmed its good performance. In this study, liver inflammation nomograms based on HBeAg, AST, and PLT were established and verified in treatment-naïve HBeAg positive chronic HBV patients with normal ALT. |
| first_indexed | 2024-03-08T17:13:41Z |
| format | Article |
| id | doaj.art-43b46b56c0744ba18c05f3a0a0f32639 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-03-08T17:13:41Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-43b46b56c0744ba18c05f3a0a0f326392024-01-03T17:26:57ZengTaylor & Francis GroupVirulence2150-55942150-56082023-12-0114110.1080/21505594.2022.2158710Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALTLu Zhang0Liu Yang1Yuanjiao Gao2Xiaoyue Bi3Yanjie Lin4Wen Deng5Tingting Jiang6Yao Lu7Hongxiao Hao8Gang Wan9Wei Yi10Yao Xie11Minghui Li12Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Medical Record Statistics, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaABSTRACTThe purpose of this study was to develop an effective and non-invasive nomogram for evaluating liver obvious inflammation in untreated HBeAg positive patients with chronic hepatitis B virus (HBV) infection. A nomogram was established on a model cohort of 292 treatment-naïve HBeAg positive patients with normal alanine aminotransferase (ALT ≤40 U/L) at Beijing Ditan Hospital from January 2008 to March 2018. Then the nomogram was prospectively validated in a cohort of 88 patients from July 2019 to May 2021. Calibration curves and Concordance index were used to evaluate the accuracy of prediction and identification performance of the model. In untreated HBeAg positive chronic hepatitis B virus infection patients with normal ALT, the formula for predicting liver inflammation was Logit (P) =-0.91-0.41×log10 (qHBeAg)+0.11×AST-0.01×PLT. The nomogram had C-index of 0.751 (95% CI, 0.688–0.815), indicating a good consistency between prediction and real observation on the model cohort. The validation cohort confirmed its good performance. In this study, liver inflammation nomograms based on HBeAg, AST, and PLT were established and verified in treatment-naïve HBeAg positive chronic HBV patients with normal ALT.https://www.tandfonline.com/doi/10.1080/21505594.2022.2158710Aspartate aminotransferaseliver inflammationnomogramPLTHepatitis B e antigen |
| spellingShingle | Lu Zhang Liu Yang Yuanjiao Gao Xiaoyue Bi Yanjie Lin Wen Deng Tingting Jiang Yao Lu Hongxiao Hao Gang Wan Wei Yi Yao Xie Minghui Li Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT Virulence Aspartate aminotransferase liver inflammation nomogram PLT Hepatitis B e antigen |
| title | Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT |
| title_full | Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT |
| title_fullStr | Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT |
| title_full_unstemmed | Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT |
| title_short | Nomogram for evaluating obvious liver inflammation in treatment-naïve HBeAg positive chronic hepatitis B virus infection patients with normal ALT |
| title_sort | nomogram for evaluating obvious liver inflammation in treatment naive hbeag positive chronic hepatitis b virus infection patients with normal alt |
| topic | Aspartate aminotransferase liver inflammation nomogram PLT Hepatitis B e antigen |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2022.2158710 |
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