Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population
ObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral. Medications targeting β-adrenoceptor activity have been widely used in older adults. The aim of this study was to exp...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.999666/full |
| _version_ | 1797979435051253760 |
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| author | Shishuang Cui Shishuang Cui Fang Fang Fang Fang Peijing Cui Peijing Cui Qianwen Jiang Qianwen Jiang Shaoqing Xu Shaoqing Xu Zhihong Xu Zhihong Xu Jia'An Hu Jia'An Hu Feika Li Feika Li |
| author_facet | Shishuang Cui Shishuang Cui Fang Fang Fang Fang Peijing Cui Peijing Cui Qianwen Jiang Qianwen Jiang Shaoqing Xu Shaoqing Xu Zhihong Xu Zhihong Xu Jia'An Hu Jia'An Hu Feika Li Feika Li |
| author_sort | Shishuang Cui |
| collection | DOAJ |
| description | ObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral. Medications targeting β-adrenoceptor activity have been widely used in older adults. The aim of this study was to explore the associations between β-adrenoceptor acting drugs and the risk of dementia in the older population.MethodsThe subjects' information was collected from the electronic medical record (EMR) database. A propensity score matching strategy was conducted to select control participants for users of β2-agonists or β-antagonists. Logistic regression analysis was performed to estimate the risk of dementia with the use of β2-agonists or β-antagonists.ResultsA total of 1,429 participants in the EMR database were included in the study. The use of β2-agonists was strongly associated with a decreased risk of dementia [OR = 0.324, 95% confidence interval (CI): 0.149–0.707, P = 0.005]. This decreased risk showed a statistically significant inverse time-dependent pattern (Ptrend = 0.014). However, the use of non-selective β-antagonists significantly correlated with an increased dementia risk (OR = 1.961, 95% CI: 1.144–3.359, P = 0.014), although no time-dependent manner was found (Ptrend = 0.220). There was no association between selective β1-antagonists usage and dementia risk (OR = 1.114, P = 0.625).ConclusionThe use of β-adrenoceptor acting drugs seems to be associated with the risk of dementia. Pharmacological interventions modulating β2-adrenoceptor activity might be a potential target in therapeutics for dementia. |
| first_indexed | 2024-04-11T05:38:57Z |
| format | Article |
| id | doaj.art-43b4729939ca4b92a4b7b21dde714385 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T05:38:57Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-43b4729939ca4b92a4b7b21dde7143852022-12-22T09:11:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-12-011310.3389/fneur.2022.999666999666Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older populationShishuang Cui0Shishuang Cui1Fang Fang2Fang Fang3Peijing Cui4Peijing Cui5Qianwen Jiang6Qianwen Jiang7Shaoqing Xu8Shaoqing Xu9Zhihong Xu10Zhihong Xu11Jia'An Hu12Jia'An Hu13Feika Li14Feika Li15Department of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Center on Aging, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral. Medications targeting β-adrenoceptor activity have been widely used in older adults. The aim of this study was to explore the associations between β-adrenoceptor acting drugs and the risk of dementia in the older population.MethodsThe subjects' information was collected from the electronic medical record (EMR) database. A propensity score matching strategy was conducted to select control participants for users of β2-agonists or β-antagonists. Logistic regression analysis was performed to estimate the risk of dementia with the use of β2-agonists or β-antagonists.ResultsA total of 1,429 participants in the EMR database were included in the study. The use of β2-agonists was strongly associated with a decreased risk of dementia [OR = 0.324, 95% confidence interval (CI): 0.149–0.707, P = 0.005]. This decreased risk showed a statistically significant inverse time-dependent pattern (Ptrend = 0.014). However, the use of non-selective β-antagonists significantly correlated with an increased dementia risk (OR = 1.961, 95% CI: 1.144–3.359, P = 0.014), although no time-dependent manner was found (Ptrend = 0.220). There was no association between selective β1-antagonists usage and dementia risk (OR = 1.114, P = 0.625).ConclusionThe use of β-adrenoceptor acting drugs seems to be associated with the risk of dementia. Pharmacological interventions modulating β2-adrenoceptor activity might be a potential target in therapeutics for dementia.https://www.frontiersin.org/articles/10.3389/fneur.2022.999666/fullβ-adrenoceptorβ2-agonistsβ-antagonistsdementianoradrenergic |
| spellingShingle | Shishuang Cui Shishuang Cui Fang Fang Fang Fang Peijing Cui Peijing Cui Qianwen Jiang Qianwen Jiang Shaoqing Xu Shaoqing Xu Zhihong Xu Zhihong Xu Jia'An Hu Jia'An Hu Feika Li Feika Li Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population Frontiers in Neurology β-adrenoceptor β2-agonists β-antagonists dementia noradrenergic |
| title | Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population |
| title_full | Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population |
| title_fullStr | Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population |
| title_full_unstemmed | Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population |
| title_short | Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population |
| title_sort | associations between the use of β adrenoceptor acting drugs and the risk of dementia in older population |
| topic | β-adrenoceptor β2-agonists β-antagonists dementia noradrenergic |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.999666/full |
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