The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01774-2 |
| _version_ | 1818749307945222144 |
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| author | Giovanni S. Offeddu Cynthia Hajal Colleen R. Foley Zhengpeng Wan Lina Ibrahim Mark F. Coughlin Roger D. Kamm |
| author_facet | Giovanni S. Offeddu Cynthia Hajal Colleen R. Foley Zhengpeng Wan Lina Ibrahim Mark F. Coughlin Roger D. Kamm |
| author_sort | Giovanni S. Offeddu |
| collection | DOAJ |
| description | Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis. |
| first_indexed | 2024-12-18T04:01:42Z |
| format | Article |
| id | doaj.art-43b59cb8b39a432e9084aba3c7f1be2c |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-18T04:01:42Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-43b59cb8b39a432e9084aba3c7f1be2c2022-12-21T21:21:40ZengNature PortfolioCommunications Biology2399-36422021-02-014111010.1038/s42003-021-01774-2The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic disseminationGiovanni S. Offeddu0Cynthia Hajal1Colleen R. Foley2Zhengpeng Wan3Lina Ibrahim4Mark F. Coughlin5Roger D. Kamm6Department of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Mechanical Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Mechanical Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyOffeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.https://doi.org/10.1038/s42003-021-01774-2 |
| spellingShingle | Giovanni S. Offeddu Cynthia Hajal Colleen R. Foley Zhengpeng Wan Lina Ibrahim Mark F. Coughlin Roger D. Kamm The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination Communications Biology |
| title | The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination |
| title_full | The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination |
| title_fullStr | The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination |
| title_full_unstemmed | The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination |
| title_short | The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination |
| title_sort | cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination |
| url | https://doi.org/10.1038/s42003-021-01774-2 |
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