The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD
Dioxins are chemical compounds that may cause an inflammatory reaction. During dioxin-induced inflammation, generated reactive oxygen species lead to morphological changes in various tissues and in biochemical parameters. The aim of this study was to demonstrate the changes in the livers of rats who...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/11/12/3430 |
| _version_ | 1797506928080846848 |
|---|---|
| author | Maciej Dobrzyński Jan P. Madej Anna Leśków Małgorzata Tarnowska Jacek Majda Monika Szopa Andrzej Gamian Piotr Kuropka |
| author_facet | Maciej Dobrzyński Jan P. Madej Anna Leśków Małgorzata Tarnowska Jacek Majda Monika Szopa Andrzej Gamian Piotr Kuropka |
| author_sort | Maciej Dobrzyński |
| collection | DOAJ |
| description | Dioxins are chemical compounds that may cause an inflammatory reaction. During dioxin-induced inflammation, generated reactive oxygen species lead to morphological changes in various tissues and in biochemical parameters. The aim of this study was to demonstrate the changes in the livers of rats whose mothers were exposed to dioxins and the protective role of α-tocopherol and acetylsalicylic acid in liver inflammation. The study material consisted of Buffalo rats who were the offspring of females treated with dioxin, dioxin + α-tocopherol, or dioxin + acetylsalicylic acid. Livers and blood samples were taken from the rats’ offspring, and then histopathological and biochemical analyses were performed. The histopathological analysis showed that the changes observed in the livers of neonates were the result of the dioxins derived from their mother. The biochemical analysis showed that the morphological changes in the liver affected its function, which manifested in a higher total protein concentration in the dioxin-treated group, and that the creatinine level in this group was significantly higher than that in the other groups. This effect was reduced by the protective role of α-tocopherol and acetylsalicylic acid. Based on these results, we came to the conclusion that dioxins significantly affect the structure of the liver, which negatively affects its function, mainly in the scope of the metabolism of plasma proteins and hepatic enzymes. |
| first_indexed | 2024-03-10T04:39:24Z |
| format | Article |
| id | doaj.art-43b7021162454b60b4b7410106ee0323 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T04:39:24Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-43b7021162454b60b4b7410106ee03232023-11-23T03:26:50ZengMDPI AGAnimals2076-26152021-12-011112343010.3390/ani11123430The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDDMaciej Dobrzyński0Jan P. Madej1Anna Leśków2Małgorzata Tarnowska3Jacek Majda4Monika Szopa5Andrzej Gamian6Piotr Kuropka7Department of Pediatric Dentistry and Preclinical Dentistry, Faculty of Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, PolandDepartment of Histology and Embryology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, PolandDepartment of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, Grunwaldzka 2, 50-368 Wroclaw, PolandDepartment of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, Grunwaldzka 2, 50-368 Wroclaw, PolandDepartment of Laboratory Diagnostics, 4th Military Hospital, Weigla 5, 50-981 Wroclaw, PolandMilitary Center for Preventive Medicine, Slezna 158, 50-984 Wroclaw, PolandHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, PolandDepartment of Histology and Embryology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, PolandDioxins are chemical compounds that may cause an inflammatory reaction. During dioxin-induced inflammation, generated reactive oxygen species lead to morphological changes in various tissues and in biochemical parameters. The aim of this study was to demonstrate the changes in the livers of rats whose mothers were exposed to dioxins and the protective role of α-tocopherol and acetylsalicylic acid in liver inflammation. The study material consisted of Buffalo rats who were the offspring of females treated with dioxin, dioxin + α-tocopherol, or dioxin + acetylsalicylic acid. Livers and blood samples were taken from the rats’ offspring, and then histopathological and biochemical analyses were performed. The histopathological analysis showed that the changes observed in the livers of neonates were the result of the dioxins derived from their mother. The biochemical analysis showed that the morphological changes in the liver affected its function, which manifested in a higher total protein concentration in the dioxin-treated group, and that the creatinine level in this group was significantly higher than that in the other groups. This effect was reduced by the protective role of α-tocopherol and acetylsalicylic acid. Based on these results, we came to the conclusion that dioxins significantly affect the structure of the liver, which negatively affects its function, mainly in the scope of the metabolism of plasma proteins and hepatic enzymes.https://www.mdpi.com/2076-2615/11/12/3430dioxinhistologyinflammationantioxidantadaptation |
| spellingShingle | Maciej Dobrzyński Jan P. Madej Anna Leśków Małgorzata Tarnowska Jacek Majda Monika Szopa Andrzej Gamian Piotr Kuropka The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD Animals dioxin histology inflammation antioxidant adaptation |
| title | The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD |
| title_full | The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD |
| title_fullStr | The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD |
| title_full_unstemmed | The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD |
| title_short | The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD |
| title_sort | improvement of the adaptation process of tocopherol and acetylsalicylic acid in offspring of mothers exposed to tcdd |
| topic | dioxin histology inflammation antioxidant adaptation |
| url | https://www.mdpi.com/2076-2615/11/12/3430 |
| work_keys_str_mv | AT maciejdobrzynski theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT janpmadej theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT annaleskow theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT małgorzatatarnowska theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT jacekmajda theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT monikaszopa theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT andrzejgamian theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT piotrkuropka theimprovementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT maciejdobrzynski improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT janpmadej improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT annaleskow improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT małgorzatatarnowska improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT jacekmajda improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT monikaszopa improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT andrzejgamian improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd AT piotrkuropka improvementoftheadaptationprocessoftocopherolandacetylsalicylicacidinoffspringofmothersexposedtotcdd |