The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies
Despite decades of research, no therapies are available to halt or slow down the course of neuro-degenerative disorders. Most of the drugs developed to fight neurodegeneration are aimed to alleviate symptoms, but none has proven adequate in altering the course of the pathologies. Cell therapy has em...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1686 |
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| author | Niccolò Candelise Francesca Santilli Jessica Fabrizi Daniela Caissutti Zaira Spinello Camilla Moliterni Loreto Lancia Simona Delle Monache Vincenzo Mattei Roberta Misasi |
| author_facet | Niccolò Candelise Francesca Santilli Jessica Fabrizi Daniela Caissutti Zaira Spinello Camilla Moliterni Loreto Lancia Simona Delle Monache Vincenzo Mattei Roberta Misasi |
| author_sort | Niccolò Candelise |
| collection | DOAJ |
| description | Despite decades of research, no therapies are available to halt or slow down the course of neuro-degenerative disorders. Most of the drugs developed to fight neurodegeneration are aimed to alleviate symptoms, but none has proven adequate in altering the course of the pathologies. Cell therapy has emerged as an intriguing alternative to the classical pharmacological approach. Cell therapy consists of the transplantation of stem cells that can be obtained from various embryonal and adult tissues. Whereas the former holds notable ethical issue, adult somatic stem cells can be obtained without major concerns. However, most adult stem cells, such as those derived from the bone marrow, are committed toward the mesodermal lineage, and hence need to be reprogrammed to induce the differentiation into the neurons. The discovery of neural crest stem cells in the dental pulp, both in adults’ molar and in baby teeth (dental pulp stem cells and stem cells from human exfoliated deciduous teeth, respectively) prompted researchers to investigate their utility as therapy in nervous system disorders. In this review, we recapitulate the advancements on the application of these stem cells in preclinical models of neurodegenerative diseases, highlighting differences and analogies in their maintenance, differentiation, and potential clinical application. |
| first_indexed | 2024-03-11T01:45:02Z |
| format | Article |
| id | doaj.art-43b715247621423e972db6f330624770 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:45:02Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-43b715247621423e972db6f3306247702023-11-18T16:18:35ZengMDPI AGCells2073-44092023-06-011213168610.3390/cells12131686The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System PathologiesNiccolò Candelise0Francesca Santilli1Jessica Fabrizi2Daniela Caissutti3Zaira Spinello4Camilla Moliterni5Loreto Lancia6Simona Delle Monache7Vincenzo Mattei8Roberta Misasi9National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, ItalyBiomedicine and Advanced Technologies Rieti Center, Sabina Universitas, 02100 Rieti, ItalyBiomedicine and Advanced Technologies Rieti Center, Sabina Universitas, 02100 Rieti, ItalyDepartment Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs (NESMOS), “Sapienza” University of Rome, 00189 Rome, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyBiomedicine and Advanced Technologies Rieti Center, Sabina Universitas, 02100 Rieti, ItalyDepartment Experimental Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDespite decades of research, no therapies are available to halt or slow down the course of neuro-degenerative disorders. Most of the drugs developed to fight neurodegeneration are aimed to alleviate symptoms, but none has proven adequate in altering the course of the pathologies. Cell therapy has emerged as an intriguing alternative to the classical pharmacological approach. Cell therapy consists of the transplantation of stem cells that can be obtained from various embryonal and adult tissues. Whereas the former holds notable ethical issue, adult somatic stem cells can be obtained without major concerns. However, most adult stem cells, such as those derived from the bone marrow, are committed toward the mesodermal lineage, and hence need to be reprogrammed to induce the differentiation into the neurons. The discovery of neural crest stem cells in the dental pulp, both in adults’ molar and in baby teeth (dental pulp stem cells and stem cells from human exfoliated deciduous teeth, respectively) prompted researchers to investigate their utility as therapy in nervous system disorders. In this review, we recapitulate the advancements on the application of these stem cells in preclinical models of neurodegenerative diseases, highlighting differences and analogies in their maintenance, differentiation, and potential clinical application.https://www.mdpi.com/2073-4409/12/13/1686stem cellsDPSCsdental pulp stem cellsSHEDsstem cells from human exfoliated deciduous teethneurodegenerative diseases |
| spellingShingle | Niccolò Candelise Francesca Santilli Jessica Fabrizi Daniela Caissutti Zaira Spinello Camilla Moliterni Loreto Lancia Simona Delle Monache Vincenzo Mattei Roberta Misasi The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies Cells stem cells DPSCs dental pulp stem cells SHEDs stem cells from human exfoliated deciduous teeth neurodegenerative diseases |
| title | The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies |
| title_full | The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies |
| title_fullStr | The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies |
| title_full_unstemmed | The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies |
| title_short | The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies |
| title_sort | importance of stem cells isolated from human dental pulp and exfoliated deciduous teeth as therapeutic approach in nervous system pathologies |
| topic | stem cells DPSCs dental pulp stem cells SHEDs stem cells from human exfoliated deciduous teeth neurodegenerative diseases |
| url | https://www.mdpi.com/2073-4409/12/13/1686 |
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