Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation

Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation

Targeting autophagy is a promising therapeutic approach in cancer therapy. Here, we screened 30 traditional herbal medicines to identify novel autophagy regulators and found that Platycodon grandiflorus (PG) and platycodin D (PD), a triterpenoid saponin from PG, inhibited autophagy in glioblastoma m...

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Bibliographic Details
Main Authors: Sol Ji Lee, Yu‐Jeong Choi, Hyo In Kim, Hyo Eun Moon, Sun Ha Paek, Tai Young Kim, Seong‐Gyu Ko
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Molecular Oncology
Subjects:
autophagy
cholesterol
GBM
LDLR
lysosome
platycodin D
Online Access:https://doi.org/10.1002/1878-0261.12966

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